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Protein

Lipase 3

Gene

Lip3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164Charge relay systemPROSITE-ProRule annotation1
Active sitei369Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-171052. LDL-mediated lipid transport.
R-DME-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERidrome-lip3. Acidic_Lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase 3 (EC:3.1.1.-)
Short name:
DmLip3
Gene namesi
Name:Lip3
ORF Names:CG8823
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0023495. Lip3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001781121 – 394Lipase 3Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO46108.
PRIDEiO46108.

Expressioni

Tissue specificityi

Fat body.1 Publication

Developmental stagei

Only at larval stages.1 Publication

Gene expression databases

BgeeiFBgn0023495.
GenevisibleiO46108. DM.

Interactioni

Protein-protein interaction databases

BioGridi66726. 13 interactors.
IntActiO46108. 12 interactors.
MINTiMINT-4080713.
STRINGi7227.FBpp0082239.

Structurei

3D structure databases

ProteinModelPortaliO46108.
SMRiO46108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
InParanoidiO46108.
OMAiDWMCDVS.
OrthoDBiEOG091G09AX.
PhylomeDBiO46108.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF04083. Abhydro_lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O46108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRGALKVTI LLVGLGLVLA GSRPISDCGE RIEDDGYPME RHEVVTSDNY
60 70 80 90 100
ILTMHRIPYS PKTGESSNRP VAFLMHGMLS SSSDWVLMGP ERSLAYMLAD
110 120 130 140 150
AGYDVWMGNA RGNTYSKAHK YWPTYWQIFW NFSWNEIGMY DVPAMIDYVL
160 170 180 190 200
AKTGQQQVQY VGHSQGTTVY LVMVSERPEY NDKIKSAHLL GPAAYMGNMK
210 220 230 240 250
SPLTRAFAPI LGQPNAIVEV CGSMEFMPSN KFKQDLGIEM CQATSPYADM
260 270 280 290 300
CANEIFLIGG YDTEQLDYEL LEHIKATSPA GASVNQNLHF CQEYNSGKFR
310 320 330 340 350
KFDYTALRNP YEYGSYFPPD YKLKNAKAPV LLYYGANDWM CDVSDVRKLR
360 370 380 390
DELPNMALDY LVPFEKWAHL DFIWGTEARK YVYDEVLKQM QSYE
Length:394
Mass (Da):44,901
Last modified:June 1, 1998 - v1
Checksum:iA718D1D743673802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14367 mRNA. Translation: CAA74737.1.
AE014297 Genomic DNA. Translation: AAF54935.1.
BT023257 mRNA. Translation: AAY55673.1.
RefSeqiNP_477331.1. NM_057983.4.
UniGeneiDm.2990.

Genome annotation databases

EnsemblMetazoaiFBtr0082771; FBpp0082239; FBgn0023495.
GeneIDi41643.
KEGGidme:Dmel_CG8823.
UCSCiCG8823-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14367 mRNA. Translation: CAA74737.1.
AE014297 Genomic DNA. Translation: AAF54935.1.
BT023257 mRNA. Translation: AAY55673.1.
RefSeqiNP_477331.1. NM_057983.4.
UniGeneiDm.2990.

3D structure databases

ProteinModelPortaliO46108.
SMRiO46108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66726. 13 interactors.
IntActiO46108. 12 interactors.
MINTiMINT-4080713.
STRINGi7227.FBpp0082239.

Protein family/group databases

ESTHERidrome-lip3. Acidic_Lipase.

Proteomic databases

PaxDbiO46108.
PRIDEiO46108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082771; FBpp0082239; FBgn0023495.
GeneIDi41643.
KEGGidme:Dmel_CG8823.
UCSCiCG8823-RA. d. melanogaster.

Organism-specific databases

CTDi41643.
FlyBaseiFBgn0023495. Lip3.

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
InParanoidiO46108.
OMAiDWMCDVS.
OrthoDBiEOG091G09AX.
PhylomeDBiO46108.

Enzyme and pathway databases

ReactomeiR-DME-171052. LDL-mediated lipid transport.
R-DME-192456. Digestion of dietary lipid.

Miscellaneous databases

GenomeRNAii41643.
PROiO46108.

Gene expression databases

BgeeiFBgn0023495.
GenevisibleiO46108. DM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF04083. Abhydro_lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIP3_DROME
AccessioniPrimary (citable) accession number: O46108
Secondary accession number(s): Q4V3U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.