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O46084

- PGAM5_DROME

UniProt

O46084 - PGAM5_DROME

Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

    GO - Molecular functioni

    1. kinase binding Source: UniProtKB
    2. phosphoprotein phosphatase activity Source: UniProtKB
    3. protein binding Source: FlyBase
    4. protein serine/threonine kinase activator activity Source: FlyBase

    GO - Biological processi

    1. peptidyl-threonine dephosphorylation Source: FlyBase
    2. positive regulation of mitochondrial fission Source: FlyBase
    3. positive regulation of protein serine/threonine kinase activity Source: GOC
    4. protein dephosphorylation Source: UniProtKB
    5. regulation of mitochondrion organization Source: FlyBase
    6. response to anesthetic Source: FlyBase
    7. response to heat Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
    Short name:
    DPGAM5
    Alternative name(s):
    Phosphoglycerate mutase family member 5 homolog
    Gene namesi
    Name:Pgam5
    ORF Names:CG14816
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0023517. Pgam5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: FlyBase
    2. mitochondrial outer membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: FlyBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000288789Add
    BLAST

    Proteomic databases

    PaxDbiO46084.
    PRIDEiO46084.

    Expressioni

    Gene expression databases

    BgeeiO46084.

    Interactioni

    Subunit structurei

    Interacts with Pk92B/ASK1.1 Publication

    Protein-protein interaction databases

    BioGridi57689. 20 interactions.
    DIPiDIP-18549N.
    IntActiO46084. 17 interactions.
    MINTiMINT-928929.
    STRINGi7227.FBpp0070350.

    Structurei

    3D structure databases

    ProteinModelPortaliO46084.
    SMRiO46084. Positions 78-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71348.
    GeneTreeiENSGT00390000004796.
    InParanoidiO46084.
    KOiK15637.
    OMAiWLRMSLN.
    OrthoDBiEOG7966H1.
    PhylomeDBiO46084.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O46084-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKLTSFVCG TGAGLAAYYL QRLRDPQTVV QNSWTHSDKP VDPWALWDTN    50
    WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV 100
    GDSDDTHHLT ERGRKQAEFT GKRLCELGIK WDKVVASTMV RAQETSDIIL 150
    KQIDFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAGFR 200
    RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRININHASI 250
    TWLTISPSGN VSIKYLGDSG FMPAELLTNR IPRDVKNVV 289
    Length:289
    Mass (Da):33,166
    Last modified:June 1, 1998 - v1
    Checksum:i6DE63EE448170361
    GO

    Sequence cautioni

    The sequence AAL28156.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF45678.1.
    AL021106 Genomic DNA. Translation: CAA15939.1.
    AY060608 mRNA. Translation: AAL28156.2. Different initiation.
    PIRiT12682.
    RefSeqiNP_569951.1. NM_130595.2.
    UniGeneiDm.3943.

    Genome annotation databases

    EnsemblMetazoaiFBtr0070366; FBpp0070350; FBgn0023517.
    GeneIDi31143.
    KEGGidme:Dmel_CG14816.
    UCSCiCG14816-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF45678.1 .
    AL021106 Genomic DNA. Translation: CAA15939.1 .
    AY060608 mRNA. Translation: AAL28156.2 . Different initiation.
    PIRi T12682.
    RefSeqi NP_569951.1. NM_130595.2.
    UniGenei Dm.3943.

    3D structure databases

    ProteinModelPortali O46084.
    SMRi O46084. Positions 78-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 57689. 20 interactions.
    DIPi DIP-18549N.
    IntActi O46084. 17 interactions.
    MINTi MINT-928929.
    STRINGi 7227.FBpp0070350.

    Proteomic databases

    PaxDbi O46084.
    PRIDEi O46084.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0070366 ; FBpp0070350 ; FBgn0023517 .
    GeneIDi 31143.
    KEGGi dme:Dmel_CG14816.
    UCSCi CG14816-RA. d. melanogaster.

    Organism-specific databases

    CTDi 192111.
    FlyBasei FBgn0023517. Pgam5.

    Phylogenomic databases

    eggNOGi NOG71348.
    GeneTreei ENSGT00390000004796.
    InParanoidi O46084.
    KOi K15637.
    OMAi WLRMSLN.
    OrthoDBi EOG7966H1.
    PhylomeDBi O46084.

    Miscellaneous databases

    GenomeRNAii 31143.
    NextBioi 772127.

    Gene expression databases

    Bgeei O46084.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Oregon-R.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Head.
    5. "Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1."
      Takeda K., Komuro Y., Hayakawa T., Oguchi H., Ishida Y., Murakami S., Noguchi T., Kinoshita H., Sekine Y., Iemura S., Natsume T., Ichijo H.
      Proc. Natl. Acad. Sci. U.S.A. 106:12301-12305(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH PK92B.

    Entry informationi

    Entry nameiPGAM5_DROME
    AccessioniPrimary (citable) accession number: O46084
    Secondary accession number(s): Q7K2X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3