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O46310

- RIR2_LEIAM

UniProt

O46310 - RIR2_LEIAM

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Protein

Ribonucleoside-diphosphate reductase small subunit

Gene
N/A
Organism
Leishmania amazonensis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Iron 1 By similarity
Metal bindingi124 – 1241Iron 1 By similarity
Metal bindingi124 – 1241Iron 2 By similarity
Metal bindingi127 – 1271Iron 1 By similarity
Active sitei131 – 1311 By similarity
Metal bindingi186 – 1861Iron 2 By similarity
Metal bindingi220 – 2201Iron 2 By similarity
Metal bindingi223 – 2231Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small subunit (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase M2 subunit
Ribonucleotide reductase small subunit
OrganismiLeishmania amazonensis
Taxonomic identifieri5659 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Ribonucleoside-diphosphate reductase small subunitPRO_0000190457Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliO46310.
SMRiO46310. Positions 21-306.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46310-1 [UniParc]FASTAAdd to Basket

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MKPVAAGAEV LPADKVAQGT NAEEEPLQQE NPFRYVLFPI QYHDIWRKYK    50
EQESCIWTVE EIDLGNDMKD WATLNDGERH FIKHVLAFFA GSDGIVIENL 100
AQRFMSDVKV PEARAFYGFQ LMMENIHSET YSVLLDTYIT DSEEKLRLLH 150
AIQTIPCIQK KAEWPVRWIG SSASFQQRLI GFAAVEGIFF SGSFCALFWL 200
KKRGLMPGLT FSNELISRDE GLHTDFACLL YNSHIKHKLP RERVLEIIVD 250
AVNIEREFIC DALPVRLIGM NAELMAQYIE FVADRLLVSL GEEKHYRSTQ 300
PFDFMEMISL QGKTNFFEKR VGEYQKAGVM STEGTSKKFS LSEDF 345
Length:345
Mass (Da):39,651
Last modified:June 1, 1998 - v1
Checksum:iD0829B1BFE9EA115
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005247 Genomic DNA. Translation: AAC08302.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005247 Genomic DNA. Translation: AAC08302.1 .

3D structure databases

ProteinModelPortali O46310.
SMRi O46310. Positions 21-306.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional analysis of the ribonucleotide reductase gene small subunit from hydroxyurea-resistant Leishmania mexicana amazonensis."
    Lye L.-F., Hsieh Y.-H., Su K.-E., Lee S.T.
    Mol. Biochem. Parasitol. 90:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiRIR2_LEIAM
AccessioniPrimary (citable) accession number: O46310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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