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Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
30 kDa calsequestrin-binding protein
Short name:
30 kDa CSQ-binding protein
ADP,ATP carrier protein 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:SLC25A4
Synonyms:ANT1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componentsi: Chromosome 13, Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000905762 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PRIDEiO46373

Expressioni

Gene expression databases

BgeeiENSOCUG00000002594

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022784

Structurei

3D structure databases

ProteinModelPortaliO46373
SMRiO46373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiO46373
KOiK05863
OMAiECFKRTA
OrthoDBiEOG091G0ULB
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.101 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQALSFLK DFLAGGVAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFSGLGNC LTKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWKK IAKDEGAKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV
Length:298
Mass (Da):32,901
Last modified:January 23, 2007 - v3
Checksum:iCAEA32C88164AD78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009386 mRNA Translation: BAA23777.1
RefSeqiNP_001076155.1, NM_001082686.1
XP_002715967.1, XM_002715921.3
UniGeneiOcu.6278

Genome annotation databases

EnsembliENSOCUT00000002593; ENSOCUP00000002239; ENSOCUG00000002594
ENSOCUT00000014987; ENSOCUP00000022784; ENSOCUG00000024057
GeneIDi100009414
100349768
KEGGiocu:100009414
ocu:100349768

Similar proteinsi

Entry informationi

Entry nameiADT1_RABIT
AccessioniPrimary (citable) accession number: O46373
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome