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Protein
Submitted name:

Amiloride-sensitive Na+ channel

Gene

rpk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of pain Source: FlyBase
  • sensory perception of touch Source: FlyBase
  • sodium ion transport Source: FlyBase

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationSAAS annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

TCDBi1.A.6.4.1 the epithelial na(+) channel (enac) family

Names & Taxonomyi

Protein namesi
Submitted name:
Amiloride-sensitive Na+ channelImported
Submitted name:
Gonad-specific amiloride-sensitive sodium channel 1Imported
Submitted name:
Ripped pocket, isoform AImported
Gene namesi
Name:rpkImported
Synonyms:dGNaC1Imported, Dmel\CG1058Imported, GNaC1Imported, ppk2Imported, RPKImported
ORF Names:CG1058Imported, Dmel_CG1058Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0022981 rpk

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 83HelicalSequence analysisAdd BLAST22
Transmembranei522 – 548HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiO46342

Expressioni

Gene expression databases

BgeeiFBgn0022981
ExpressionAtlasiO46342 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiO46342, 1 interactor

Structurei

3D structure databases

SMRiO46342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4294 Eukaryota
ENOG410ZNFK LUCA
OMAiHTPWTLE
OrthoDBiEOG091G0IBX

Family and domain databases

InterProiView protein in InterPro
IPR001873 ENaC
IPR020903 ENaC_CS
PANTHERiPTHR11690 PTHR11690, 1 hit
PfamiView protein in Pfam
PF00858 ASC, 1 hit
PRINTSiPR01078 AMINACHANNEL
PROSITEiView protein in PROSITE
PS01206 ASC, 1 hit

Sequencei

Sequence statusi: Complete.

O46342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISDSELDS SKGIDLTFRR RRKAGSVACE GFITTYHEYC RNTSIHGVQY
60 70 80 90 100
LGEQERPFRE RIFWLFVFLI SIYGCSTLIQ SAYTKWTETP VIVSFAEKST
110 120 130 140 150
PVWNIPFPAV TVCSETKRVL KQKGKETTYA DLYSQFSEDM RASRVFRPEN
160 170 180 190 200
VSALEMEEFR TLLHVCNTQI IEEDIPLIAG DDLDYFDVLQ RMLPQFDRYF
210 220 230 240 250
FYCRWLSRFG ECETFFRKTL TEEGICYTFN GLRATEIYRD DTYQYQHSGE
260 270 280 290 300
PLEMENISSQ HTAWTLETGY ALDSDVETFP ARVLSAGARS GIFLALQSFK
310 320 330 340 350
QEVDYACRGP VQGFKVLLHA PDDVPQVSKQ FVRIPMGKEV LIAVKPNMIT
360 370 380 390 400
MSSGIAEYHP VRRQCFLSHE RSLRFFKVYT ESNCQLECLA NFTLTKCGCV
410 420 430 440 450
KFSMPRNVDM PVCGEDKIHC YDRAERELLV REFKRVKALN AGRENSRSVE
460 470 480 490 500
SACNCMPACT SLVYNTEISQ ANFDLEEMLV AEGDTEFLKE YPGSQMSRLS
510 520 530 540 550
IYFKQSQFIT SKRSELYGMT EFLANCGGIF GLFMGFSILS LVEMIYHFTL
560
RLFTNLKRLV KG
Length:562
Mass (Da):64,768
Last modified:June 1, 1998 - v1
Checksum:iE67793B6E677EF0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043264 mRNA Translation: AAC38824.1
AE014297 Genomic DNA Translation: AAF52108.2
Y16240 mRNA Translation: CAA76129.1
RefSeqiNP_524225.1, NM_079501.4
UniGeneiDm.2158

Genome annotation databases

EnsemblMetazoaiFBtr0078859; FBpp0078499; FBgn0022981
GeneIDi40580
UCSCiCG1058-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiO46342_DROME
AccessioniPrimary (citable) accession number: O46342
Secondary accession number(s): Q9VN43
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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