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Protein

Cytochrome P450 4ae1

Gene

Cyp4ae1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4ae1 (EC:1.14.-.-)
Alternative name(s):
CYPIVAE1
Gene namesi
Name:Cyp4ae1
Synonyms:CYP4E4
ORF Names:CG10755
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015036. Cyp4ae1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Cytochrome P450 4ae1PRO_0000051830Add
BLAST

Proteomic databases

PaxDbiO46054.
PRIDEiO46054.

Expressioni

Gene expression databases

BgeeiO46054.
GenevisibleiO46054. DM.

Interactioni

Protein-protein interaction databases

BioGridi57733. 7 interactions.
IntActiO46054. 4 interactions.
STRINGi7227.FBpp0070372.

Structurei

3D structure databases

ProteinModelPortaliO46054.
SMRiO46054. Positions 57-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiO46054.
KOiK15001.
OrthoDBiEOG7CNZFK.
PhylomeDBiO46054.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVVLLVALL VTRLVASLFR LALKELRHPL QGVVPSVSRV PLLGAAWQMR
60 70 80 90 100
SFQPDNLHDK FAEYVKRFGR SFMGTVLGHV VMVTAEPRHI DALLQGQHQL
110 120 130 140 150
KKGTMYFALR GWLGDGLLLS RGKEWHTMRK IITPTFHFSI LEQFVEVFDR
160 170 180 190 200
QSSILVERLR TLSYGNEVVN IYPLVGLAAL DIITETAMGV NVDAQGADSE
210 220 230 240 250
VVHAVKDLTN ILATRFMRPH LLFPHLFRLC WPSGFRKQQA GVICLHEFTN
260 270 280 290 300
GIIEQRRRLL AREANQDKPT KPHALLDTLL RATVDGQPLT DKQIRDEVNT
310 320 330 340 350
FIFEGHDTTT SAVSFCLYLL SRHEAVQQKL FEELRMHYGQ DLFRGVILSD
360 370 380 390 400
FATLPYLSCV VKESLRLYPP IPAVARCLEK DLVIDEGYIP VGTNVVVLLW
410 420 430 440 450
QLLRDEAIFT DPLVFQPERH LGEEAPRLSP YSYIPFSAGP RNCIGQKFAL
460 470 480 490
LEMKTMVTKV IRHYQLLPMG ADVEPSIKIV LRSKSGVNVG LRPRLY
Length:496
Mass (Da):56,275
Last modified:June 1, 1998 - v1
Checksum:iBD0DB620F008EB68
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191L → P in AAA80665 (PubMed:8676871).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45742.1.
AL009194 Genomic DNA. Translation: CAA15700.1.
AY058450 mRNA. Translation: AAL13679.1.
U34331 mRNA. Translation: AAA80665.1.
RefSeqiNP_525044.1. NM_080305.4.
UniGeneiDm.29.

Genome annotation databases

EnsemblMetazoaiFBtr0070388; FBpp0070372; FBgn0015036.
GeneIDi31193.
KEGGidme:Dmel_CG10755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45742.1.
AL009194 Genomic DNA. Translation: CAA15700.1.
AY058450 mRNA. Translation: AAL13679.1.
U34331 mRNA. Translation: AAA80665.1.
RefSeqiNP_525044.1. NM_080305.4.
UniGeneiDm.29.

3D structure databases

ProteinModelPortaliO46054.
SMRiO46054. Positions 57-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57733. 7 interactions.
IntActiO46054. 4 interactions.
STRINGi7227.FBpp0070372.

Proteomic databases

PaxDbiO46054.
PRIDEiO46054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070388; FBpp0070372; FBgn0015036.
GeneIDi31193.
KEGGidme:Dmel_CG10755.

Organism-specific databases

CTDi31193.
FlyBaseiFBgn0015036. Cyp4ae1.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiO46054.
KOiK15001.
OrthoDBiEOG7CNZFK.
PhylomeDBiO46054.

Miscellaneous databases

GenomeRNAii31193.
NextBioi772393.
PROiO46054.

Gene expression databases

BgeeiO46054.
GenevisibleiO46054. DM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Oregon-R.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 309-434.
    Strain: Haag-79.

Entry informationi

Entry nameiC4AE1_DROME
AccessioniPrimary (citable) accession number: O46054
Secondary accession number(s): Q24129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.