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Protein
Submitted name:

Ubiquitin activating enzyme

Gene

Uba1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei584Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin activating enzyme activity Source: FlyBase

GO - Biological processi

  • autophagy Source: FlyBase
  • cell proliferation Source: FlyBase
  • larval midgut cell programmed cell death Source: FlyBase
  • lipid storage Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuron remodeling Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • protein polyubiquitination Source: FlyBase
  • protein ubiquitination Source: FlyBase
  • regulation of growth Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • regulation of Ras protein signal transduction Source: FlyBase

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1169408 ISG15 antiviral mechanism
R-DME-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin activating enzymeImported
Gene namesi
Name:Uba1Imported
Synonyms:UBA-1Imported
ORF Names:CG1782Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0023143 Uba1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiO46111
PRIDEiO46111

Expressioni

Gene expression databases

BgeeiFBgn0023143
ExpressionAtlasiO46111 differential

Interactioni

Protein-protein interaction databases

IntActiO46111, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliO46111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini878 – 1003UBA_e1_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2012 Eukaryota
COG0476 LUCA
HOGENOMiHOG000069241
OrthoDBiEOG091G0130

Family and domain databases

Gene3Di3.10.290.60, 1 hit
InterProiView protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR035985 Ubiquitin-activating_enz
IPR018075 UBQ-activ_enz_E1
IPR018074 UBQ-activ_enz_E1_CS
IPR033127 UBQ-activ_enz_E1_Cys_AS
IPR000011 UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit
PRINTSiPR01849 UBIQUITINACT
SMARTiView protein in SMART
SM00985 UBA_e1_C, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
TIGRFAMsiTIGR01408 Ube1, 1 hit
PROSITEiView protein in PROSITE
PS00536 UBIQUITIN_ACTIVAT_1, 1 hit
PS00865 UBIQUITIN_ACTIVAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

O46111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNSAAAGG DIDESLYSRQ LYVLGHDAMR RMANSDILLS GLGGLGLEIA
60 70 80 90 100
KNVILGGVKS ITLHDTATCG LHDLSSQFYL TEADIAKNRA EASCAQLAEL
110 120 130 140 150
NNYVRTVSHT GPLTEEFLRK FRVVVLTNSD GEEQQRIAKF GHENGIALII
160 170 180 190 200
AETRGLFAKV FCDFGETFTI YDPDGTQPIS TMIASITHDA QGVVTCLDET
210 220 230 240 250
RHGFNDGDLL TFSEVQGMQE LNGCQPLKIT VLGPYTFSIG DTSKFGEYMS
260 270 280 290 300
GGVATQVKMP KTISFKPLAQ ATEEPEFLIS DFAKLDSPAT LHVAFNALSS
310 320 330 340 350
YRKAHNGALP RPWNEEDANS FLEVVRASSN AEVDEKLVLQ FAKICSGNTC
360 370 380 390 400
PLDAAVGGIV AQEVLKACSG KFTPIYQWLY FDALECLPTE GVEEADAQPV
410 420 430 440 450
GSRYDSQIAI FGKKFQEKLA DSKWFIVGAG AIGCELLKNF GMLGLGTGNG
460 470 480 490 500
QIFVTDMDLI EKSNLNRQFL FRPHDVQKPK SMTAADAIKR MNPEVNVTAY
510 520 530 540 550
ELRVGAETEK VFSEDFFGKL DGVANALDNV DARIYMDRKC IFNRIPLVET
560 570 580 590 600
GTLGTLGNVQ VIVPFATESY SSSQDPPEKS IPICTLKNFP NAIEHTLQWA
610 620 630 640 650
RDAFEGVFKQ SAENAAQYIA DPQFTERIAK LPGIQPLEIL DSIKKALIDD
660 670 680 690 700
KPKSFAHCVE WARLYWEDQY VNQIKQLLFN FPPDQITSSG QPFWSGPKQC
710 720 730 740 750
PDPLVFDVND PMHLDFIYAA ANLRAEVYGI EQVRNRETIA ELVQKVKVPE
760 770 780 790 800
FKPRSGVKIE TNEAAAAASA NNFDDGELDQ DRVDKIISEL LKNADKSSKI
810 820 830 840 850
TPLEFEKDDD SNLHMDFIVA CSNLRAANYK IPPADRHKSK LIAGKIIPAI
860 870 880 890 900
ATTTSVLSGL ACLEVIKLIV GHRDLVKFKK PCANLALPFM AFSEPLPAAK
910 920 930 940 950
NTYYGKEWTL WDRFEVTGEL SLQEFLNYFE ENEKLKITML SQGVSMLYSF
960 970 980 990 1000
FMPKAKCSER LPLPMSEVVR RVSKRRLEPH ERSLVFEICC NDVDGEDVEV

PYVRYTLP
Length:1,008
Mass (Da):111,690
Last modified:June 1, 1998 - v1
Checksum:i96A6E3AD53593F8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15895 mRNA Translation: CAA75816.1

Similar proteinsi

Entry informationi

Entry nameiO46111_DROME
AccessioniPrimary (citable) accession number: O46111
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health