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Protein

Serine protease inhibitor I/II

Gene
N/A
Organism
Schistocerca gregaria (Desert locust)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In vitro, SGPI-1/SGCI is active against alpha-chymotrypsin and trypsin while SGPI-2/SGTI is active against alpha-chymotrypsin and pancreatic elastase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bond2
Sitei86 – 87Reactive bond2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI19.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor I/II
Cleaved into the following 2 chains:
Alternative name(s):
Schistocerca gregaria trypsin inhibitor
Short name:
SGTI
Alternative name(s):
Schistocerca gregaria chymotrypsin inhibitor
Short name:
SGCI
OrganismiSchistocerca gregaria (Desert locust)
Taxonomic identifieri7010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000002671020 – 54Protease inhibitor SGPI-1Add BLAST35
PeptideiPRO_000002671157 – 91Protease inhibitor SGPI-2Add BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 381 Publication
Disulfide bondi33 ↔ 511 Publication
Disulfide bondi36 ↔ 461 Publication
Disulfide bondi60 ↔ 751 Publication
Disulfide bondi70 ↔ 891 Publication
Disulfide bondi73 ↔ 841 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed in hemolymph, ovaries, testes and fat body of adults but are absent in the gut. Also present in larval hemolymph and fat body.1 Publication

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 31Combined sources4
Beta strandi34 – 38Combined sources5
Beta strandi44 – 47Combined sources4
Turni62 – 64Combined sources3
Beta strandi65 – 68Combined sources4
Beta strandi71 – 75Combined sources5
Beta strandi77 – 80Combined sources4
Beta strandi82 – 85Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KGMNMR-A57-91[»]
1KIONMR-A57-91[»]
1KJ0NMR-A20-54[»]
2F91X-ray1.20B20-54[»]
2XTTX-ray0.93A20-54[»]
3TVJX-ray1.28I57-91[»]
4DJZX-ray3.20H/I57-87[»]
ProteinModelPortaliO46162.
SMRiO46162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO46162.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 54Pacifastin 1PROSITE-ProRule annotationAdd BLAST35
Domaini57 – 92Pacifastin 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the protease inhibitor I19 family. [View classification]PROSITE-ProRule annotation
Contains 2 pacifastin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR008037. Pacifastin_dom.
[Graphical view]
PfamiPF05375. Pacifastin_I. 2 hits.
[Graphical view]
SUPFAMiSSF57283. SSF57283. 2 hits.
PROSITEiPS51446. PACIFASTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLALALCAA FLLVVLVQAE QECTPGQTKK QDCNTCNCTP TGVWACTRKG
60 70 80 90
CPPHKREVTC EPGTTFKDKC NTCRCGSDGK SAACTLKACP QK
Length:92
Mass (Da):9,842
Last modified:June 1, 1998 - v1
Checksum:i9E5A228C767C657C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09605 mRNA. Translation: CAA70818.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09605 mRNA. Translation: CAA70818.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KGMNMR-A57-91[»]
1KIONMR-A57-91[»]
1KJ0NMR-A20-54[»]
2F91X-ray1.20B20-54[»]
2XTTX-ray0.93A20-54[»]
3TVJX-ray1.28I57-91[»]
4DJZX-ray3.20H/I57-87[»]
ProteinModelPortaliO46162.
SMRiO46162.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI19.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO46162.

Family and domain databases

InterProiIPR008037. Pacifastin_dom.
[Graphical view]
PfamiPF05375. Pacifastin_I. 2 hits.
[Graphical view]
SUPFAMiSSF57283. SSF57283. 2 hits.
PROSITEiPS51446. PACIFASTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGP1_SCHGR
AccessioniPrimary (citable) accession number: O46162
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.