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Protein
Submitted name:

Cbl protein

Gene

Cbl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • ligase activity Source: FlyBase
  • phosphotyrosine binding Source: FlyBase
  • receptor tyrosine kinase binding Source: FlyBase
  • signal transducer activity Source: InterPro
  • ubiquitin-protein transferase activity Source: FlyBase
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • dorsal/ventral axis specification Source: FlyBase
  • dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBase
  • endocytosis Source: FlyBase
  • epidermal growth factor receptor signaling pathway Source: FlyBase
  • eye photoreceptor cell differentiation Source: FlyBase
  • germ-line cyst formation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • negative regulation of epidermal growth factor-activated receptor activity Source: FlyBase
  • negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
  • negative regulation of hormone biosynthetic process Source: FlyBase
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: FlyBase
  • proteolysis Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • regulation of carbohydrate metabolic process Source: FlyBase
  • regulation of cell death Source: FlyBase
  • regulation of cell proliferation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Enzyme and pathway databases

ReactomeiR-DME-1295596. Spry regulation of FGF signaling.
R-DME-1433559. Regulation of KIT signaling.
R-DME-182971. EGFR downregulation.
R-DME-5654726. Negative regulation of FGFR1 signaling.
R-DME-5654727. Negative regulation of FGFR2 signaling.
R-DME-5654732. Negative regulation of FGFR3 signaling.
R-DME-5654733. Negative regulation of FGFR4 signaling.
R-DME-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-DME-912631. Regulation of signaling by CBL.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proteinImported
Submitted name:
Cbl proto-oncogene ortholog, isoform AImported (EC:6.-.-.-Imported)
Submitted name:
LD46082pImported
Gene namesi
Name:CblImported
Synonyms:cblImported
ORF Names:CG7037Imported, Dmel_CG7037Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0020224. Cbl.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: FlyBase
  • cytoplasm Source: FlyBase
  • nucleus Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0020224.

Interactioni

GO - Molecular functioni

  • phosphotyrosine binding Source: FlyBase
  • receptor tyrosine kinase binding Source: FlyBase

Protein-protein interaction databases

MINTiMINT-312379.
STRINGi7227.FBpp0076342.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 339305Cbl-PTB (Cbl-type phosphotyrosine-binding)InterPro annotationAdd
BLAST
Domaini369 – 40941RING-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1785. Eukaryota.
ENOG410YDNH. LUCA.
GeneTreeiENSGT00390000011617.
OrthoDBiEOG091G0GPE.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O46034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRGSGTRV QSQPKIFPSL LSKLHGAISE ACVSQRLSTD KKTLEKTWKL
60 70 80 90 100
MDKVVKLCQQ PKMNLKNSPP FILDILPDTY QRLRLIYSKN EDQMHLLHAN
110 120 130 140 150
EHFNVFINNL MRKCKQAIKL FKEGKEKMFD ENSHYRRNLT KLSLVFSHML
160 170 180 190 200
SELKAIFPNG VFAGDQFRIT KADAADFWKS NFGNSTLVPW KIFRQELNKV
210 220 230 240 250
HPIISGLEAM ALKTTIDLTC NDFISNFEFD VFTRLFQPWV TLLRNWQILA
260 270 280 290 300
VTHPGYVAFL TYDEVKARLQ RYILKAGSYV FRLSCTRLGQ WAIGYVTAEG
310 320 330 340 350
EILQTIPQNK SLCQALLDGH REGFYLYPDG QAYNPDLSSA VQSPTEDHIT
360 370 380 390 400
VTQEQYELYC EMGSTFQLCK ICAENDKDIR IEPCGHLLCT PCLTSWQVDS
410 420 430 440
EGQGCPFCRA EIKGTEQIVV DAFDPRKQHN RNVTNGRQQQ QEEDDTEV
Length:448
Mass (Da):51,473
Last modified:June 1, 1998 - v1
Checksum:i26E3EA41820B64E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50417.1.
AY118593 mRNA. Translation: AAM49962.1.
AJ223175 mRNA. Translation: CAA11149.1.
RefSeqiNP_729382.1. NM_168276.2.
UniGeneiDm.2332.

Genome annotation databases

EnsemblMetazoaiFBtr0076614; FBpp0076341; FBgn0020224.
GeneIDi38961.
UCSCiCG7037-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50417.1.
AY118593 mRNA. Translation: AAM49962.1.
AJ223175 mRNA. Translation: CAA11149.1.
RefSeqiNP_729382.1. NM_168276.2.
UniGeneiDm.2332.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-312379.
STRINGi7227.FBpp0076342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076614; FBpp0076341; FBgn0020224.
GeneIDi38961.
UCSCiCG7037-RA. d. melanogaster.

Organism-specific databases

CTDi867.
FlyBaseiFBgn0020224. Cbl.

Phylogenomic databases

eggNOGiKOG1785. Eukaryota.
ENOG410YDNH. LUCA.
GeneTreeiENSGT00390000011617.
OrthoDBiEOG091G0GPE.

Enzyme and pathway databases

ReactomeiR-DME-1295596. Spry regulation of FGF signaling.
R-DME-1433559. Regulation of KIT signaling.
R-DME-182971. EGFR downregulation.
R-DME-5654726. Negative regulation of FGFR1 signaling.
R-DME-5654727. Negative regulation of FGFR2 signaling.
R-DME-5654732. Negative regulation of FGFR3 signaling.
R-DME-5654733. Negative regulation of FGFR4 signaling.
R-DME-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-DME-912631. Regulation of signaling by CBL.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii38961.

Gene expression databases

BgeeiFBgn0020224.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO46034_DROME
AccessioniPrimary (citable) accession number: O46034
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.