O46200 (A63F_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Accessory gland protein Acp63F

Gene names

Name:	Acp63F
ORF Names:	CG10852

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Responsible for physiological and behavioral changes in mated female flies. Ref.1
Subcellular location	Secreted Probable.
Tissue specificity	Main cells of accessory gland and seminal fluid. Ref.1

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	behavior Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 81	65	Accessory gland protein Acp63F		PRO_0000020585
Natural variations
	Natural variant	39	1	N → S in strain: SFS 3.4.
	Natural variant	49	1	K → N in strain: Canton-S, NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3, SFS 3.4, Zim63H-12C, Zim63H-16C, Zim63H-28C, Zim63H-34C, Zim63I-10C, Zim63I-18C, Zim63I-53C and Zim63I-7C.
	Natural variant	72	1	L → V in strain: Zim63H-16C, Zim63H-34C and Zim63I-7C.
	Natural variant	73 – 74	2	HG → MA in strain: Zim63H-30C.
	Natural variant	73	1	H → Q in strain: Zim63H-16C and Zim63H-34C.
	Natural variant	75	1	K → E in strain: Zim63H-16C.
	Natural variant	76	1	P → T in strain: Zim63I-7C.

Sequences

	Sequence		Length	Mass (Da)
	O46200 [UniParc]. Last modified March 24, 2009. Version 2. Checksum: 0C53080311BA285B	FASTA	81	8,983
	10 20 30 40 50 60 MKAIIVFILF ISSVHAMSKC NQAIYLNLDP HCGILPDCNL DGPNPSYLKR VSCERKENGK 70 80 PGFIELIPGK CLHGKPRCSL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New genes for male accessory gland proteins in Drosophila melanogaster." Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W., Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K. Insect Biochem. Mol. Biol. 27:825-834(1997) [PubMed: 9474779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: Canton-S. Tissue: Male accessory gland.
[2]	"Molecular population genetics of male accessory gland proteins in Drosophila." Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G. Genetics 156:1879-1888(2000) [PubMed: 11102381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Zim63H-12C, Zim63H-16C, Zim63H-28C, Zim63H-30C, Zim63H-34C, Zim63I-10C, Zim63I-18C, Zim63I-53C and Zim63I-7C.
[3]	"Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon." Panhuis T.M., Swanson W.J., Nunney L. Evolution 57:2785-2791(2003) [PubMed: 14761057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3 and SFS 3.4.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[6]	Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85761 mRNA. Translation: AAB96385.1. AY010618 Genomic DNA. Translation: AAG37390.1. AY010619 Genomic DNA. Translation: AAG37391.1. AY010620 Genomic DNA. Translation: AAG37392.1. AY010621 Genomic DNA. Translation: AAG37393.1. AY010622 Genomic DNA. Translation: AAG37394.1. AY010623 Genomic DNA. Translation: AAG37395.1. AY010624 Genomic DNA. Translation: AAG37396.1. AY010625 Genomic DNA. Translation: AAG37397.1. AY010626 Genomic DNA. Translation: AAG37398.1. AY344345 Genomic DNA. Translation: AAR05064.1. AY344346 Genomic DNA. Translation: AAR05065.1. AY344347 Genomic DNA. Translation: AAR05066.1. AY344348 Genomic DNA. Translation: AAR05067.1. AY344349 Genomic DNA. Translation: AAR05068.1. AY344350 Genomic DNA. Translation: AAR05069.1. AY344351 Genomic DNA. Translation: AAR05070.1. AY344352 Genomic DNA. Translation: AAR05071.1. AY344353 Genomic DNA. Translation: AAR05072.1. AY344354 Genomic DNA. Translation: AAR05073.1. AY344355 Genomic DNA. Translation: AAR05074.1. AY344356 Genomic DNA. Translation: AAR05075.1. AY344357 Genomic DNA. Translation: AAR05076.1. AY344358 Genomic DNA. Translation: AAR05077.1. AY344359 Genomic DNA. Translation: AAR05078.1. AY344360 Genomic DNA. Translation: AAR05079.1. AY344361 Genomic DNA. Translation: AAR05080.1. AY344362 Genomic DNA. Translation: AAR05081.1. AY344363 Genomic DNA. Translation: AAR05082.1. AY344364 Genomic DNA. Translation: AAR05083.1. AE014296 Genomic DNA. Translation: AAF47797.2. BT053707 mRNA. Translation: ACK77625.1.
RefSeq	NP_523906.2. NM_079182.2.
UniGene	Dm.2560.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1006814.
STRING	O46200.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0073182; FBpp0073038; FBgn0015585.
GeneID	38448.
KEGG	dme:Dmel_CG10852.
Organism-specific databases
CTD	38448.
FlyBase	FBgn0015585. Acp63F.
Phylogenomic databases
OrthoDB	EOG4V41RD.
PhylomeDB	O46200.
Gene expression databases
Bgee	O46200.
GermOnline	CG10852. Drosophila melanogaster.
Family and domain databases
ProtoNet	Search...
Other
NextBio	808724.

Entry information

Entry name

A63F_DROME

Accession

Primary (citable) accession number: O46200
Secondary accession number(s): B7FNL7 , Q6VBE5, Q6VBE6, Q6VBE7, Q6VBE8, Q9VZM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project