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Protein
Submitted name:

Ubiquitin activating enzyme

Gene

Uba1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin activating enzyme activity Source: FlyBase

GO - Biological processi

  • autophagy Source: FlyBase
  • cell proliferation Source: FlyBase
  • larval midgut cell programmed cell death Source: FlyBase
  • lipid storage Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuron remodeling Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • protein polyubiquitination Source: FlyBase
  • protein ubiquitination Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of growth Source: FlyBase
  • regulation of programmed cell death Source: FlyBase
  • regulation of Ras protein signal transduction Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1169408. ISG15 antiviral mechanism.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin activating enzymeImported
Gene namesi
Name:Uba1Imported
Synonyms:UBA-1Imported
ORF Names:CG1782Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0023143. Uba1.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO46111.
PeptideAtlasiO46111.
PRIDEiO46111.

Expressioni

Gene expression databases

BgeeiO46111.
ExpressionAtlasiO46111. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087583.

Structurei

3D structure databases

ProteinModelPortaliO46111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini878 – 1003126UBA_e1_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2012. Eukaryota.
COG0476. LUCA.
HOGENOMiHOG000069241.
OrthoDBiEOG74R1PV.

Family and domain databases

Gene3Di1.10.3240.10. 2 hits.
3.40.50.720. 4 hits.
InterProiIPR032420. E1_4HB.
IPR032418. E1_FCCH.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
IPR018965. Ub-activating_enz_E1_C.
IPR019572. UBA_E1_Cys.
IPR018075. UBQ-activ_enz_E1.
IPR018074. UBQ-activ_enz_E1_CS.
IPR033127. UBQ-activ_enz_E1_Cys_AS.
IPR000011. UBQ/SUMO-activ_enz_E1-like.
[Graphical view]
PfamiPF16191. E1_4HB. 1 hit.
PF16190. E1_FCCH. 1 hit.
PF09358. E1_UFD. 1 hit.
PF00899. ThiF. 2 hits.
PF10585. UBA_e1_thiolCys. 1 hit.
[Graphical view]
PRINTSiPR01849. UBIQUITINACT.
SMARTiSM00985. UBA_e1_C. 1 hit.
[Graphical view]
SUPFAMiSSF69572. SSF69572. 2 hits.
TIGRFAMsiTIGR01408. Ube1. 1 hit.
PROSITEiPS00536. UBIQUITIN_ACTIVAT_1. 1 hit.
PS00865. UBIQUITIN_ACTIVAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNSAAAGG DIDESLYSRQ LYVLGHDAMR RMANSDILLS GLGGLGLEIA
60 70 80 90 100
KNVILGGVKS ITLHDTATCG LHDLSSQFYL TEADIAKNRA EASCAQLAEL
110 120 130 140 150
NNYVRTVSHT GPLTEEFLRK FRVVVLTNSD GEEQQRIAKF GHENGIALII
160 170 180 190 200
AETRGLFAKV FCDFGETFTI YDPDGTQPIS TMIASITHDA QGVVTCLDET
210 220 230 240 250
RHGFNDGDLL TFSEVQGMQE LNGCQPLKIT VLGPYTFSIG DTSKFGEYMS
260 270 280 290 300
GGVATQVKMP KTISFKPLAQ ATEEPEFLIS DFAKLDSPAT LHVAFNALSS
310 320 330 340 350
YRKAHNGALP RPWNEEDANS FLEVVRASSN AEVDEKLVLQ FAKICSGNTC
360 370 380 390 400
PLDAAVGGIV AQEVLKACSG KFTPIYQWLY FDALECLPTE GVEEADAQPV
410 420 430 440 450
GSRYDSQIAI FGKKFQEKLA DSKWFIVGAG AIGCELLKNF GMLGLGTGNG
460 470 480 490 500
QIFVTDMDLI EKSNLNRQFL FRPHDVQKPK SMTAADAIKR MNPEVNVTAY
510 520 530 540 550
ELRVGAETEK VFSEDFFGKL DGVANALDNV DARIYMDRKC IFNRIPLVET
560 570 580 590 600
GTLGTLGNVQ VIVPFATESY SSSQDPPEKS IPICTLKNFP NAIEHTLQWA
610 620 630 640 650
RDAFEGVFKQ SAENAAQYIA DPQFTERIAK LPGIQPLEIL DSIKKALIDD
660 670 680 690 700
KPKSFAHCVE WARLYWEDQY VNQIKQLLFN FPPDQITSSG QPFWSGPKQC
710 720 730 740 750
PDPLVFDVND PMHLDFIYAA ANLRAEVYGI EQVRNRETIA ELVQKVKVPE
760 770 780 790 800
FKPRSGVKIE TNEAAAAASA NNFDDGELDQ DRVDKIISEL LKNADKSSKI
810 820 830 840 850
TPLEFEKDDD SNLHMDFIVA CSNLRAANYK IPPADRHKSK LIAGKIIPAI
860 870 880 890 900
ATTTSVLSGL ACLEVIKLIV GHRDLVKFKK PCANLALPFM AFSEPLPAAK
910 920 930 940 950
NTYYGKEWTL WDRFEVTGEL SLQEFLNYFE ENEKLKITML SQGVSMLYSF
960 970 980 990 1000
FMPKAKCSER LPLPMSEVVR RVSKRRLEPH ERSLVFEICC NDVDGEDVEV

PYVRYTLP
Length:1,008
Mass (Da):111,690
Last modified:June 1, 1998 - v1
Checksum:i96A6E3AD53593F8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15895 mRNA. Translation: CAA75816.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15895 mRNA. Translation: CAA75816.1.

3D structure databases

ProteinModelPortaliO46111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087583.

Proteomic databases

PaxDbiO46111.
PeptideAtlasiO46111.
PRIDEiO46111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0023143. Uba1.

Phylogenomic databases

eggNOGiKOG2012. Eukaryota.
COG0476. LUCA.
HOGENOMiHOG000069241.
OrthoDBiEOG74R1PV.

Enzyme and pathway databases

ReactomeiR-DME-1169408. ISG15 antiviral mechanism.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiO46111.
ExpressionAtlasiO46111. differential.

Family and domain databases

Gene3Di1.10.3240.10. 2 hits.
3.40.50.720. 4 hits.
InterProiIPR032420. E1_4HB.
IPR032418. E1_FCCH.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
IPR018965. Ub-activating_enz_E1_C.
IPR019572. UBA_E1_Cys.
IPR018075. UBQ-activ_enz_E1.
IPR018074. UBQ-activ_enz_E1_CS.
IPR033127. UBQ-activ_enz_E1_Cys_AS.
IPR000011. UBQ/SUMO-activ_enz_E1-like.
[Graphical view]
PfamiPF16191. E1_4HB. 1 hit.
PF16190. E1_FCCH. 1 hit.
PF09358. E1_UFD. 1 hit.
PF00899. ThiF. 2 hits.
PF10585. UBA_e1_thiolCys. 1 hit.
[Graphical view]
PRINTSiPR01849. UBIQUITINACT.
SMARTiSM00985. UBA_e1_C. 1 hit.
[Graphical view]
SUPFAMiSSF69572. SSF69572. 2 hits.
TIGRFAMsiTIGR01408. Ube1. 1 hit.
PROSITEiPS00536. UBIQUITIN_ACTIVAT_1. 1 hit.
PS00865. UBIQUITIN_ACTIVAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Drosophila ubiquitin activating enzyme."
    zur Lage P., Hartswood E., Bownes M., Finnegan D.J.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton-SImported.
    Tissue: BrainImported, Imaginal discImported and OvaryImported.
  2. Zur Lage P.I.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton-SImported.
    Tissue: BrainImported, Imaginal discImported and OvaryImported.

Entry informationi

Entry nameiO46111_DROME
AccessioniPrimary (citable) accession number: O46111
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.