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Protein

Pro-cathepsin H

Gene

CTSH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the overall degradation of proteins in lysosomes.

Catalytic activityi

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1411
Active sitei2811
Active sitei3011

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-SSC-2132295 MHC class II antigen presentation
R-SSC-5683826 Surfactant metabolism
R-SSC-6798695 Neutrophil degranulation
SABIO-RKiO46427

Protein family/group databases

MEROPSiC01.040

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-cathepsin H
Cleaved into the following 4 chains:
Gene namesi
Name:CTSH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000002621823 – 97Sequence analysisAdd BLAST75
PeptideiPRO_000002621998 – 105Cathepsin H mini chain8
PropeptideiPRO_0000026220107 – 1159
ChainiPRO_0000026221116 – 335Cathepsin HAdd BLAST220
ChainiPRO_0000026222116 – 292Cathepsin H heavy chainBy similarityAdd BLAST177
ChainiPRO_0000026223293 – 335Cathepsin H light chainBy similarityAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 327
Disulfide bondi138 ↔ 181
Disulfide bondi172 ↔ 214
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 322

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO46427
PeptideAtlasiO46427
PRIDEiO46427

Expressioni

Gene expression databases

BgeeiENSSSCG00000001770
ExpressionAtlasiO46427 baseline and differential
GenevisibleiO46427 SS

Interactioni

Subunit structurei

Composed of cathepsin H and mini chain; disulfide-linked. Cathepsin H may be split into heavy and light chain. All chains are held together by disulfide bonds.

Protein-protein interaction databases

IntActiO46427, 2 interactors
STRINGi9823.ENSSSCP00000001934

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi122 – 125Combined sources4
Helixi141 – 158Combined sources18
Helixi166 – 172Combined sources7
Helixi173 – 176Combined sources4
Helixi180 – 182Combined sources3
Helixi186 – 196Combined sources11
Beta strandi199 – 201Combined sources3
Turni202 – 204Combined sources3
Helixi218 – 220Combined sources3
Beta strandi221 – 223Combined sources3
Beta strandi225 – 230Combined sources6
Helixi236 – 245Combined sources10
Beta strandi249 – 253Combined sources5
Helixi257 – 260Combined sources4
Beta strandi264 – 267Combined sources4
Beta strandi270 – 272Combined sources3
Turni276 – 278Combined sources3
Beta strandi281 – 291Combined sources11
Beta strandi294 – 300Combined sources7
Beta strandi312 – 316Combined sources5
Turni317 – 320Combined sources4
Helixi321 – 323Combined sources3
Beta strandi329 – 333Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NB3X-ray2.80A/B/C/D116-334[»]
P/R/S/T98-105[»]
1NB5X-ray2.40A/B/C/D116-334[»]
P/R/S/T98-105[»]
8PCHX-ray2.10A116-334[»]
P98-105[»]
ProteinModelPortaliO46427
SMRiO46427
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO46427

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiO46427
KOiK01366
OMAiIMGEDTY
OrthoDBiEOG091G0AKT
TreeFamiTF328985

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWAVLSLLCA GAWLLGPPAC GASNLAVSSF EKLHFKSWMV QHQKKYSLEE
60 70 80 90 100
YHHRLQVFVS NWRKINAHNA GNHTFKLGLN QFSDMSFDEI RHKYLWSEPQ
110 120 130 140 150
NCSATKGNYL RGTGPYPPSM DWRKKGNFVS PVKNQGSCGS CWTFSTTGAL
160 170 180 190 200
ESAVAIATGK MLSLAEQQLV DCAQNFNNHG CQGGLPSQAF EYIRYNKGIM
210 220 230 240 250
GEDTYPYKGQ DDHCKFQPDK AIAFVKDVAN ITMNDEEAMV EAVALYNPVS
260 270 280 290 300
FAFEVTNDFL MYRKGIYSST SCHKTPDKVN HAVLAVGYGE ENGIPYWIVK
310 320 330
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV
Length:335
Mass (Da):37,455
Last modified:June 1, 1998 - v1
Checksum:iF728EB45292C3B55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001169 mRNA Translation: AAB93957.1
RefSeqiNP_999094.1, NM_213929.2
UniGeneiSsc.3593

Genome annotation databases

EnsembliENSSSCT00000001983; ENSSSCP00000001934; ENSSSCG00000001770
GeneIDi396969
KEGGissc:396969

Similar proteinsi

Entry informationi

Entry nameiCATH_PIG
AccessioniPrimary (citable) accession number: O46427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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