Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O46119 (FRIH_ECHGR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin heavy chain

EC=1.16.3.1
OrganismEchinococcus granulosus (Hydatid tapeworm)
Taxonomic identifier6210 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173Ferritin heavy chain
PRO_0000201081

Regions

Domain6 – 155150Ferritin-like diiron

Sites

Metal binding231Iron 1 By similarity
Metal binding581Iron 1 By similarity
Metal binding581Iron 2 By similarity
Metal binding611Iron 1 By similarity
Metal binding1031Iron 2 By similarity
Metal binding1371Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O46119 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 604AA139AEC34A53

FASTA17319,845
        10         20         30         40         50         60 
MSLVRQNFHE ECERGINRQI NMELYASYLY LAMSQHFDRD DVALPGFREF FAKASEEERE 

        70         80         90        100        110        120 
HAIKLMRYQC GRGGRIVYQD IAKPQTTEWA SGLEAMEMAL KIEREVNESL LALRGVANKN 

       130        140        150        160        170 
NDSQFCEFLE GEFLGEQVSD IKKLAGYVTN LKRCGPGLGE YIFDKETLQG GEK 

« Hide

References

[1]"Cloning and immunological characterisation of Echinococcus granulosus ferritin."
Ersfeld K., Craig P.S.
Parasitol. Res. 81:382-387(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z31712 mRNA. Translation: CAA83506.1.

3D structure databases

ProteinModelPortalO46119.
SMRO46119. Positions 2-168.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIH_ECHGR
AccessionPrimary (citable) accession number: O46119
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families