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Protein

Serine protease inhibitor 3

Gene
N/A
Organism
Schistocerca gregaria (Desert locust)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In vitro, active against alpha-chymotrypsin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei49 – 50Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI19.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor 3
Alternative name(s):
Protease inhibitor SGPI-3
Serine protease inhibitor III
OrganismiSchistocerca gregaria (Desert locust)
Taxonomic identifieri7010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PeptideiPRO_000002671224 – 63Serine protease inhibitor 3Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi37 ↔ 47PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in hemolymph, ovaries, testes and fat body of adults but are absent in the gut. Also present in larval hemolymph and fat body.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 55PacifastinPROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the protease inhibitor I19 family. [View classification]PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiView protein in InterPro
IPR008037. Pacifastin_dom.
PfamiView protein in Pfam
PF05375. Pacifastin_I. 1 hit.
SUPFAMiSSF57283. SSF57283. 1 hit.
PROSITEiView protein in PROSITE
PS51446. PACIFASTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLAVFLV LLIAALVCEQ ALACTPGSRK YDGCNWCTCS SGGAWICTLK
60
YCPPSSGGGL TFA
Length:63
Mass (Da):6,533
Last modified:June 1, 1998 - v1
Checksum:iEE46BACCD7441A6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09606 mRNA. Translation: CAA70819.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09606 mRNA. Translation: CAA70819.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI19.012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR008037. Pacifastin_dom.
PfamiView protein in Pfam
PF05375. Pacifastin_I. 1 hit.
SUPFAMiSSF57283. SSF57283. 1 hit.
PROSITEiView protein in PROSITE
PS51446. PACIFASTIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSGP3_SCHGR
AccessioniPrimary (citable) accession number: O46163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: February 15, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.