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Protein

Calcium-activated potassium channel subunit beta-1

Gene

KCNMB1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-1
Alternative name(s):
BK channel subunit beta-1
Short name:
BKbeta
Short name:
BKbeta1
Calcium-activated potassium channel, subfamily M subunit beta-1
Short name:
Calcium-activated potassium channel subunit beta
Charybdotoxin receptor subunit beta-1
K(VCA)beta-1
Maxi K channel subunit beta-1
Slo-beta-1
Short name:
Slo-beta
Gene namesi
Name:KCNMB1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 157ExtracellularSequence analysisAdd BLAST121
Transmembranei158 – 178Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini179 – 191CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870481 – 191Calcium-activated potassium channel subunit beta-1Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiENSOCUG00000000539.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000466.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWME. Eukaryota.
ENOG41116AX. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000290180.
HOVERGENiHBG052223.
InParanoidiO46372.
KOiK04937.
OMAiMLYHTED.
OrthoDBiEOG091G0MVO.
TreeFamiTF328589.

Family and domain databases

InterProiView protein in InterPro
IPR003930. K_chnl_Ca-activ_BK_bsu.
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiView protein in Pfam
PF03185. CaKB. 1 hit.
PRINTSiPR01450. BKCHANNELB.

Sequencei

Sequence statusi: Complete.

O46372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKLVMAQK RGETRALCLG VAMVMCAVIT YYILGTTMLP LYQKSVWTQE
60 70 80 90 100
SLCRLIETNI RDQEELEGKK VPQYPCLWVN VSAVGKWAVL YHTEETRDRN
110 120 130 140 150
QQCSYIPGSL DNYQMALADV EKVRAKFHER QVFYCFSTTQ ENETSVLYQR
160 170 180 190
LYGPQALLAS LFWPTFLLTG GLLIIAMVKI NRSLSILAAQ K
Length:191
Mass (Da):21,829
Last modified:January 23, 2007 - v3
Checksum:i51EA2FEF9E3C9474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107300 mRNA. Translation: AAD17994.1.
AB001934 mRNA. Translation: BAA25630.1.
AB009313 mRNA. Translation: BAA23748.1.
AY829265 mRNA. Translation: AAV88620.1.
DQ821756 mRNA. Translation: ABG49461.1.
DQ839485 Genomic DNA. Translation: ABG74946.1.
RefSeqiNP_001075694.1. NM_001082225.1.
UniGeneiOcu.2188.

Genome annotation databases

EnsembliENSOCUT00000000539; ENSOCUP00000000466; ENSOCUG00000000539.
GeneIDi100009034.
KEGGiocu:100009034.

Similar proteinsi

Entry informationi

Entry nameiKCMB1_RABIT
AccessioniPrimary (citable) accession number: O46372
Secondary accession number(s): Q5MGS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families