O46205 (O46205_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Zinc-finger nuclear protein hindsight EMBL AAB95640.1

Gene names

Name:	peb FlyBase FBgn0003053
Synonyms:	hindsight EMBL AAB95640.1
ORF Names:	CG12212 FlyBase FBgn0003053

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1920 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Nucleus EMBL AAB95640.1
Domain	Zinc-finger EMBL AAB95640.1
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	amnioserosa maintenance Inferred from mutant phenotype PubMed 8625823. Source: FlyBase dorsal closure, leading edge cell fate determination Non-traceable author statement PubMed 11532914. Source: FlyBase ectoderm development Traceable author statement PubMed 14642751. Source: FlyBase germ-band shortening Inferred from mutant phenotype PubMed 8946251PubMed 10491260PubMed 8625823. Source: FlyBase head involution Non-traceable author statement PubMed 8625823. Source: FlyBase maintenance of epithelial integrity, open tracheal system Inferred from mutant phenotype PubMed 10694415. Source: FlyBase negative regulation of JNK cascade Inferred from genetic interaction PubMed 11509232. Source: FlyBase ommatidial rotation Inferred from mutant phenotype PubMed 11959832. Source: FlyBase photoreceptor cell morphogenesis Inferred from mutant phenotype PubMed 11959832. Source: FlyBase regulation of transcription, DNA-dependent Non-traceable author statement PubMed 12231351. Source: FlyBase terminal region determination Inferred from genetic interaction PubMed 1905816. Source: FlyBase torso signaling pathway Inferred from genetic interaction PubMed 1905816. Source: FlyBase wing disc dorsal/ventral pattern formation Inferred from genetic interaction PubMed 15647319. Source: FlyBase
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O46205 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: BA51E67584916AA2	FASTA	1,920	208,975
	10 20 30 40 50 60 MLAAQQQHNN STVVLEMERQ RRDSTTSESS LEHLDLGRTP KKLGGNSGST QTTSTPHELA 70 80 90 100 110 120 TVTSSRKRKI RHLQLNHHQQ QQHHQQSDLL SDEDVVEAEA EEDEDDEDGD QVAALGSRNL 130 140 150 160 170 180 GRHKQRRSGG ATTQASIVMD YSSGDASSLR KKFRLNRSAA SLSESGFVDA SSTTGHSGYL 190 200 210 220 230 240 GNSSSATNTT ATSGIGASAV APSPVGGAAI NAASSSSGSS SGGSGGSSPQ GQCLSSGESG 250 260 270 280 290 300 IGAGDEHMKY LCPICEVVSA TPHEFTNHIR CHNYANGDTE NFTCRICSKV LSSASSLDRH 310 320 330 340 350 360 VLVHTGERPF NCRYCHLTFT TNGNMHRHMR THKQHQVAQS QSQSQQQQSL QQQQQSQQQR 370 380 390 400 410 420 RQQQQHQPSQ QQQNPAQQQL MGNTLSAGAE SYESDASCST DVSSGHSHSR SSSSLNNNNN 430 440 450 460 470 480 NSHKANNNLK DLEELEVSTE DQDTENKQRR LKTTINNNII ESEQQEDMDD EEADDADVAM 490 500 510 520 530 540 LTSTPDVATL LAGASASGAA SRSPTPSPSA SPALLLSCPA CGASDFETLP ALCVHLDAMH 550 560 570 580 590 600 SDIPAKCRDC EVIFATHRQL QSHCCRLPNA LAGGLPPLLG ASSSPLHNEE PEDEEHGDDE 610 620 630 640 650 660 DLEQKERLAS QSEDFFHQLY LKHKTANGCG AISHPPSPIK HEPADTKDLA DIQSILNMTS 670 680 690 700 710 720 SSSSFLRNFE QSVNTPNSSQ YSLDGRDQEE EAQDAFTSEF RRMKLRGEFP CKLCTAVFPN 730 740 750 760 770 780 LRALKGHNRV