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Protein

Poly(ADP-ribose) glycohydrolase

Gene

Parg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.1 Publication

Catalytic activityi

Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D-ribose.

GO - Molecular functioni

GO - Biological processi

  • Cajal body organization Source: FlyBase
  • carbohydrate metabolic process Source: UniProtKB
  • chromatin silencing Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • maintenance of protein location in nucleus Source: FlyBase
  • regulation of histone acetylation Source: FlyBase
  • regulation of RNA splicing Source: FlyBase
  • response to heat Source: FlyBase

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-DME-110362 POLB-Dependent Long Patch Base Excision Repair

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(ADP-ribose) glycohydrolase (EC:3.2.1.143)
Gene namesi
Name:Parg
ORF Names:CG2864
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023216 Parg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Progressive neurodegeneration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666071 – 723Poly(ADP-ribose) glycohydrolaseAdd BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei579Phosphoserine1 Publication1
Modified residuei582Phosphoserine1 Publication1
Modified residuei583Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO46043
PRIDEiO46043

PTM databases

iPTMnetiO46043

Expressioni

Gene expression databases

BgeeiFBgn0023216
GenevisibleiO46043 DM

Interactioni

Protein-protein interaction databases

BioGridi57851, 4 interactors
IntActiO46043, 1 interactor
STRINGi7227.FBpp0298281

Structurei

3D structure databases

ProteinModelPortaliO46043
SMRiO46043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2064 Eukaryota
ENOG410XT3Y LUCA
GeneTreeiENSGT00390000003652
InParanoidiO46043
KOiK07759
OMAiHVRLPCA
OrthoDBiEOG091G01FM
PhylomeDBiO46043

Family and domain databases

InterProiView protein in InterPro
IPR007724 Poly_GlycHdrlase
PANTHERiPTHR12837 PTHR12837, 1 hit
PfamiView protein in Pfam
PF05028 PARG_cat, 1 hit

Sequencei

Sequence statusi: Complete.

O46043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSPDGGIS EIETEEEPEN LANSLDDSWR GVSMEAIHRN RQPFELENLP
60 70 80 90 100
PVTAGNLHRV MYQLPIRETP PRPYKSPGKW DSEHVRLPCA PESKYPRENP
110 120 130 140 150
DGSTTIDFRW EMIERALLQP IKTCEELQAA IISYNTTYRD QWHFRALHQL
160 170 180 190 200
LDEELDESET RVFFEDLLPR IIRLALRLPD LIQSPVPLLK HHKNASLSLS
210 220 230 240 250
QQQISCLLAN AFLCTFPRRN TLKRKSEYST FPDINFNRLY QSTGPAVLEK
260 270 280 290 300
LKCIMHYFRR VCPTERDASN VPTGVVTFVR RSGLPEHLID WSQSAAPLGD
310 320 330 340 350
VPLHVDAEGT IEDEGIGLLQ VDFANKYLGG GVLGHGCVQE EIRFVICPEL
360 370 380 390 400
LVGKLFTECL RPFEALVMLG AERYSNYTGY AGSFEWSGNF EDSTPRDSSG
410 420 430 440 450
RRQTAIVAID ALHFAQSHHQ YREDLMEREL NKAYIGFVHW MVTPPPGVAT
460 470 480 490 500
GNWGCGAFGG DSYLKALLQL MVCAQLGRPL AYYTFGNVEF RDDFHEMWLL
510 520 530 540 550
FRNDGTTVQQ LWSILRSYSR LIKEKSSKEP RENKASKKKL YDFIKEELKK
560 570 580 590 600
VRDVPGEGAS AEAGSSRVAG LGEGKSETSA KSSPELNKQP ARPQITITQQ
610 620 630 640 650
STDLLPAQLS QDNSNSSEDQ ALLMLSDDEE ANAMMEAASL EAKSSVEISN
660 670 680 690 700
SSTTSKTSST ATKSMGSGGR QLSLLEMLDT HYEKGSASKR PRKSPNCSKA
710 720
EGSAKSRKEI DVTDKDEKDD IVD
Length:723
Mass (Da):81,109
Last modified:April 16, 2014 - v3
Checksum:i90A5BA59775D611C
GO

Sequence cautioni

The sequence AAC28734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079556 mRNA Translation: AAC28734.1 Different initiation.
AE014298 Genomic DNA Translation: AAF45886.2
AE014298 Genomic DNA Translation: AFH07225.1
Z98254 Genomic DNA Translation: CAB10913.1
AY051955 mRNA Translation: AAK93379.1
RefSeqiNP_001245511.1, NM_001258582.2
NP_477321.2, NM_057973.4
UniGeneiDm.2967

Genome annotation databases

EnsemblMetazoaiFBtr0307279; FBpp0298280; FBgn0023216
FBtr0307280; FBpp0298281; FBgn0023216
GeneIDi31329
KEGGidme:Dmel_CG2864

Similar proteinsi

Entry informationi

Entry nameiPARG_DROME
AccessioniPrimary (citable) accession number: O46043
Secondary accession number(s): M9NEU9, Q960N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: April 16, 2014
Last modified: February 28, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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