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Protein

Ferritin heavy chain

Gene
N/A
Organism
Echinococcus granulosus (Hydatid tapeworm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Iron 1PROSITE-ProRule annotation1
Metal bindingi58Iron 1PROSITE-ProRule annotation1
Metal bindingi58Iron 2PROSITE-ProRule annotation1
Metal bindingi61Iron 1PROSITE-ProRule annotation1
Metal bindingi103Iron 2PROSITE-ProRule annotation1
Metal bindingi137Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
OrganismiEchinococcus granulosus (Hydatid tapeworm)
Taxonomic identifieri6210 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010811 – 173Ferritin heavy chainAdd BLAST173

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO46119.
SMRiO46119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR012347. Ferritin-like.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

O46119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVRQNFHE ECERGINRQI NMELYASYLY LAMSQHFDRD DVALPGFREF
60 70 80 90 100
FAKASEEERE HAIKLMRYQC GRGGRIVYQD IAKPQTTEWA SGLEAMEMAL
110 120 130 140 150
KIEREVNESL LALRGVANKN NDSQFCEFLE GEFLGEQVSD IKKLAGYVTN
160 170
LKRCGPGLGE YIFDKETLQG GEK
Length:173
Mass (Da):19,845
Last modified:June 1, 1998 - v1
Checksum:i604AA139AEC34A53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31712 mRNA. Translation: CAA83506.1.

Similar proteinsi

Entry informationi

Entry nameiFRIH_ECHGR
AccessioniPrimary (citable) accession number: O46119
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 1998
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families