O46345 (O46345_LOLPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: S-syntaxin EMBL CAA74913.1 Submitted name: Syntaxin EMBL BAA24019.1
Organism	Loligo pealeii (Longfin inshore squid) (Loligo pallida) EMBL CAA74913.1
Taxonomic identifier	1051067 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Decapodiformes › Teuthida › Myopsina › Loliginidae › Doryteuthis

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the syntaxin family. RuleBase RU003858 Contains 1 t-SNARE coiled-coil homology domain. SAAS SAAS000727

Ontologies

Keywords
Domain	Coiled coil SAAS SAAS000727
Technical term	3D-structure PDB 1S94 PDB 1L4A
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	SNAP receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O46345 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: BF8B2186D36FE9C8	FASTA	292	33,142
	10 20 30 40 50 60 MTKDRLAALK AAVSDEEDVE EVAVQVDSGG GFMEEFFEQV EEIRAMIDKI SDNVDAVKKK 70 80 90 100 110 120 HSDILSAPQT DDQMKEELEE LMTDIKRTAN KVRGKLKTIE LNIEQEEHSN KSSADLRIRK 130 140 150 160 170 180 TQYSTISRKF VEVMSDYNTT QIDYRDRCKA RIKRQMEITG RTTTNEELED MLESGNPAIF 190 200 210 220 230 240 TQGIIMETQQ AKQTLADIEA RHADIMKLET SIRELHDMFM DMAMLVESQG EMIDRIEYNV 250 260 270 280 290 EAAVDYIETA KVDTKKAVKY QSKARQKKIA ILVCLVILVL VIVSTVGGVF GG

References

[1]	"Presynaptic injection of syntaxin-specific antibodies blocks transmission in the squid giant synapse." Sugimori M., Tong C.-T., Fukuda M., Moreira J.E., Kojima T., Mikoshiba K., Llinas R. Neuroscience 86:39-51(1998) [PubMed: 9692742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Optic lobe EMBL BAA24019.1.
[2]	"Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei reveals conformational plasticity at its C-terminus." Bracher A., Weissenhorn W. BMC Struct. Biol. 4:6-6(2004) [PubMed: 15113421] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.34 ANGSTROMS) OF 2-175.
[3]	"Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion." O'Connor V., Heuss C., De Bello W.M., Dresbach T., Charlton M.P., Hunt J.H., Pellegrini L.L., Hodel A., Burger M.M., Betz H., Augustine G.J., Schafer T. Proc. Natl. Acad. Sci. U.S.A. 94:12186-12191(1997) [PubMed: 9342384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"X-ray structure of a neuronal complexin-SNARE complex from squid." Bracher A., Kadlec J., Betz H., Weissenhorn W. J. Biol. Chem. 277:26517-26523(2002) [PubMed: 12004067] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 183-265.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D78271 mRNA. Translation: BAA24019.1.
Y14575 mRNA. Translation: CAA74913.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1L4A	X-ray	2.95	B	183-265	[»]
1S94	X-ray	3.34	A/B	2-175	[»]

ProteinModelPortal

O46345.

SMR

O46345. Positions 32-259.

ModBase

Search...

Protein-protein interaction databases

IntAct

O46345. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]

Pfam

PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]

SMART

SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]

SUPFAM

SSF47661. t-snare. 1 hit.

PROSITE

PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O46345_LOLPE

Accession

Primary (citable) accession number: O46345

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	October 19, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)