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Protein

Ferritin light chain

Gene

FTL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronPROSITE-ProRule annotation1
Metal bindingi58IronPROSITE-ProRule annotation1
Metal bindingi61IronPROSITE-ProRule annotation1
Metal bindingi64IronPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.
R-BTA-917937. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin light chain
Short name:
Ferritin L subunit
Gene namesi
Name:FTL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002010582 – 175Ferritin light chainAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO46415.
PeptideAtlasiO46415.
PRIDEiO46415.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013343.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009965.

Structurei

3D structure databases

ProteinModelPortaliO46415.
SMRiO46415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiO46415.
KOiK13625.
OMAiVNLYLRA.
OrthoDBiEOG091G0J20.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQIRQNYS TEVEAAVNRL VNMQLRASYT YLSLGFYFDR DDVALEGVGH
60 70 80 90 100
FFRELAKEKR EGAERLLKLQ NQRGGRALFL DVQKPSQDEW GKTQDAMEAA
110 120 130 140 150
LLVEKNLNQA LLDLHGLASA RGDPHICDFL ENHFLDEEVK LIKKMGDHLT
160 170
NLRRLAGPQA GLGEYLFERL TLKHD
Length:175
Mass (Da):19,988
Last modified:January 23, 2007 - v3
Checksum:i47EFC85BB18DC978
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003094 mRNA. Translation: BAA24819.1.
AY528246 mRNA. Translation: AAS20594.1.
BC103021 mRNA. Translation: AAI03022.1.
RefSeqiNP_777217.1. NM_174792.3.
XP_003583967.2. XM_003583919.4.
XP_003587783.2. XM_003587735.4.
UniGeneiBt.109450.
Bt.87069.

Genome annotation databases

EnsembliENSBTAT00000009965; ENSBTAP00000009965; ENSBTAG00000013343.
GeneIDi286861.
788801.
KEGGibta:286861.
bta:788801.

Similar proteinsi

Entry informationi

Entry nameiFRIL_BOVIN
AccessioniPrimary (citable) accession number: O46415
Secondary accession number(s): Q3ZBZ3, Q53YP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lys-57 is present instead of the conserved Glu which is expected to bind iron.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families