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Protein
Submitted name:

Amiloride-sensitive Na+ channel

Gene

rpk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of pain Source: FlyBase
  • sensory perception of pain Source: FlyBase
  • sensory perception of touch Source: FlyBase
  • sodium ion transport Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi1.A.6.4.1. the epithelial na(+) channel (enac) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Amiloride-sensitive Na+ channelImported
Submitted name:
Gonad-specific amiloride-sensitive sodium channel 1Imported
Submitted name:
Ripped pocket, isoform AImported
Gene namesi
Name:rpkImported
Synonyms:dGNaC1Imported
ORF Names:CG1058Imported, Dmel_CG1058Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0022981. rpk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 8322HelicalSequence analysisAdd
BLAST
Transmembranei522 – 54827HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: FlyBase
  • dendrite Source: FlyBase
  • integral component of membrane Source: FlyBase
  • neuronal cell body Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0293856.

Family & Domainsi

Sequence similaritiesi

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00540000071900.
OrthoDBiEOG7DFXBQ.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 2 hits.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISDSELDS SKGIDLTFRR RRKAGSVACE GFITTYHEYC RNTSIHGVQY
60 70 80 90 100
LGEQERPFRE RIFWLFVFLI SIYGCSTLIQ SAYTKWTETP VIVSFAEKST
110 120 130 140 150
PVWNIPFPAV TVCSETKRVL KQKGKETTYA DLYSQFSEDM RASRVFRPEN
160 170 180 190 200
VSALEMEEFR TLLHVCNTQI IEEDIPLIAG DDLDYFDVLQ RMLPQFDRYF
210 220 230 240 250
FYCRWLSRFG ECETFFRKTL TEEGICYTFN GLRATEIYRD DTYQYQHSGE
260 270 280 290 300
PLEMENISSQ HTAWTLETGY ALDSDVETFP ARVLSAGARS GIFLALQSFK
310 320 330 340 350
QEVDYACRGP VQGFKVLLHA PDDVPQVSKQ FVRIPMGKEV LIAVKPNMIT
360 370 380 390 400
MSSGIAEYHP VRRQCFLSHE RSLRFFKVYT ESNCQLECLA NFTLTKCGCV
410 420 430 440 450
KFSMPRNVDM PVCGEDKIHC YDRAERELLV REFKRVKALN AGRENSRSVE
460 470 480 490 500
SACNCMPACT SLVYNTEISQ ANFDLEEMLV AEGDTEFLKE YPGSQMSRLS
510 520 530 540 550
IYFKQSQFIT SKRSELYGMT EFLANCGGIF GLFMGFSILS LVEMIYHFTL
560
RLFTNLKRLV KG
Length:562
Mass (Da):64,768
Last modified:June 1, 1998 - v1
Checksum:iE67793B6E677EF0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043264 mRNA. Translation: AAC38824.1.
AE014297 Genomic DNA. Translation: AAF52108.2.
Y16240 mRNA. Translation: CAA76129.1.
RefSeqiNP_524225.1. NM_079501.4.
UniGeneiDm.2158.

Genome annotation databases

EnsemblMetazoaiFBtr0078859; FBpp0078499; FBgn0022981.
GeneIDi40580.
UCSCiCG1058-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043264 mRNA. Translation: AAC38824.1.
AE014297 Genomic DNA. Translation: AAF52108.2.
Y16240 mRNA. Translation: CAA76129.1.
RefSeqiNP_524225.1. NM_079501.4.
UniGeneiDm.2158.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0293856.

Protein family/group databases

TCDBi1.A.6.4.1. the epithelial na(+) channel (enac) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078859; FBpp0078499; FBgn0022981.
GeneIDi40580.
UCSCiCG1058-RA. d. melanogaster.

Organism-specific databases

CTDi40580.
FlyBaseiFBgn0022981. rpk.

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
GeneTreeiENSGT00540000071900.
OrthoDBiEOG7DFXBQ.

Miscellaneous databases

GenomeRNAii40580.

Family and domain databases

InterProiIPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 2 hits.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system."
    Darboux I., Lingueglia E., Pauron D., Barbry P., Lazdunski M.
    Biochem. Biophys. Res. Commun. 246:210-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Whole flyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Whole flyImported.
  3. "Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons."
    Adams C.M., Anderson M.G., Motto D.G., Price M.P., Johnson W.A., Welsh M.J.
    J. Cell Biol. 140:143-152(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton SImported.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  14. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO46342_DROME
AccessioniPrimary (citable) accession number: O46342
Secondary accession number(s): Q9VN43
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.