Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cbl protein

Gene

Cbl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • dorsal/ventral axis specification Source: FlyBase
  • dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBase
  • endocytosis Source: FlyBase
  • epidermal growth factor receptor signaling pathway Source: FlyBase
  • eye photoreceptor cell differentiation Source: FlyBase
  • germ-line cyst formation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • negative regulation of epidermal growth factor-activated receptor activity Source: FlyBase
  • negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
  • negative regulation of hormone biosynthetic process Source: FlyBase
  • proteolysis Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • regulation of carbohydrate metabolic process Source: FlyBase
  • regulation of cell death Source: FlyBase
  • regulation of cell proliferation Source: FlyBase
  • ubiquitin-dependent protein catabolic process Source: FlyBase

Keywordsi

Molecular functionLigaseImported
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-1295596 Spry regulation of FGF signaling
R-DME-1433559 Regulation of KIT signaling
R-DME-182971 EGFR downregulation
R-DME-5654726 Negative regulation of FGFR1 signaling
R-DME-5654727 Negative regulation of FGFR2 signaling
R-DME-5654732 Negative regulation of FGFR3 signaling
R-DME-5654733 Negative regulation of FGFR4 signaling
R-DME-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-912631 Regulation of signaling by CBL
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proteinImported
Submitted name:
Cbl proto-oncogene, isoform AImported (EC:6.-.-.-Imported)
Submitted name:
LD46082pImported
Gene namesi
Name:CblImported
Synonyms:anon-WO0118547.68Imported, CBLImported, cblImported, CG7043Imported, D-CblImported, D-cblImported, d-cblImported, D-Cbl LImported, D-CblLImported, D-cblLImported, D-cblSImported, DCblImported, DcblImported, dCblImported, Dmel\CG7037Imported, Dv-CblImported, Dv-cblImported, F165Imported, v-CblImported
ORF Names:CG7037Imported, Dmel_CG7037Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0020224 Cbl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0020224

Interactioni

GO - Molecular functioni

  • phosphotyrosine residue binding Source: FlyBase
  • receptor tyrosine kinase binding Source: FlyBase

Protein-protein interaction databases

IntActiO46034 4 interactors.

Structurei

3D structure databases

SMRiO46034
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 339Cbl-PTBInterPro annotationAdd BLAST305
Domaini369 – 409RING-typeInterPro annotationAdd BLAST41

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1785 Eukaryota
ENOG410YDNH LUCA
GeneTreeiENSGT00390000011617
OMAiWQHSDSQ
OrthoDBiEOG091G0GPE

Family and domain databases

CDDicd09920 SH2_Cbl-b_TKB, 1 hit
Gene3Di1.20.930.201 hit
3.30.40.101 hit
3.30.505.101 hit
InterProiView protein in InterPro
IPR024162 Adaptor_Cbl
IPR014741 Adaptor_Cbl_EF_hand-like
IPR036537 Adaptor_Cbl_N_dom_sf
IPR003153 Adaptor_Cbl_N_hlx
IPR014742 Adaptor_Cbl_SH2-like
IPR024159 Cbl_PTB
IPR011992 EF-hand-dom_pair
IPR036860 SH2_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23007 PTHR23007, 1 hit
PfamiView protein in Pfam
PF02262 Cbl_N, 1 hit
PF02761 Cbl_N2, 1 hit
PF02762 Cbl_N3, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47668 SSF47668, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51506 CBL_PTB, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

O46034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRGSGTRV QSQPKIFPSL LSKLHGAISE ACVSQRLSTD KKTLEKTWKL
60 70 80 90 100
MDKVVKLCQQ PKMNLKNSPP FILDILPDTY QRLRLIYSKN EDQMHLLHAN
110 120 130 140 150
EHFNVFINNL MRKCKQAIKL FKEGKEKMFD ENSHYRRNLT KLSLVFSHML
160 170 180 190 200
SELKAIFPNG VFAGDQFRIT KADAADFWKS NFGNSTLVPW KIFRQELNKV
210 220 230 240 250
HPIISGLEAM ALKTTIDLTC NDFISNFEFD VFTRLFQPWV TLLRNWQILA
260 270 280 290 300
VTHPGYVAFL TYDEVKARLQ RYILKAGSYV FRLSCTRLGQ WAIGYVTAEG
310 320 330 340 350
EILQTIPQNK SLCQALLDGH REGFYLYPDG QAYNPDLSSA VQSPTEDHIT
360 370 380 390 400
VTQEQYELYC EMGSTFQLCK ICAENDKDIR IEPCGHLLCT PCLTSWQVDS
410 420 430 440
EGQGCPFCRA EIKGTEQIVV DAFDPRKQHN RNVTNGRQQQ QEEDDTEV
Length:448
Mass (Da):51,473
Last modified:June 1, 1998 - v1
Checksum:i26E3EA41820B64E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50417.1
AY118593 mRNA Translation: AAM49962.1
AJ223175 mRNA Translation: CAA11149.1
RefSeqiNP_729382.1, NM_168276.2
UniGeneiDm.2332

Genome annotation databases

EnsemblMetazoaiFBtr0076614; FBpp0076341; FBgn0020224
GeneIDi38961
UCSCiCG7037-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiO46034_DROME
AccessioniPrimary (citable) accession number: O46034
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported