O46202 (A62F_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Accessory gland protein Acp62F

Gene names

Name:	Acp62F
ORF Names:	CG1262

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release. Ref.1
Subcellular location	Secreted Probable.
Tissue specificity	Seminal fluid. Ref.1
Sequence similarities	Contains 1 TIL (trypsin inhibitory-like) domain.

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	behavior Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of proteolysis Inferred from direct assay. Source: FlyBase sperm competition Inferred from mutant phenotype. Source: FlyBase
Cellular component	extracellular space Inferred from direct assay. Source: FlyBase
Molecular function	serine-type endopeptidase inhibitor activity Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 115	91	Accessory gland protein Acp62F		PRO_0000034310
Regions
	Domain	34 – 88	55	TIL

Sequences

	Sequence		Length	Mass (Da)
	O46202 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4326AA6F6C32291D	FASTA	115	12,570
	10 20 30 40 50 60 MTDMWSLKIC ACLGLLLLFK PIDSMGWQGP KVDCTANGTQ TECPVACPET CEYSGNGPCV 70 80 90 100 110 KMCGAPCVCK PGYVINERIP ACVLRSDCPK DVVRKEDMLL GVSNFKCFSR NYNCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New genes for male accessory gland proteins in Drosophila melanogaster." Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W., Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K. Insect Biochem. Mol. Biol. 27:825-834(1997) [PubMed: 9474779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY. Strain: Canton-S. Tissue: Male accessory gland.
[2]	"Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon." Panhuis T.M., Swanson W.J., Nunney L. Evolution 57:2785-2791(2003) [PubMed: 14761057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3 and SFS 3.4.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"Molecular population genetics of male accessory gland proteins in Drosophila." Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G. Genetics 156:1879-1888(2000) [PubMed: 11102381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 7-111. Strain: Zim62H-12C, Zim62H-16C, Zim62H-28C, Zim62H-30C, Zim62H-34C, Zim62I-10C, Zim62I-17C, Zim62I-18C, Zim62I-53C and Zim62I-5C.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85763 mRNA. Translation: AAB96387.1. AY344325 Genomic DNA. Translation: AAR05044.1. AY344326 Genomic DNA. Translation: AAR05045.1. AY344327 Genomic DNA. Translation: AAR05046.1. AY344328 Genomic DNA. Translation: AAR05047.1. AY344329 Genomic DNA. Translation: AAR05048.1. AY344330 Genomic DNA. Translation: AAR05049.1. AY344331 Genomic DNA. Translation: AAR05050.1. AY344332 Genomic DNA. Translation: AAR05051.1. AY344333 Genomic DNA. Translation: AAR05052.1. AY344334 Genomic DNA. Translation: AAR05053.1. AY344335 Genomic DNA. Translation: AAR05054.1. AY344336 Genomic DNA. Translation: AAR05055.1. AY344337 Genomic DNA. Translation: AAR05056.1. AY344338 Genomic DNA. Translation: AAR05057.1. AY344339 Genomic DNA. Translation: AAR05058.1. AY344340 Genomic DNA. Translation: AAR05059.1. AY344341 Genomic DNA. Translation: AAR05060.1. AY344342 Genomic DNA. Translation: AAR05061.1. AY344343 Genomic DNA. Translation: AAR05062.1. AY344344 Genomic DNA. Translation: AAR05063.1. AE014296 Genomic DNA. Translation: AAF47683.1. AY010608 Genomic DNA. Translation: AAG35367.1. AY010609 Genomic DNA. Translation: AAG35368.1. AY010610 Genomic DNA. Translation: AAG35369.1. AY010611 Genomic DNA. Translation: AAG35370.1. AY010612 Genomic DNA. Translation: AAG35371.1. AY010613 Genomic DNA. Translation: AAG35372.1. AY010614 Genomic DNA. Translation: AAG35373.1. AY010615 Genomic DNA. Translation: AAG35374.1. AY010616 Genomic DNA. Translation: AAG35375.1. AY010617 Genomic DNA. Translation: AAG35376.1.
RefSeq	NP_523892.1. NM_079168.3.
UniGene	Dm.2899.
3D structure databases
ProteinModelPortal	O46202.
SMR	O46202. Positions 32-89.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-20806N.
MINT	MINT-854371.
STRING	O46202.
Protein family/group databases
MEROPS	I08.002.
Proteomic databases
PRIDE	O46202.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0072943; FBpp0072820; FBgn0020509.
GeneID	38340.
KEGG	dme:Dmel_CG1262.
Organism-specific databases
CTD	38340.
FlyBase	FBgn0020509. Acp62F.
Phylogenomic databases
eggNOG	inNOG11668.
InParanoid	O46202.
OrthoDB	EOG41JWVP.
PhylomeDB	O46202.
Gene expression databases
Bgee	O46202.
GermOnline	CG1262. Drosophila melanogaster.
Family and domain databases
InterPro	IPR002919. Prot_Inh_CR_TIL. [Graphical view]
Pfam	PF01826. TIL. 1 hit. [Graphical view]
SUPFAM	SSF57567. Cysrich_TIL. 1 hit.
ProtoNet	Search...
Other
NextBio	808106.

Entry information

Entry name

A62F_DROME

Accession

Primary (citable) accession number: O46202

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project