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Protein

alpha-1,2-Mannosidase

Gene

Edem1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: FlyBase
  • endoplasmic reticulum unfolded protein response Source: FlyBase
  • ER-associated ubiquitin-dependent protein catabolic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-901032. ER Quality Control Compartment (ERQC).

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Names & Taxonomyi

Protein namesi
Recommended name:
alpha-1,2-MannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:Edem1Imported
Synonyms:EG:86E4.2Imported
ORF Names:CG3810Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0023511. Edem1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 995966alpha-1,2-MannosidaseSequence analysisPRO_5004159257Add
BLAST

Proteomic databases

PaxDbiO46091.
PeptideAtlasiO46091.
PRIDEiO46091.

Expressioni

Gene expression databases

BgeeiO46091.
ExpressionAtlasiO46091. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0304832.

Structurei

3D structure databases

ProteinModelPortaliO46091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2429. Eukaryota.
ENOG410XS6F. LUCA.
OrthoDBiEOG7MWGWT.
PhylomeDBiO46091.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

O46091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQKPRNNGY PGTLICAVLL VLLSTGVSGQ KQYSKARKLE LREDVRRMFQ
60 70 80 90 100
HAYDGYLRHA SNYDELRPLT CDGHDTWGSY SLTLIDALDT LATMGNFTEF
110 120 130 140 150
RRAARLLEEK MDFDRDINVS VFETNIRIVG GLLSAHLLSK RAGVELEPGW
160 170 180 190 200
PCKGPLLRLA EDVARRLLPA FVTNTGMPYG TVNLRYGVPK GETSITCTAG
210 220 230 240 250
VGTFLIEFGT LSRLTGKTIY EDVAMKAVHA LWAYRSPIGL FGNHIDVQSG
260 270 280 290 300
RWTALDSGIG AGVDSLFEYL VKASVLLNRP ELLELFHEAR AAIDKYMRKE
310 320 330 340 350
DWYVWVGMNK GRVTLPVFQS LEAFWPGILS IIGDTEPALR TISRYIGVWK
360 370 380 390 400
KYGFLPEFYN IAAGEASPNR EVYPLRPELI ESAMYLYRAT GNEYLLEFGE
410 420 430 440 450
HMLETLEFSA KTKCGYATIR NVVTHEKENR MESFFLAETS KYLYLLFDEE
460 470 480 490 500
NFLHNDGSGG ELLSTEDDVC VVQAGAYIFN TEAHPMDMSA LHCCHAHNED
510 520 530 540 550
IYTSLDLQRF SPRAILERSK KRQVAVQEQW VPQCHPENNE FFNKEDESVQ
560 570 580 590 600
AQDSEKEQER EQSGTSTTMA VDIEVFDEFQ QPAGDLLVSN FEQIREEREL
610 620 630 640 650
NESLHRNVVA RNQLTVSDLD EFFAQRRESF ASASEALNYV KTFMGNYTMD
660 670 680 690 700
VAFIRGLQLY DTNMSSVLGT GAQKEYESRM RTLWQLYELQ QQYVANIRVI
710 720 730 740 750
QGLGLLTFPA DGDRIPSHLT EVLDSLDKSA HLEHMDLQDL ETRVSNTSSP
760 770 780 790 800
QLAHIREVIL KARNAYAIAM VNTSAMQEFA IRIYLSGTSE AGVRIHPLLE
810 820 830 840 850
DAELSEEARK RPLKLAEERA LFSYARRIVD FRKRMAETVD RLQTLMQDIP
860 870 880 890 900
PPKRKEATTD SQAADASTVY TQTKAQMAAP AQQPEPSQEE KQSTQIQKGK
910 920 930 940 950
LAENGSGLGE EESGCVWSQL VQTILRKTTV QRVKFDEAVL QENTRKALEK
960 970 980 990
YARKELPHHL FACTGRSTLR DSPIGTFIRK RCKLAITSPT NTTDL
Length:995
Mass (Da):112,675
Last modified:June 1, 1998 - v1
Checksum:iEAA06A73EB7B5DD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021086 Genomic DNA. Translation: CAA15933.1.

Genome annotation databases

UCSCiCG3810-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021086 Genomic DNA. Translation: CAA15933.1.

3D structure databases

ProteinModelPortaliO46091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0304832.

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Proteomic databases

PaxDbiO46091.
PeptideAtlasiO46091.
PRIDEiO46091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiCG3810-RB. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0023511. Edem1.

Phylogenomic databases

eggNOGiKOG2429. Eukaryota.
ENOG410XS6F. LUCA.
OrthoDBiEOG7MWGWT.
PhylomeDBiO46091.

Enzyme and pathway databases

ReactomeiR-DME-901032. ER Quality Control Compartment (ERQC).

Gene expression databases

BgeeiO46091.
ExpressionAtlasiO46091. differential.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequencing the distal X chromosome of Drosophila melanogaster."
    Ferraz C., Vidal S., Brun C., Bucheton A., Demaille J.G.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Benos P.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO46091_DROME
AccessioniPrimary (citable) accession number: O46091
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.