Reviewed, UniProtKB/Swiss-Prot O46412 (SODC_CEREL)

Names and origin

Protein names

Recommended name:
    Superoxide dismutase [Cu-Zn]
    EC=1.15.1.1

Gene names

Name:

SOD1

Organism

Cervus elaphus (Red deer)

Taxonomic identifier

9860 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Cervidae › Cervinae › Cervus

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Acetylation Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antioxidant activity Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 152	151	Superoxide dismutase [Cu-Zn]		PRO_0000164055
Sites
	Metal binding	45	1	Copper; catalytic By similarity
	Metal binding	47	1	Copper; catalytic By similarity
	Metal binding	62	1	Copper; catalytic By similarity
	Metal binding	62	1	Zinc; structural By similarity
	Metal binding	70	1	Zinc; structural By similarity
	Metal binding	79	1	Zinc; structural By similarity
	Metal binding	82	1	Zinc; structural By similarity
	Metal binding	119	1	Copper; catalytic By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	69	1	N6-acetyllysine By similarity
	Modified residue	121	1	N6-acetyllysine By similarity
	Disulfide bond	56 ↔ 145		By similarity
Natural variations
	Natural variant	9	1	L → M in European red deer.
	Natural variant	26	1	H → N in European red deer.

Sequences

	Sequence		Length	Mass (Da)
	O46412-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: BAC5F0E9D3EBFFFD	FASTA	152	15,829
	10 20 30 40 50 60 MATKAVCVLK GDGPVQGTIR FEAKGHTVVV TGSITGLTEG DHGFHVHQFG DNTQGCTSAG 70 80 90 100 110 120 PHFNPLSKKH GGPKDEERHV GDLGNVTADK NGVAKVDIVD SLISLSGEHS IIGRTMVVHE 130 140 150 KPDDLGRGGN EESTKTGNAR NRLACGVIGI AQ

References

[1]	"Characterization of the erythrocyte superoxide dismutase allozymes in the deer Cervus elaphus." He K., Wilton S.D., Tate M.L., Murphy M.P. Anim. Genet. 28:299-301(1997) [PubMed: 9345726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: European red deer and North American wapiti.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U93268 mRNA. Translation: AAB88115.1. U93269 mRNA. Translation: AAB88116.1.
3D structure databases
HSSP	HSSP built from PDB template 1CBJ based on UniProtKB P00442.
SMR	O46412. Positions 2-152.
ModBase	Search...
Phylogenomic databases
HOVERGEN	O46412.
Enzyme and pathway databases
BRENDA	1.15.1.1. 289563.
Family and domain databases
InterPro	IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
ProDom	PD000469. SOD_CU_ZN. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_CEREL

Accession

Primary (citable) accession number: O46412
Secondary accession number(s): O46413

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)