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Protein

Probable cytochrome P450 4d14

Gene

Cyp4d14

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Heme (covalent; via 1 link)By similarity1
Metal bindingi454Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 4d14 (EC:1.14.-.-)
Alternative name(s):
CYPIVD14
Gene namesi
Name:Cyp4d14
ORF Names:CG3540
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023541. Cyp4d14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518371 – 507Probable cytochrome P450 4d14Add BLAST507

Proteomic databases

PaxDbiO46051.
PRIDEiO46051.

Expressioni

Gene expression databases

BgeeiFBgn0023541.
GenevisibleiO46051. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0301778.

Structurei

3D structure databases

ProteinModelPortaliO46051.
SMRiO46051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiO46051.
KOiK15001.
OrthoDBiEOG091G06KN.
PhylomeDBiO46051.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLELFAILL ATALAWDYMR KRRHNKMYAE AGIRGPKSYP LVGNAPLLIN
60 70 80 90 100
ESPKTIFDMQ FRLIAEFGKN IKTQMLGESG FMTADSKMIE AIMSSQQTIQ
110 120 130 140 150
KNNLYSLLVN WLGDGLLISQ GKKWFRRRKI ITPAFHFKIL EDFVEVFDQQ
160 170 180 190 200
SATMVQKLYD RADGKTVINM FPVACLCAMD IIAETAMGVK INAQLQPQFT
210 220 230 240 250
YVQSVTTASA MLAERFMNPL QRLDFTMKLF YPKLLDKLND AVKNMHDFTN
260 270 280 290 300
SVITERRELL QKAIADGGDA DAALLNDVGQ KRRMALLDVL LKSTIDGAPL
310 320 330 340 350
SNDDIREEVD TFMFEGHDTT TSSIAFTCYL LARHPEVQAR VFQEVRDVIG
360 370 380 390 400
DDKSAPVTMK LLGELKYLEC VIKESLRLFP SVPIIGRYIS QDTVLDGKLI
410 420 430 440 450
PADSNVIILI YHAQRDPDYF PDPEKFIPDR FSMERKGEIS PFAYTPFSAG
460 470 480 490 500
PRNCIGQKFA MLEMKSTISK MVRHFELLPL GEEVQPVLNV ILRSTTGINC

GLKPRVY
Length:507
Mass (Da):57,481
Last modified:June 1, 1998 - v1
Checksum:i01D33A556CA969A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45740.1.
AL009194 Genomic DNA. Translation: CAA15696.1.
RefSeqiNP_652020.1. NM_143763.4.
UniGeneiDm.12710.

Genome annotation databases

EnsemblMetazoaiFBtr0070426; FBpp0070410; FBgn0023541.
GeneIDi45706.
KEGGidme:Dmel_CG3540.
UCSCiCG3540-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45740.1.
AL009194 Genomic DNA. Translation: CAA15696.1.
RefSeqiNP_652020.1. NM_143763.4.
UniGeneiDm.12710.

3D structure databases

ProteinModelPortaliO46051.
SMRiO46051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0301778.

Proteomic databases

PaxDbiO46051.
PRIDEiO46051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070426; FBpp0070410; FBgn0023541.
GeneIDi45706.
KEGGidme:Dmel_CG3540.
UCSCiCG3540-RA. d. melanogaster.

Organism-specific databases

CTDi45706.
FlyBaseiFBgn0023541. Cyp4d14.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
InParanoidiO46051.
KOiK15001.
OrthoDBiEOG091G06KN.
PhylomeDBiO46051.

Miscellaneous databases

GenomeRNAii45706.
PROiO46051.

Gene expression databases

BgeeiFBgn0023541.
GenevisibleiO46051. DM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC4D14_DROME
AccessioniPrimary (citable) accession number: O46051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.