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Protein

Calcium-activated potassium channel subunit beta-1

Gene

KCNMB1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-1
Alternative name(s):
BK channel subunit beta-1
Short name:
BKbeta
Short name:
BKbeta1
Calcium-activated potassium channel, subfamily M subunit beta-1
Short name:
Calcium-activated potassium channel subunit beta
Charybdotoxin receptor subunit beta-1
K(VCA)beta-1
Maxi K channel subunit beta-1
Slo-beta-1
Short name:
Slo-beta
Gene namesi
Name:KCNMB1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 15CytoplasmicSequence analysisAdd BLAST14
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 157ExtracellularSequence analysisAdd BLAST121
Transmembranei158 – 178Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini179 – 191CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001870482 – 191Calcium-activated potassium channel subunit beta-1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000466.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWME. Eukaryota.
ENOG41116AX. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000290180.
HOVERGENiHBG052223.
InParanoidiO46372.
KOiK04937.
OMAiAMLYHTE.
OrthoDBiEOG091G0MVO.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKLVMAQK RGETRALCLG VAMVMCAVIT YYILGTTMLP LYQKSVWTQE
60 70 80 90 100
SLCRLIETNI RDQEELEGKK VPQYPCLWVN VSAVGKWAVL YHTEETRDRN
110 120 130 140 150
QQCSYIPGSL DNYQMALADV EKVRAKFHER QVFYCFSTTQ ENETSVLYQR
160 170 180 190
LYGPQALLAS LFWPTFLLTG GLLIIAMVKI NRSLSILAAQ K
Length:191
Mass (Da):21,829
Last modified:January 23, 2007 - v3
Checksum:i51EA2FEF9E3C9474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107300 mRNA. Translation: AAD17994.1.
AB001934 mRNA. Translation: BAA25630.1.
AB009313 mRNA. Translation: BAA23748.1.
AY829265 mRNA. Translation: AAV88620.1.
DQ821756 mRNA. Translation: ABG49461.1.
DQ839485 Genomic DNA. Translation: ABG74946.1.
RefSeqiNP_001075694.1. NM_001082225.1.
UniGeneiOcu.2188.

Genome annotation databases

EnsembliENSOCUT00000000539; ENSOCUP00000000466; ENSOCUG00000000539.
GeneIDi100009034.
KEGGiocu:100009034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107300 mRNA. Translation: AAD17994.1.
AB001934 mRNA. Translation: BAA25630.1.
AB009313 mRNA. Translation: BAA23748.1.
AY829265 mRNA. Translation: AAV88620.1.
DQ821756 mRNA. Translation: ABG49461.1.
DQ839485 Genomic DNA. Translation: ABG74946.1.
RefSeqiNP_001075694.1. NM_001082225.1.
UniGeneiOcu.2188.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000000466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000000539; ENSOCUP00000000466; ENSOCUG00000000539.
GeneIDi100009034.
KEGGiocu:100009034.

Organism-specific databases

CTDi3779.

Phylogenomic databases

eggNOGiENOG410IWME. Eukaryota.
ENOG41116AX. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000290180.
HOVERGENiHBG052223.
InParanoidiO46372.
KOiK04937.
OMAiAMLYHTE.
OrthoDBiEOG091G0MVO.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.
ProtoNetiSearch...

Entry informationi

Entry nameiKCMB1_RABIT
AccessioniPrimary (citable) accession number: O46372
Secondary accession number(s): Q5MGS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.