O46390 (PGS1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biglycan

Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1

Gene names

Name:

BGN

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in collagen fiber assembly By similarity.
Subunit structure	Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Found in several connective tissues, especially in articular cartilages.
Post-translational modification	The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.
Sequence similarities	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Contains 12 LRR (leucine-rich) repeats.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Leucine-rich repeat Repeat Signal
PTM	Disulfide bond Glycoprotein Proteoglycan
Gene Ontology (GO)
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 37	18	By similarity		PRO_0000032699
	Chain	38 – 369	332	Biglycan		PRO_0000032700
Regions
	Repeat	83 – 103	21	LRR 1
	Repeat	104 – 127	24	LRR 2
	Repeat	128 – 151	24	LRR 3
	Repeat	152 – 172	21	LRR 4
	Repeat	173 – 196	24	LRR 5
	Repeat	197 – 221	25	LRR 6
	Repeat	222 – 242	21	LRR 7
	Repeat	243 – 266	24	LRR 8
	Repeat	267 – 290	24	LRR 9
	Repeat	291 – 313	23	LRR 10
	Repeat	314 – 343	30	LRR 11
	Repeat	344 – 369	26	LRR 12
	Compositional bias	64 – 77	14	Cys-rich
Amino acid modifications
	Glycosylation	42	1	O-linked (Xyl...) (glycosaminoglycan) By similarity
	Glycosylation	48	1	O-linked (Xyl...) (glycosaminoglycan) By similarity
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Disulfide bond	64 ↔ 70		By similarity
	Disulfide bond	68 ↔ 77		By similarity
	Disulfide bond	322 ↔ 355		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O46390 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 048C82C233909EE6	FASTA	369	41,523
	10 20 30 40 50 60 MCPLWLLAAL LALSQALPFE QKAFWDFTLD DGLPMLNDEE ASGAETTSGI PDLDSLPPTY 70 80 90 100 110 120 SAMCPFGCHC HLRVVQCSDL GLKAVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL 130 140 150 160 170 180 VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF 190 200 210 220 230 240 SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN 250 260 270 280 290 300 KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 310 320 330 340 350 360 KLLQVVYLHT NNITKVGVND FCPVGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL AIQFGNYKK

References

[1]	Bruett L., Clements J.E. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Choroid plexus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF034842 mRNA. Translation: AAB87988.1.
RefSeq	NP_001009201.1. NM_001009201.1.
UniGene	Oar.568.
3D structure databases
ProteinModelPortal	O46390.
SMR	O46390. Positions 62-366.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	443011.
Organism-specific databases
CTD	633.
Phylogenomic databases
HOVERGEN	HBG016052.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR000372. LRR-contain_N. IPR016352. SLRP_I_decor/aspor/byglycan. [Graphical view]
Pfam	PF01462. LRRNT. 1 hit. [Graphical view]
PIRSF	PIRSF002490. SLRP_I. 1 hit.
SMART	SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 8 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGS1_SHEEP

Accession

Primary (citable) accession number: O46390

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	March 21, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program