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O46162

- SGP1_SCHGR

UniProt

O46162 - SGP1_SCHGR

Protein

Serine protease inhibitor I/II

Gene
N/A
Organism
Schistocerca gregaria (Desert locust)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    In vitro, SGPI-1/SGCI is active against alpha-chymotrypsin and trypsin while SGPI-2/SGTI is active against alpha-chymotrypsin and pancreatic elastase.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei48 – 492Reactive bond
    Sitei86 – 872Reactive bond

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI19.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine protease inhibitor I/II
    Cleaved into the following 2 chains:
    Alternative name(s):
    Schistocerca gregaria trypsin inhibitor
    Short name:
    SGTI
    Alternative name(s):
    Schistocerca gregaria chymotrypsin inhibitor
    Short name:
    SGCI
    OrganismiSchistocerca gregaria (Desert locust)
    Taxonomic identifieri7010 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Peptidei20 – 5435Protease inhibitor SGPI-1PRO_0000026710Add
    BLAST
    Peptidei57 – 9135Protease inhibitor SGPI-2PRO_0000026711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 38
    Disulfide bondi33 ↔ 51
    Disulfide bondi36 ↔ 46
    Disulfide bondi60 ↔ 75
    Disulfide bondi70 ↔ 89
    Disulfide bondi73 ↔ 84

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed in hemolymph, ovaries, testes and fat body of adults but are absent in the gut. Also present in larval hemolymph and fat body.1 Publication

    Structurei

    Secondary structure

    1
    92
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 314
    Beta strandi34 – 385
    Beta strandi44 – 474
    Turni62 – 643
    Beta strandi65 – 684
    Beta strandi71 – 755
    Beta strandi77 – 804
    Beta strandi82 – 854

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KGMNMR-A57-91[»]
    1KIONMR-A57-91[»]
    1KJ0NMR-A20-54[»]
    2F91X-ray1.20B20-54[»]
    2XTTX-ray0.93A20-54[»]
    3TVJX-ray1.28I57-91[»]
    4DJZX-ray3.20H/I57-87[»]
    ProteinModelPortaliO46162.
    SMRiO46162. Positions 20-54, 57-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO46162.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 5435Pacifastin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini57 – 9236Pacifastin 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protease inhibitor I19 family. [View classification]PROSITE-ProRule annotation
    Contains 2 pacifastin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    InterProiIPR020862. Pacifastin_art.
    IPR008037. Prot_inh_PMP.
    IPR016307. Prtase-inh_pacifastin.
    [Graphical view]
    PfamiPF05375. Pacifastin_I. 2 hits.
    [Graphical view]
    PIRSFiPIRSF001625. Prot_inhib_pacifastin. 1 hit.
    SUPFAMiSSF57283. SSF57283. 2 hits.
    PROSITEiPS51446. PACIFASTIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O46162-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLALALCAA FLLVVLVQAE QECTPGQTKK QDCNTCNCTP TGVWACTRKG   50
    CPPHKREVTC EPGTTFKDKC NTCRCGSDGK SAACTLKACP QK 92
    Length:92
    Mass (Da):9,842
    Last modified:June 1, 1998 - v1
    Checksum:i9E5A228C767C657C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09605 mRNA. Translation: CAA70818.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09605 mRNA. Translation: CAA70818.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KGM NMR - A 57-91 [» ]
    1KIO NMR - A 57-91 [» ]
    1KJ0 NMR - A 20-54 [» ]
    2F91 X-ray 1.20 B 20-54 [» ]
    2XTT X-ray 0.93 A 20-54 [» ]
    3TVJ X-ray 1.28 I 57-91 [» ]
    4DJZ X-ray 3.20 H/I 57-87 [» ]
    ProteinModelPortali O46162.
    SMRi O46162. Positions 20-54, 57-91.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I19.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei O46162.

    Family and domain databases

    InterProi IPR020862. Pacifastin_art.
    IPR008037. Prot_inh_PMP.
    IPR016307. Prtase-inh_pacifastin.
    [Graphical view ]
    Pfami PF05375. Pacifastin_I. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF001625. Prot_inhib_pacifastin. 1 hit.
    SUPFAMi SSF57283. SSF57283. 2 hits.
    PROSITEi PS51446. PACIFASTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two cDNAs encoding three small serine protease inhibiting peptides from the desert locust Schistocerca gregaria and analysis of tissue-dependent and stage-dependent expression."
      Vanden Broeck J., Chiou S.-J., Schoofs L., Hamdaoui A., Vandenbussche F., Simonet G., Wataleb S., De Loof A.
      Eur. J. Biochem. 254:90-95(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Purification and characterization of a group of five novel peptide serine protease inhibitors from ovaries of the desert locust, Schistocerca gregaria."
      Hamdaoui A., Wataleb S., Devreese B., Chiou S.-J., Vanden Broeck J., Van Beeumen J., De Loof A., Schoofs L.
      FEBS Lett. 422:74-78(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-54 AND 57-91, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Ovary.
    3. "Structural and functional properties of a novel serine protease inhibiting peptide family in arthropods."
      Simonet G., Claeys I., Vanden Broeck J.
      Comp. Biochem. Physiol. 132B:247-255(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 20-54 AND 57-91.

    Entry informationi

    Entry nameiSGP1_SCHGR
    AccessioniPrimary (citable) accession number: O46162
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3