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O46119

- FRIH_ECHGR

UniProt

O46119 - FRIH_ECHGR

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Protein
Ferritin heavy chain
Gene
N/A
Organism
Echinococcus granulosus (Hydatid tapeworm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Iron 1 By similarity
Metal bindingi58 – 581Iron 1 By similarity
Metal bindingi58 – 581Iron 2 By similarity
Metal bindingi61 – 611Iron 1 By similarity
Metal bindingi103 – 1031Iron 2 By similarity
Metal bindingi137 – 1371Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain (EC:1.16.3.1)
OrganismiEchinococcus granulosus (Hydatid tapeworm)
Taxonomic identifieri6210 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Ferritin heavy chain
PRO_0000201081Add
BLAST

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Structurei

3D structure databases

ProteinModelPortaliO46119.
SMRiO46119. Positions 2-168.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46119-1 [UniParc]FASTAAdd to Basket

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MSLVRQNFHE ECERGINRQI NMELYASYLY LAMSQHFDRD DVALPGFREF    50
FAKASEEERE HAIKLMRYQC GRGGRIVYQD IAKPQTTEWA SGLEAMEMAL 100
KIEREVNESL LALRGVANKN NDSQFCEFLE GEFLGEQVSD IKKLAGYVTN 150
LKRCGPGLGE YIFDKETLQG GEK 173
Length:173
Mass (Da):19,845
Last modified:June 1, 1998 - v1
Checksum:i604AA139AEC34A53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z31712 mRNA. Translation: CAA83506.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z31712 mRNA. Translation: CAA83506.1 .

3D structure databases

ProteinModelPortali O46119.
SMRi O46119. Positions 2-168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and immunological characterisation of Echinococcus granulosus ferritin."
    Ersfeld K., Craig P.S.
    Parasitol. Res. 81:382-387(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFRIH_ECHGR
AccessioniPrimary (citable) accession number: O46119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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