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O46310 (RIR2_LEIAM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small subunit

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase M2 subunit
Ribonucleotide reductase small subunit
OrganismLeishmania amazonensis
Taxonomic identifier5659 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Ribonucleoside-diphosphate reductase small subunit
PRO_0000190457

Sites

Active site1311 By similarity
Metal binding931Iron 1 By similarity
Metal binding1241Iron 1 By similarity
Metal binding1241Iron 2 By similarity
Metal binding1271Iron 1 By similarity
Metal binding1861Iron 2 By similarity
Metal binding2201Iron 2 By similarity
Metal binding2231Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O46310 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D0829B1BFE9EA115

FASTA34539,651
        10         20         30         40         50         60 
MKPVAAGAEV LPADKVAQGT NAEEEPLQQE NPFRYVLFPI QYHDIWRKYK EQESCIWTVE 

        70         80         90        100        110        120 
EIDLGNDMKD WATLNDGERH FIKHVLAFFA GSDGIVIENL AQRFMSDVKV PEARAFYGFQ 

       130        140        150        160        170        180 
LMMENIHSET YSVLLDTYIT DSEEKLRLLH AIQTIPCIQK KAEWPVRWIG SSASFQQRLI 

       190        200        210        220        230        240 
GFAAVEGIFF SGSFCALFWL KKRGLMPGLT FSNELISRDE GLHTDFACLL YNSHIKHKLP 

       250        260        270        280        290        300 
RERVLEIIVD AVNIEREFIC DALPVRLIGM NAELMAQYIE FVADRLLVSL GEEKHYRSTQ 

       310        320        330        340 
PFDFMEMISL QGKTNFFEKR VGEYQKAGVM STEGTSKKFS LSEDF 

« Hide

References

[1]"Cloning and functional analysis of the ribonucleotide reductase gene small subunit from hydroxyurea-resistant Leishmania mexicana amazonensis."
Lye L.-F., Hsieh Y.-H., Su K.-E., Lee S.T.
Mol. Biochem. Parasitol. 90:353-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF005247 Genomic DNA. Translation: AAC08302.1.

3D structure databases

ProteinModelPortalO46310.
SMRO46310. Positions 21-306.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_LEIAM
AccessionPrimary (citable) accession number: O46310
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways