Reviewed, UniProtKB/Swiss-Prot O46197 (A29AB_DROME)

Names and origin

Protein names

Recommended name:
    Accessory gland protein Acp29AB

Gene names

Name:	Acp29AB
ORF Names:	CG17797

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Responsible for physiological and behavioral changes in mated female flies.
Subcellular location	SecretedProbable.
Tissue specificity	Main cells of the accessory gland and in seminal fluid.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Lectin
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	behavior Inferred from electronic annotation. Source: UniProtKB-KW sperm displacement Non-traceable author statement. Source: FlyBase
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG10323	Q9V4B8	1	EBI-153710,EBI-145217
ERR	Q9VSE9	1	EBI-153710,EBI-166804
RnrS	P48592	1	EBI-153710,EBI-93696

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 234	213	Accessory gland protein Acp29AB		PRO_0000017556
Regions
	Domain	137 – 234	98	C-type lectin
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
	Disulfide bond	139 ↔ 228		By similarity
	Disulfide bond	207 ↔ 220		By similarity
Natural variations
	Natural variant	27	1	N → S in strain: SFS 1.2.
	Natural variant	29	1	K → N in strain: M26, Ma7, WS16 and WS26.
	Natural variant	59	1	K → R in strain: isofemale line 32, La1, La3, La4, La5, La14, La15, La16, La21, La25, La34, La35, M18, Ma5, Ma8, Ma13, Ma18, Ma20, Ma21, Ma45, Ma48, Ma52, Ma67, Mo1b, Mo52b, Mo80b, NFS 6.1, SFS 1.2, WS6, WS19, Zim26, Zim29, Zim30 and Zim56.
	Natural variant	104	1	K → E in strain: SFS 1.2.
	Natural variant	105	1	A → S in strain: La16 and La35.
	Natural variant	108	1	N → D in strain: SFS 2.3.
	Natural variant	113	1	R → L in strain: isofemale line 31, isofemale line 32, isofemale line 68, La14, La14, La16, La35, M01, M06, M09, M12, M26, M47, Ma5, Ma7, Ma13, Ma18, Ma20, Ma21, Ma45, Ma48, Ma50, Ma52, Ma67, Mo2b, Mo15b, Mo34a, Mo36a, Mo37a, Mo47a, Mo52b, Mo58b, Mo80b, NFS 5.1, NFS 5.2, NFS 5.4, NFS 6.2, NFS 6.3, NFS 6.4, SFS 1.1, SFS 1.3, SFS 1.4, SFS 2.2, SFS 3.1, SFS 3.3, WS1, WS6, WS9, WS12, WS16, WS26, WS47, WS56, Zim2, Zim26, Zim29, Zim30, Zim32, Zim37, Zim42 and Zim56.
	Natural variant	153	1	K → M in strain: Berkeley, isofemale line 32, La13, La14, La15, La16, M39, Ma5, Ma21, Ma45, Ma52, Ma67, Mo1b, Mo8b, Mo40b, Mo52b, NFS 5.3, NFS 6.1, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.4, SFS 2.3, SFS 2.4, SFS 3.2, SFS 3.4, Zim29, Zim30, Zim42 and Zim56.
	Natural variant	171	1	I → V in strain: NFS 5.2.
	Natural variant	214	1	E → D in strain: Ma7.

Sequences

	Sequence		Length	Mass (Da)
	O46197-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 8954CD3215480F3E	FASTA	234	27,173
	10 20 30 40 50 60 MYASNLLYLL ALWNLWDLSG GQQDIPNGKA TLPSPQTPQN TIDQIGINQN YWFTYNALKQ 70 80 90 100 110 120 NETLAIIDTM EMRIASSLLE FKAQMEIQLQ PLKIIMRHHA SNIKASNNIK MRRFEKVGSR 130 140 150 160 170 180 HFHIEKNLMQ TWFEAYVTCR KMNGHLANIQ DEKELDGILA LAPNNSYWID ISKLVENGGT 190 200 210 220 230 FVSTLTGREP FFVKWKSNQD TKKKNQCVYI YAKEMSYDEC FEKKSFVCQA DQWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New genes for male accessory gland proteins in Drosophila melanogaster." Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W., Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K. Insect Biochem. Mol. Biol. 27:825-834(1997) [PubMed: 9474779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: Canton-S. Tissue: Male accessory gland.
[2]	"Positive selection drives the evolution of the Acp29AB accessory gland protein in Drosophila." Aguade M. Genetics 152:543-551(1999) [PubMed: 10353898] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: La1, La13, La14, La15, La16, La21, La25, La3, La34, La35, La4, La5, La6, La9, Ma13, Ma18, Ma20, Ma21, Ma43, Ma45, Ma48, Ma5, Ma50, Ma52, Ma67, Ma7, Ma8, Mo15b, Mo1b, Mo2b, Mo34a, Mo36a, Mo37a, Mo40b, Mo47a, Mo52b, Mo58b, Mo80b and Mo8b.
[3]	"Molecular population genetics of male accessory gland proteins in Drosophila." Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G. Genetics 156:1879-1888(2000) [PubMed: 11102381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WS1, WS12, WS16, WS19, WS26, WS47, WS56, WS6, WS9, Zim2, Zim26, Zim29, Zim30, Zim32, Zim37, Zim42 and Zim56.
[4]	"Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon." Panhuis T.M., Swanson W.J., Nunney L. Evolution 57:2785-2791(2003) [PubMed: 14761057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3 and SFS 3.4.
[5]	"Molecular evolution and population genetics of duplicated accessory gland protein genes in Drosophila." Holloway A.K., Begun D.J. Mol. Biol. Evol. 21:1625-1628(2004) [PubMed: 15215320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M01, M06, M09, M12, M18, M39 and M47.
[6]	"Accessory gland protein involvement in post-mating inbreeding avoidance in Drosophila melanogaster." Panhuis T.M., Nunney L. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: isofemale line 31, isofemale line 32 and isofemale line 68.
[7]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[8]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U85758 mRNA. Translation: AAB96382.1. AJ240513 Genomic DNA. Translation: CAB53187.1. AJ240514 Genomic DNA. Translation: CAB53188.1. AJ240515 Genomic DNA. Translation: CAB53189.1. AJ240516 Genomic DNA. Translation: CAB53190.1. AJ240517 Genomic DNA. Translation: CAB53191.1. AJ240518 Genomic DNA. Translation: CAB53192.1. AJ240519 Genomic DNA. Translation: CAB53193.1. AJ240520 Genomic DNA. Translation: CAB53194.1. AJ240521 Genomic DNA. Translation: CAB53195.1. AJ240522 Genomic DNA. Translation: CAB53196.1. AJ240523 Genomic DNA. Translation: CAB53197.1. AJ240524 Genomic DNA. Translation: CAB53198.1. AJ240525 Genomic DNA. Translation: CAB53199.1. AJ240526 Genomic DNA. Translation: CAB53200.1. AJ240527 Genomic DNA. Translation: CAB53201.1. AJ240528 Genomic DNA. Translation: CAB53202.1. AJ240529 Genomic DNA. Translation: CAB53203.1. AJ240530 Genomic DNA. Translation: CAB53204.1. AJ240531 Genomic DNA. Translation: CAB53205.1. AJ240532 Genomic DNA. Translation: CAB53206.1. AJ240533 Genomic DNA. Translation: CAB53207.1. AJ240534 Genomic DNA. Translation: CAB53208.1. AJ240535 Genomic DNA. Translation: CAB53209.1. AJ240536 Genomic DNA. Translation: CAB53210.1. AJ240537 Genomic DNA. Translation: CAB53211.1. AJ240538 Genomic DNA. Translation: CAB53212.1. AJ240539 Genomic DNA. Translation: CAB53213.1. AJ240540 Genomic DNA. Translation: CAB53214.1. AJ240541 Genomic DNA. Translation: CAB53215.1. AJ240542 Genomic DNA. Translation: CAB53216.1. AJ240543 Genomic DNA. Translation: CAB53217.1. AJ240544 Genomic DNA. Translation: CAB53218.1. AJ240545 Genomic DNA. Translation: CAB53219.1. AJ240546 Genomic DNA. Translation: CAB53220.1. AJ240547 Genomic DNA. Translation: CAB53221.1. AJ240548 Genomic DNA. Translation: CAB53222.1. AJ240549 Genomic DNA. Translation: CAB53223.1. AJ240550 Genomic DNA. Translation: CAB53224.1. AJ240551 Genomic DNA. Translation: CAB53225.1. AY010527 Genomic DNA. Translation: AAG32559.1. AY010528 Genomic DNA. Translation: AAG32560.1. AY010529 Genomic DNA. Translation: AAG32561.1. AY010530 Genomic DNA. Translation: AAG32562.1. AY010531 Genomic DNA. Translation: AAG32563.1. AY010532 Genomic DNA. Translation: AAG32564.1. AY010533 Genomic DNA. Translation: AAG32565.1. AY010534 Genomic DNA. Translation: AAG32566.1. AY010535 Genomic DNA. Translation: AAG32567.1. AY010536 Genomic DNA. Translation: AAG32568.1. AY010537 Genomic DNA. Translation: AAG32569.1. AY010538 Genomic DNA. Translation: AAG32570.1. AY010539 Genomic DNA. Translation: AAG32571.1. AY010540 Genomic DNA. Translation: AAG32572.1. AY010541 Genomic DNA. Translation: AAG32573.1. AY010542 Genomic DNA. Translation: AAG32574.1. AY010543 Genomic DNA. Translation: AAG32575.1. AY344305 Genomic DNA. Translation: AAR05024.1. AY344306 Genomic DNA. Translation: AAR05025.1. AY344307 Genomic DNA. Translation: AAR05026.1. AY344308 Genomic DNA. Translation: AAR05027.1. AY344309 Genomic DNA. Translation: AAR05028.1. AY344310 Genomic DNA. Translation: AAR05029.1. AY344311 Genomic DNA. Translation: AAR05030.1. AY344312 Genomic DNA. Translation: AAR05031.1. AY344313 Genomic DNA. Translation: AAR05032.1. AY344314 Genomic DNA. Translation: AAR05033.1. AY344315 Genomic DNA. Translation: AAR05034.1. AY344316 Genomic DNA. Translation: AAR05035.1. AY344317 Genomic DNA. Translation: AAR05036.1. AY344318 Genomic DNA. Translation: AAR05037.1. AY344319 Genomic DNA. Translation: AAR05038.1. AY344320 Genomic DNA. Translation: AAR05039.1. AY344321 Genomic DNA. Translation: AAR05040.1. AY344322 Genomic DNA. Translation: AAR05041.1. AY344323 Genomic DNA. Translation: AAR05042.1. AY344324 Genomic DNA. Translation: AAR05043.1. AY635210 Genomic DNA. Translation: AAT49116.1. AY635211 Genomic DNA. Translation: AAT49117.1. AY635212 Genomic DNA. Translation: AAT49118.1. AY635213 Genomic DNA. Translation: AAT49119.1. AY635214 Genomic DNA. Translation: AAT49120.1. AY635215 Genomic DNA. Translation: AAT49121.1. AY635216 Genomic DNA. Translation: AAT49122.1. AY635217 Genomic DNA. Translation: AAT49123.1. DQ015761 Genomic DNA. Translation: AAY86166.1. DQ015762 Genomic DNA. Translation: AAY86167.1. DQ015763 Genomic DNA. Translation: AAY86168.1. AE014134 Genomic DNA. Translation: AAF52665.1.
RefSeq	NP_523512.2.
UniGene	Dm.2600
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O46197.
Genome annotation databases
Ensembl	CG17797. Drosophila melanogaster. [Contig view]
GeneID	34162.
KEGG	dme:Dmel_CG17797.
Organism-specific databases
FlyBase	FBgn0015583. Acp29AB.
Gene expression databases
GermOnline	CG17797. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	787184.

Entry information

Entry name

A29AB_DROME

Accession

Primary (citable) accession number: O46197
Secondary accession number(s): Q0HA35 , Q6GUY6, Q6GUY7, Q6GUY8, Q6GUZ1, Q6VBE9, Q6VBF0, Q6VBF1, Q6VBF2, Q6VBF4, Q6VBF5, Q6VBF6, Q6VBF7, Q9TVT3, Q9TW05, Q9TW06, Q9TW07, Q9U976, Q9U977, Q9U978, Q9U979, Q9V3Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project