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O46414

- FRIH_BOVIN

UniProt

O46414 - FRIH_BOVIN

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Protein
Ferritin heavy chain
Gene
FTH1, FTH
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Iron 1 By similarity
Metal bindingi63 – 631Iron 1 By similarity
Metal bindingi63 – 631Iron 2 By similarity
Metal bindingi66 – 661Iron 1 By similarity
Metal bindingi108 – 1081Iron 2 By similarity
Metal bindingi142 – 1421Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. immune response Source: UniProtKB
  3. iron ion transport Source: InterPro
  4. negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_204342. Iron uptake and transport.
REACT_209041. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
Short name:
Ferritin H subunit
Cleaved into the following chain:
Gene namesi
Name:FTH1
Synonyms:FTH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ferritin heavy chain
PRO_0000201045Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 181180Ferritin heavy chain, N-terminally processed
PRO_0000424468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei2 – 21N-acetylthreonine; in Ferritin heavy chain, N-terminally processed By similarity
Modified residuei179 – 1791Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO46414.
PRIDEiO46414.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Structurei

3D structure databases

ProteinModelPortaliO46414.
SMRiO46414. Positions 7-177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 160150Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiO46414.
KOiK00522.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46414-1 [UniParc]FASTAAdd to Basket

« Hide

MTTASPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK    50
NFAKYFLHQS HEEREHAERL MKLQNQRGGR IFLQDIKKPD RDDWENGLTA 100
MECALCLERS VNQSLLELHK LATEKNDPHL CDFIETHYLN EQVEAIKELG 150
DHITNLRKMG APGSGMAEYL FDKHTLGHSE S 181
Length:181
Mass (Da):21,052
Last modified:January 23, 2007 - v3
Checksum:i0B46AEC6381CCAE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003093 mRNA. Translation: BAA24818.1.
AY911329 mRNA. Translation: AAW82097.1.
BC105376 mRNA. Translation: AAI05377.1.
RefSeqiNP_776487.1. NM_174062.3.
UniGeneiBt.5321.
Bt.63493.

Genome annotation databases

GeneIDi281173.
KEGGibta:281173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003093 mRNA. Translation: BAA24818.1 .
AY911329 mRNA. Translation: AAW82097.1 .
BC105376 mRNA. Translation: AAI05377.1 .
RefSeqi NP_776487.1. NM_174062.3.
UniGenei Bt.5321.
Bt.63493.

3D structure databases

ProteinModelPortali O46414.
SMRi O46414. Positions 7-177.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi O46414.
PRIDEi O46414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281173.
KEGGi bta:281173.

Organism-specific databases

CTDi 2495.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223383.
HOVERGENi HBG000410.
InParanoidi O46414.
KOi K00522.

Enzyme and pathway databases

Reactomei REACT_204342. Iron uptake and transport.
REACT_209041. Scavenging by Class A Receptors.

Miscellaneous databases

NextBioi 20805233.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of cDNA clones that encode bovine ferritin H and L chains."
    Orino K., Eguchi K., Nakayama T., Yamamoto S., Watanabe K.
    Comp. Biochem. Physiol. 118B:667-673(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiFRIH_BOVIN
AccessioniPrimary (citable) accession number: O46414
Secondary accession number(s): Q56JZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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