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Protein

Probable ATP-dependent RNA helicase kurz

Gene

kz

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi283 – 290ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • helicase activity Source: FlyBase
  • poly(A) RNA binding Source: GO_Central

GO - Biological processi

  • neurogenesis Source: FlyBase
  • RNA processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase kurz (EC:3.6.4.13)
Gene namesi
Name:kz
ORF Names:CG3228
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001330. kz.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550061 – 1192Probable ATP-dependent RNA helicase kurzAdd BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei529Phosphoserine1 Publication1
Modified residuei530Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO46072.
PRIDEiO46072.

PTM databases

iPTMnetiO46072.

Expressioni

Developmental stagei

Maternal protein detectable up to 6 hours of embryonic development.1 Publication

Gene expression databases

BgeeiFBgn0001330.
ExpressionAtlasiO46072. baseline.
GenevisibleiO46072. DM.

Interactioni

Protein-protein interaction databases

BioGridi57743. 2 interactors.
IntActiO46072. 5 interactors.
STRINGi7227.FBpp0070403.

Structurei

3D structure databases

ProteinModelPortaliO46072.
SMRiO46072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 436Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167
Domaini540 – 746Helicase C-terminalPROSITE-ProRule annotationAdd BLAST207

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi379 – 382DEAH box4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0926. Eukaryota.
COG1643. LUCA.
InParanoidiO46072.
KOiK14780.
OMAiPVDKKEP.
OrthoDBiEOG091G02IP.
PhylomeDBiO46072.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKVHNAKA RQNPQTIVDN SAVKKIQIDV DAVAGGNQVG YDEANALVLP
60 70 80 90 100
SEKRATKIKV DKVQHVKILS KKQRKHLQAI VDKKKKKEGR AQLLGDLAAV
110 120 130 140 150
QIPEEELQQY TSISQVQTVG LKRLPTLDEY LAKKKERQAQ VLAEKSSASG
160 170 180 190 200
LRVNAIKGSK RKLLVEEEEE LQAKRKNPNV ISVEEDDEDS SSSDEDDEEA
210 220 230 240 250
PAQSAPIAIP TPVSIAPPQI AVKPPIKKLK PEPNPPACIH QTVYVPVHRT
260 270 280 290 300
TEVQNARLRL PILAEEQQVM ETINENPIVI VAGETGSGKT TQLPQFLYEA
310 320 330 340 350
GYAQHKMIGV TEPRRVAAIA MSKRVAHEMN LPESEVSYLI RFEGNVTPAT
360 370 380 390 400
RIKFMTDGVL LKEIETDFLL SKYSVIILDE AHERSVYTDI LVGLLSRIVP
410 420 430 440 450
LRHKRGQPLK LIIMSATLRV SDFTENTRLF KIPPPLLKVE ARQFPVTIHF
460 470 480 490 500
QKRTPDDYVA EAYRKTLKIH NKLPEGGILI FVTGQQEVNQ LVRKLRRTFP
510 520 530 540 550
YHHAPTKDVA KNGKVSEEEK EETIDDAAST VEDPKELEFD MKRVIRNIRK
560 570 580 590 600
SKKKFLAQMA LPKINLDDYK LPGDDTEADM HEQPDEDDEQ EGLEEDNDDE
610 620 630 640 650
LGLEDESGMG SGQRQPLWVL PLYSLLSSEK QNRIFLPVPD GCRLCVVSTN
660 670 680 690 700
VAETSLTIPH IKYVVDCGRQ KTRLYDKLTG VSAFVVTYTS KASADQRAGR
710 720 730 740 750
AGRISAGHCY RLYSSAVYND CFEDFSQPDI QKKPVEDLML QMRCMGIDRV
760 770 780 790 800
VHFPFPSPPD QVQLQAAERR LIVLGALEVA KTENTDLPPA VTRLGHVISR
810 820 830 840 850
FPVAPRFGKM LALSHQQNLL PYTVCLVAAL SVQEVLIETG VQRDEDVAPG
860 870 880 890 900
ANRFHRKRQS WAASGNYQLL GDPMVLLRAV GAAEYAGSQG RLPEFCAANG
910 920 930 940 950
LRQKAMSEVR KLRVQLTNEI NLNVSDVELG VDPELKPPTD AQARFLRQIL
960 970 980 990 1000
LAGMGDRVAR KVPLADIADK EERRRLKYAY NCADMEEPAF LHVSSVLRQK
1010 1020 1030 1040 1050
APEWVIYQEA YELQNGDSTK MFIRGITAIE PEWLLLYVPL LCNIREVRED
1060 1070 1080 1090 1100
PAPRFDKTSG KIFCHVDATF GKSGWELPLG EVEMPLSEKA CCYFGMFLLD
1110 1120 1130 1140 1150
GEVCSRLADF RSKLKSTPAS VIKSWSSMNN KVLRFKRALI TKQIHNRQAL
1160 1170 1180 1190
IDQWNSDPHF LLEEYQNLLY DVALSELTPL WPPVDKKEPQ RQ
Length:1,192
Mass (Da):134,121
Last modified:June 1, 1998 - v1
Checksum:i569D4477D2EF8095
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64418 Genomic DNA. Translation: CAB55570.1.
AE014298 Genomic DNA. Translation: AAF45757.1.
AL009195 Genomic DNA. Translation: CAA15706.1.
PIRiT13424.
RefSeqiNP_001284815.1. NM_001297886.1.
NP_476591.1. NM_057243.4.
UniGeneiDm.33.

Genome annotation databases

EnsemblMetazoaiFBtr0070419; FBpp0070403; FBgn0001330.
FBtr0342769; FBpp0309621; FBgn0001330.
GeneIDi31205.
KEGGidme:Dmel_CG3228.
UCSCiCG3228-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64418 Genomic DNA. Translation: CAB55570.1.
AE014298 Genomic DNA. Translation: AAF45757.1.
AL009195 Genomic DNA. Translation: CAA15706.1.
PIRiT13424.
RefSeqiNP_001284815.1. NM_001297886.1.
NP_476591.1. NM_057243.4.
UniGeneiDm.33.

3D structure databases

ProteinModelPortaliO46072.
SMRiO46072.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57743. 2 interactors.
IntActiO46072. 5 interactors.
STRINGi7227.FBpp0070403.

PTM databases

iPTMnetiO46072.

Proteomic databases

PaxDbiO46072.
PRIDEiO46072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070419; FBpp0070403; FBgn0001330.
FBtr0342769; FBpp0309621; FBgn0001330.
GeneIDi31205.
KEGGidme:Dmel_CG3228.
UCSCiCG3228-RA. d. melanogaster.

Organism-specific databases

CTDi31205.
FlyBaseiFBgn0001330. kz.

Phylogenomic databases

eggNOGiKOG0926. Eukaryota.
COG1643. LUCA.
InParanoidiO46072.
KOiK14780.
OMAiPVDKKEP.
OrthoDBiEOG091G02IP.
PhylomeDBiO46072.

Enzyme and pathway databases

ReactomeiR-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSisls. fly.
GenomeRNAii31205.
PROiO46072.

Gene expression databases

BgeeiFBgn0001330.
ExpressionAtlasiO46072. baseline.
GenevisibleiO46072. DM.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKZ_DROME
AccessioniPrimary (citable) accession number: O46072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

'Kurz' means 'short' in German.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.