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O46390

- PGS1_SHEEP

UniProt

O46390 - PGS1_SHEEP

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Protein
Biglycan
Gene
BGN
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in collagen fiber assembly By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene namesi
Name:BGN
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 3718 By similarity
PRO_0000032699Add
BLAST
Chaini38 – 369332Biglycan
PRO_0000032700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan) By similarity
Disulfide bondi64 ↔ 70 By similarity
Disulfide bondi68 ↔ 77 By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 355 By similarity

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Interactioni

Subunit structurei

Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.

Structurei

3D structure databases

ProteinModelPortaliO46390.
SMRiO46390. Positions 62-366.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati83 – 10321LRR 1
Add
BLAST
Repeati104 – 12724LRR 2
Add
BLAST
Repeati128 – 15124LRR 3
Add
BLAST
Repeati152 – 17221LRR 4
Add
BLAST
Repeati173 – 19624LRR 5
Add
BLAST
Repeati197 – 22125LRR 6
Add
BLAST
Repeati222 – 24221LRR 7
Add
BLAST
Repeati243 – 26624LRR 8
Add
BLAST
Repeati267 – 29024LRR 9
Add
BLAST
Repeati291 – 31323LRR 10
Add
BLAST
Repeati314 – 34330LRR 11
Add
BLAST
Repeati344 – 36926LRR 12
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 7714Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG016052.

Family and domain databases

InterProiIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46390-1 [UniParc]FASTAAdd to Basket

« Hide

MCPLWLLAAL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGAETTSGI    50
PDLDSLPPTY SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN 100
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH 150
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG 200
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL 250
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 300
KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP 350
ATFRCVTDRL AIQFGNYKK 369
Length:369
Mass (Da):41,523
Last modified:June 1, 1998 - v1
Checksum:i048C82C233909EE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034842 mRNA. Translation: AAB87988.1.
RefSeqiNP_001009201.1. NM_001009201.1.
UniGeneiOar.568.

Genome annotation databases

GeneIDi443011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034842 mRNA. Translation: AAB87988.1 .
RefSeqi NP_001009201.1. NM_001009201.1.
UniGenei Oar.568.

3D structure databases

ProteinModelPortali O46390.
SMRi O46390. Positions 62-366.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443011.

Organism-specific databases

CTDi 633.

Phylogenomic databases

HOVERGENi HBG016052.

Family and domain databases

InterProi IPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view ]
PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF002490. SLRP_I. 1 hit.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Bruett L., Clements J.E.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Choroid plexus.

Entry informationi

Entry nameiPGS1_SHEEP
AccessioniPrimary (citable) accession number: O46390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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