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Protein

Cytochrome P450 4ae1

Gene

Cyp4ae1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi443Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4ae1 (EC:1.14.-.-)
Alternative name(s):
CYPIVAE1
Gene namesi
Name:Cyp4ae1
Synonyms:CYP4E4
ORF Names:CG10755
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015036. Cyp4ae1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518301 – 496Cytochrome P450 4ae1Add BLAST496

Proteomic databases

PaxDbiO46054.
PRIDEiO46054.

Expressioni

Gene expression databases

BgeeiFBgn0015036.
GenevisibleiO46054. DM.

Interactioni

Protein-protein interaction databases

BioGridi57733. 7 interactors.
IntActiO46054. 4 interactors.
STRINGi7227.FBpp0070372.

Structurei

3D structure databases

ProteinModelPortaliO46054.
SMRiO46054.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiO46054.
KOiK15001.
OMAiNLHEKFA.
OrthoDBiEOG091G06KN.
PhylomeDBiO46054.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

O46054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVVLLVALL VTRLVASLFR LALKELRHPL QGVVPSVSRV PLLGAAWQMR
60 70 80 90 100
SFQPDNLHDK FAEYVKRFGR SFMGTVLGHV VMVTAEPRHI DALLQGQHQL
110 120 130 140 150
KKGTMYFALR GWLGDGLLLS RGKEWHTMRK IITPTFHFSI LEQFVEVFDR
160 170 180 190 200
QSSILVERLR TLSYGNEVVN IYPLVGLAAL DIITETAMGV NVDAQGADSE
210 220 230 240 250
VVHAVKDLTN ILATRFMRPH LLFPHLFRLC WPSGFRKQQA GVICLHEFTN
260 270 280 290 300
GIIEQRRRLL AREANQDKPT KPHALLDTLL RATVDGQPLT DKQIRDEVNT
310 320 330 340 350
FIFEGHDTTT SAVSFCLYLL SRHEAVQQKL FEELRMHYGQ DLFRGVILSD
360 370 380 390 400
FATLPYLSCV VKESLRLYPP IPAVARCLEK DLVIDEGYIP VGTNVVVLLW
410 420 430 440 450
QLLRDEAIFT DPLVFQPERH LGEEAPRLSP YSYIPFSAGP RNCIGQKFAL
460 470 480 490
LEMKTMVTKV IRHYQLLPMG ADVEPSIKIV LRSKSGVNVG LRPRLY
Length:496
Mass (Da):56,275
Last modified:June 1, 1998 - v1
Checksum:iBD0DB620F008EB68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319L → P in AAA80665 (PubMed:8676871).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45742.1.
AL009194 Genomic DNA. Translation: CAA15700.1.
AY058450 mRNA. Translation: AAL13679.1.
U34331 mRNA. Translation: AAA80665.1.
RefSeqiNP_525044.1. NM_080305.4.
UniGeneiDm.29.

Genome annotation databases

EnsemblMetazoaiFBtr0070388; FBpp0070372; FBgn0015036.
GeneIDi31193.
KEGGidme:Dmel_CG10755.

Similar proteinsi

Entry informationi

Entry nameiC4AE1_DROME
AccessioniPrimary (citable) accession number: O46054
Secondary accession number(s): Q24129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families