HLGAVGPAGP FRCNMCPYAV CDKAALVRHM RTHNGDRPYE CAVCNYAFTT 790 800 810 820 830 840 KANCERHLRN RHGKTSREEV KRAIVYHPAE DAGCEDSKSR LGEDLADTSF RSISPTPPPP 850 860 870 880 890 900 PVNESKSQLK HMLLGENHLA PVNQQPPLKI QVKSLDQLVD KKPSAPAPQQ QQQQQQQEKS 910 920 930 940 950 960 GSALDFSMDV LDLSKKPTGG ASLTPAVTRT PTPAAVAPVT PGGVGTPDLA AAIEQQQLLL 970 980 990 1000 1010 1020 AQQQLFGAGG EYMQQLFRSL MFQSQTSGFP FFPFMAPPPP QANPEKPPMV SPPNRINPMP 1030 1040 1050 1060 1070 1080 VGVGVGVPVP PGGPVKMVIK NGVLMPKQKQ RRYRTERPFA CEHCSARFTL RSNMERHVKQ 1090 1100 1110 1120 1130 1140 QHPQFYAQRE RSAHHVMRGR GASNVAAAAA AAAAAAAPTV MAGGPGSSGF GSNHHHGHGH 1150 1160 1170 1180 1190 1200 GSHGHAPISE QVKCAILAQQ LKAHKNTDLL QQALAHGSSS VAGNPLLHFG YPLTNPSPMH 1210 1220 1230 1240 1250 1260 NGSSQGNGQA TAMDDDEPKL IIDEDENEHD HEVEAEDVDD FEEDEDEEEM DEPEDEPELI 1270 1280 1290 1300 1310 1320 LDEQPAEKEA EEEQELPKPL EQLGTKEAAQ KMAETILEQA IKAGKPLSPP PTKENASPAN 1330 1340 1350 1360 1370 1380 PTVATTMQEP AITAPSTNPS SLKTMIAQAE YVGKSLKEVA SSPFKDESQD LVPVAKLVDN 1390 1400 1410 1420 1430 1440 ATSQNMGFNS YFRPSDVANH MEQSDEEGLV ASGSASESNN SGTEDVTSSS SSSEPKKKSA 1450 1460 1470 1480 1490 1500 YSLAPNRVSC PYCQRMFPWS SSLRRHILTH TGQKPFKCSH CPLLFTTKSN CDRHLLRKHG 1510 1520 1530 1540 1550 1560 NVESAMSVYV PTEDVSEPIP VPKSVEEIEL EEQRRRQEAE REKELELERE RELERERELE 1570 1580 1590 1600 1610 1620 RERQLEKEKE RERQQLIQKL AAQMNAAATA AAVVAAASAV NGGASGGPHG PIADALAGGD 1630 1640 1650 1660 1670 1680 LPYKCHLCEG SFAERLQCLE HIKQAHAHEY ALLLAKGAIE TESLEANPHQ QPSQQAVHSD 1690 1700 1710 1720 1730 1740 DEAPNGGGNR GKYPDYSNRK VICAFCLRRF WSTEDLRRHM RTHSGERPFQ CDICLRKFTL 1750 1760 1770 1780 1790 1800 KHSMLRHMKK HSGRAHNGDT PGSDCSDDEQ VSSPPSTPHP TQPTSANNNN SCHNNNNNAN 1810 1820 1830 1840 1850 1860 NNNNNNNNNN NNSSSKLGLK LHDLLDKASE WRASRLGEHK ENMGEATPSG ATVAGSDLIG 1870 1880 1890 1900 1910 1920 NLLGISDQGI LNKLLSSRTR RPNFWVWTTS ERNSSDNRAT PRAINTGVAA VLHRLTYTKA

References

[1]	"Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT." Yip M.L., Lamka M.L., Lipshitz H.D. Development 124:2129-2141(1997) [PubMed: 9187140] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U86010 mRNA. Translation: AAB95640.1.
PIR	T13893.
3D structure databases
HSSP	HSSP built from PDB template 2ADR based on UniProtKB P07248.
ProteinModelPortal	O46205.
SMR	O46205. Positions 249-357, 521-567, 677-826, 1048-1086, 1426-1499, 1615-1754.
ModBase	Search...
Protein-protein interaction databases
STRING	O46205.
Proteomic databases
PRIDE	O46205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0003053. peb.
Phylogenomic databases
eggNOG	NOG256116.
InParanoid	O46205.
OrthoDB	EOG4XSJ51.
Gene expression databases
ArrayExpress	O46205.
Bgee	O46205.
Family and domain databases
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 7 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 13 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O46205_DROME

Accession

Primary (citable) accession number: O46205

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 16, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)