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O46390

- PGS1_SHEEP

UniProt

O46390 - PGS1_SHEEP

Protein

Biglycan

Gene

BGN

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    May be involved in collagen fiber assembly.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biglycan
    Alternative name(s):
    Bone/cartilage proteoglycan I
    PG-S1
    Gene namesi
    Name:BGN
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 3718By similarityPRO_0000032699Add
    BLAST
    Chaini38 – 369332BiglycanPRO_0000032700Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan)By similarity
    Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan)By similarity
    Disulfide bondi64 ↔ 70By similarity
    Disulfide bondi68 ↔ 77By similarity
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi322 ↔ 355By similarity

    Post-translational modificationi

    The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Expressioni

    Tissue specificityi

    Found in several connective tissues, especially in articular cartilages.

    Interactioni

    Subunit structurei

    Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO46390.
    SMRiO46390. Positions 62-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati83 – 10321LRR 1Add
    BLAST
    Repeati104 – 12724LRR 2Add
    BLAST
    Repeati128 – 15124LRR 3Add
    BLAST
    Repeati152 – 17221LRR 4Add
    BLAST
    Repeati173 – 19624LRR 5Add
    BLAST
    Repeati197 – 22125LRR 6Add
    BLAST
    Repeati222 – 24221LRR 7Add
    BLAST
    Repeati243 – 26624LRR 8Add
    BLAST
    Repeati267 – 29024LRR 9Add
    BLAST
    Repeati291 – 31323LRR 10Add
    BLAST
    Repeati314 – 34330LRR 11Add
    BLAST
    Repeati344 – 36926LRR 12Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 7714Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 12 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG016052.

    Family and domain databases

    InterProiIPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view]
    PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
    PfamiPF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002490. SLRP_I. 1 hit.
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O46390-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPLWLLAAL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGAETTSGI    50
    PDLDSLPPTY SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN 100
    NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH 150
    LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG 200
    FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL 250
    LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 300
    KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP 350
    ATFRCVTDRL AIQFGNYKK 369
    Length:369
    Mass (Da):41,523
    Last modified:June 1, 1998 - v1
    Checksum:i048C82C233909EE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034842 mRNA. Translation: AAB87988.1.
    RefSeqiNP_001009201.1. NM_001009201.1.
    UniGeneiOar.568.

    Genome annotation databases

    GeneIDi443011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034842 mRNA. Translation: AAB87988.1 .
    RefSeqi NP_001009201.1. NM_001009201.1.
    UniGenei Oar.568.

    3D structure databases

    ProteinModelPortali O46390.
    SMRi O46390. Positions 62-366.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443011.

    Organism-specific databases

    CTDi 633.

    Phylogenomic databases

    HOVERGENi HBG016052.

    Family and domain databases

    InterProi IPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view ]
    PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
    Pfami PF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002490. SLRP_I. 1 hit.
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Bruett L., Clements J.E.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Choroid plexus.

    Entry informationi

    Entry nameiPGS1_SHEEP
    AccessioniPrimary (citable) accession number: O46390
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3