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Protein

Accessory gland protein Acp62F

Gene

Acp62F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release.1 Publication

GO - Molecular functioni

  • peptidase inhibitor activity Source: FlyBase
  • serine-type endopeptidase inhibitor activity Source: FlyBase

GO - Biological processi

  • behavior Source: UniProtKB-KW
  • determination of adult lifespan Source: FlyBase
  • multicellular organism reproduction Source: FlyBase
  • negative regulation of endopeptidase activity Source: GOC
  • negative regulation of peptidase activity Source: GOC
  • negative regulation of proteolysis Source: FlyBase
  • regulation of proteolysis Source: FlyBase
  • sperm competition Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Behavior

Protein family/group databases

MEROPSiI08.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Accessory gland protein Acp62F
Gene namesi
Name:Acp62F
ORF Names:CG1262
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0020509. Acp62F.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 11591Accessory gland protein Acp62FPRO_0000034310Add
BLAST

Proteomic databases

PaxDbiO46202.
PRIDEiO46202.

Expressioni

Tissue specificityi

Seminal fluid.1 Publication

Gene expression databases

BgeeiO46202.
ExpressionAtlasiO46202. differential.
GenevisibleiO46202. DM.

Interactioni

Protein-protein interaction databases

BioGridi63842. 5 interactions.
DIPiDIP-20806N.
MINTiMINT-854371.
STRINGi7227.FBpp0072820.

Structurei

3D structure databases

ProteinModelPortaliO46202.
SMRiO46202. Positions 25-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 8855TILAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00540000073687.
HOGENOMiHOG000217509.
InParanoidiO46202.
OMAiRSDCPKD.
OrthoDBiEOG73V6J9.
PhylomeDBiO46202.

Family and domain databases

InterProiIPR002919. TIL_dom.
[Graphical view]
PfamiPF01826. TIL. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDMWSLKIC ACLGLLLLFK PIDSMGWQGP KVDCTANGTQ TECPVACPET
60 70 80 90 100
CEYSGNGPCV KMCGAPCVCK PGYVINERIP ACVLRSDCPK DVVRKEDMLL
110
GVSNFKCFSR NYNCS
Length:115
Mass (Da):12,570
Last modified:June 1, 1998 - v1
Checksum:i4326AA6F6C32291D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85763 mRNA. Translation: AAB96387.1.
AY344325 Genomic DNA. Translation: AAR05044.1.
AY344326 Genomic DNA. Translation: AAR05045.1.
AY344327 Genomic DNA. Translation: AAR05046.1.
AY344328 Genomic DNA. Translation: AAR05047.1.
AY344329 Genomic DNA. Translation: AAR05048.1.
AY344330 Genomic DNA. Translation: AAR05049.1.
AY344331 Genomic DNA. Translation: AAR05050.1.
AY344332 Genomic DNA. Translation: AAR05051.1.
AY344333 Genomic DNA. Translation: AAR05052.1.
AY344334 Genomic DNA. Translation: AAR05053.1.
AY344335 Genomic DNA. Translation: AAR05054.1.
AY344336 Genomic DNA. Translation: AAR05055.1.
AY344337 Genomic DNA. Translation: AAR05056.1.
AY344338 Genomic DNA. Translation: AAR05057.1.
AY344339 Genomic DNA. Translation: AAR05058.1.
AY344340 Genomic DNA. Translation: AAR05059.1.
AY344341 Genomic DNA. Translation: AAR05060.1.
AY344342 Genomic DNA. Translation: AAR05061.1.
AY344343 Genomic DNA. Translation: AAR05062.1.
AY344344 Genomic DNA. Translation: AAR05063.1.
AE014296 Genomic DNA. Translation: AAF47683.1.
AY010608 Genomic DNA. Translation: AAG35367.1.
AY010609 Genomic DNA. Translation: AAG35368.1.
AY010610 Genomic DNA. Translation: AAG35369.1.
AY010611 Genomic DNA. Translation: AAG35370.1.
AY010612 Genomic DNA. Translation: AAG35371.1.
AY010613 Genomic DNA. Translation: AAG35372.1.
AY010614 Genomic DNA. Translation: AAG35373.1.
AY010615 Genomic DNA. Translation: AAG35374.1.
AY010616 Genomic DNA. Translation: AAG35375.1.
AY010617 Genomic DNA. Translation: AAG35376.1.
RefSeqiNP_523892.1. NM_079168.3.
UniGeneiDm.2899.

