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O46390 (PGS1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene names
Name:BGN
OrganismOvis aries (Sheep) [Complete proteome]
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in collagen fiber assembly By similarity.

Subunit structure

Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Found in several connective tissues, especially in articular cartilages.

Post-translational modification

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Contains 12 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainLeucine-rich repeat
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
Proteoglycan
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 3718 By similarity
PRO_0000032699
Chain38 – 369332Biglycan
PRO_0000032700

Regions

Repeat83 – 10321LRR 1
Repeat104 – 12724LRR 2
Repeat128 – 15124LRR 3
Repeat152 – 17221LRR 4
Repeat173 – 19624LRR 5
Repeat197 – 22125LRR 6
Repeat222 – 24221LRR 7
Repeat243 – 26624LRR 8
Repeat267 – 29024LRR 9
Repeat291 – 31323LRR 10
Repeat314 – 34330LRR 11
Repeat344 – 36926LRR 12
Compositional bias64 – 7714Cys-rich

Amino acid modifications

Glycosylation421O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation481O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 70 By similarity
Disulfide bond68 ↔ 77 By similarity
Disulfide bond322 ↔ 355 By similarity

Sequences

Sequence LengthMass (Da)Tools
O46390 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 048C82C233909EE6

FASTA36941,523
        10         20         30         40         50         60 
MCPLWLLAAL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGAETTSGI PDLDSLPPTY 

        70         80         90        100        110        120 
SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL 

       130        140        150        160        170        180 
VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF 

       190        200        210        220        230        240 
SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN 

       250        260        270        280        290        300 
KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 

       310        320        330        340        350        360 
KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL 


AIQFGNYKK 

« Hide

References

[1]Bruett L., Clements J.E.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Choroid plexus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF034842 mRNA. Translation: AAB87988.1.
RefSeqNP_001009201.1. NM_001009201.1.
UniGeneOar.568.

3D structure databases

ProteinModelPortalO46390.
SMRO46390. Positions 62-366.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443011.

Organism-specific databases

CTD633.

Phylogenomic databases

HOVERGENHBG016052.

Family and domain databases

InterProIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFPIRSF002490. SLRP_I. 1 hit.
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGS1_SHEEP
AccessionPrimary (citable) accession number: O46390
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families