Genome annotation databases

EnsemblMetazoaiFBtr0072943; FBpp0072820; FBgn0020509.
GeneIDi38340.
KEGGidme:Dmel_CG1262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85763 mRNA. Translation: AAB96387.1.
AY344325 Genomic DNA. Translation: AAR05044.1.
AY344326 Genomic DNA. Translation: AAR05045.1.
AY344327 Genomic DNA. Translation: AAR05046.1.
AY344328 Genomic DNA. Translation: AAR05047.1.
AY344329 Genomic DNA. Translation: AAR05048.1.
AY344330 Genomic DNA. Translation: AAR05049.1.
AY344331 Genomic DNA. Translation: AAR05050.1.
AY344332 Genomic DNA. Translation: AAR05051.1.
AY344333 Genomic DNA. Translation: AAR05052.1.
AY344334 Genomic DNA. Translation: AAR05053.1.
AY344335 Genomic DNA. Translation: AAR05054.1.
AY344336 Genomic DNA. Translation: AAR05055.1.
AY344337 Genomic DNA. Translation: AAR05056.1.
AY344338 Genomic DNA. Translation: AAR05057.1.
AY344339 Genomic DNA. Translation: AAR05058.1.
AY344340 Genomic DNA. Translation: AAR05059.1.
AY344341 Genomic DNA. Translation: AAR05060.1.
AY344342 Genomic DNA. Translation: AAR05061.1.
AY344343 Genomic DNA. Translation: AAR05062.1.
AY344344 Genomic DNA. Translation: AAR05063.1.
AE014296 Genomic DNA. Translation: AAF47683.1.
AY010608 Genomic DNA. Translation: AAG35367.1.
AY010609 Genomic DNA. Translation: AAG35368.1.
AY010610 Genomic DNA. Translation: AAG35369.1.
AY010611 Genomic DNA. Translation: AAG35370.1.
AY010612 Genomic DNA. Translation: AAG35371.1.
AY010613 Genomic DNA. Translation: AAG35372.1.
AY010614 Genomic DNA. Translation: AAG35373.1.
AY010615 Genomic DNA. Translation: AAG35374.1.
AY010616 Genomic DNA. Translation: AAG35375.1.
AY010617 Genomic DNA. Translation: AAG35376.1.
RefSeqiNP_523892.1. NM_079168.3.
UniGeneiDm.2899.

3D structure databases

ProteinModelPortaliO46202.
SMRiO46202. Positions 25-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63842. 5 interactions.
DIPiDIP-20806N.
MINTiMINT-854371.
STRINGi7227.FBpp0072820.

Protein family/group databases

MEROPSiI08.002.

Proteomic databases

PaxDbiO46202.
PRIDEiO46202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072943; FBpp0072820; FBgn0020509.
GeneIDi38340.
KEGGidme:Dmel_CG1262.

Organism-specific databases

CTDi38340.
FlyBaseiFBgn0020509. Acp62F.

Phylogenomic databases

GeneTreeiENSGT00540000073687.
HOGENOMiHOG000217509.
InParanoidiO46202.
OMAiRSDCPKD.
OrthoDBiEOG73V6J9.
PhylomeDBiO46202.

Miscellaneous databases

GenomeRNAii38340.
NextBioi808106.
PROiO46202.

Gene expression databases

BgeeiO46202.
ExpressionAtlasiO46202. differential.
GenevisibleiO46202. DM.

Family and domain databases

InterProiIPR002919. TIL_dom.
[Graphical view]
PfamiPF01826. TIL. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
    Strain: Canton-S.
    Tissue: Male accessory gland.
  2. "Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon."
    Panhuis T.M., Swanson W.J., Nunney L.
    Evolution 57:2785-2791(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3 and SFS 3.4.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "Molecular population genetics of male accessory gland proteins in Drosophila."
    Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G.
    Genetics 156:1879-1888(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 7-111.
    Strain: Zim62H-12C, Zim62H-16C, Zim62H-28C, Zim62H-30C, Zim62H-34C, Zim62I-10C, Zim62I-17C, Zim62I-18C, Zim62I-53C and Zim62I-5C.

Entry informationi

Entry nameiA62F_DROME
AccessioniPrimary (citable) accession number: O46202
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.