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Protein
Submitted name:

Cbl protein

Gene

Cbl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • ligase activity Source: FlyBase
  • phosphotyrosine residue binding Source: FlyBase
  • receptor tyrosine kinase binding Source: FlyBase
  • signal transducer activity Source: InterPro
  • ubiquitin-protein transferase activity Source: FlyBase
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • border follicle cell migration Source: FlyBase
  • dorsal/ventral axis specification Source: FlyBase
  • dorsal/ventral axis specification, ovarian follicular epithelium Source: FlyBase
  • endocytosis Source: FlyBase
  • epidermal growth factor receptor signaling pathway Source: FlyBase
  • eye photoreceptor cell differentiation Source: FlyBase
  • germ-line cyst formation Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • negative regulation of epidermal growth factor-activated receptor activity Source: FlyBase
  • negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
  • negative regulation of hormone biosynthetic process Source: FlyBase
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: FlyBase
  • proteolysis Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • regulation of carbohydrate metabolic process Source: FlyBase
  • regulation of cell death Source: FlyBase
  • regulation of cell proliferation Source: FlyBase

Keywordsi

Molecular functionLigaseImported
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-1295596. Spry regulation of FGF signaling.
R-DME-1433559. Regulation of KIT signaling.
R-DME-182971. EGFR downregulation.
R-DME-5654726. Negative regulation of FGFR1 signaling.
R-DME-5654727. Negative regulation of FGFR2 signaling.
R-DME-5654732. Negative regulation of FGFR3 signaling.
R-DME-5654733. Negative regulation of FGFR4 signaling.
R-DME-6807004. Negative regulation of MET activity.
R-DME-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-DME-912631. Regulation of signaling by CBL.

Names & Taxonomyi

Protein namesi
Submitted name:
Cbl proteinImported
Submitted name:
Cbl proto-oncogene, isoform AImported (EC:6.-.-.-Imported)
Submitted name:
LD46082pImported
Gene namesi
Name:CblImported
Synonyms:anon-WO0118547.68Imported, CBLImported, cblImported, D-CblImported, D-cblImported, d-cblImported, D-Cbl LImported, D-CblLImported, D-cblLImported, D-cblSImported, DCblImported, DcblImported, dCblImported, Dmel\CG7037Imported, Dv-CblImported, Dv-cblImported, F165Imported, v-CblImported
ORF Names:CG7037Imported, CG7043Imported, Dmel_CG7037Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0020224. Cbl.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: FlyBase
  • cytoplasm Source: FlyBase
  • nucleus Source: InterPro

Expressioni

Gene expression databases

BgeeiFBgn0020224.

Interactioni

GO - Molecular functioni

  • phosphotyrosine residue binding Source: FlyBase
  • receptor tyrosine kinase binding Source: FlyBase

Protein-protein interaction databases

MINTiMINT-312379.

Structurei

3D structure databases

SMRiO46034.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 339Cbl-PTB (Cbl-type phosphotyrosine-binding)InterPro annotationAdd BLAST305
Domaini369 – 409RING-typeInterPro annotationAdd BLAST41

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1785. Eukaryota.
ENOG410YDNH. LUCA.
GeneTreeiENSGT00390000011617.
OrthoDBiEOG091G0GPE.

Family and domain databases

CDDicd09920. SH2_Cbl-b_TKB. 1 hit.
Gene3Di1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiView protein in Pfam
PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O46034-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRGSGTRV QSQPKIFPSL LSKLHGAISE ACVSQRLSTD KKTLEKTWKL
60 70 80 90 100
MDKVVKLCQQ PKMNLKNSPP FILDILPDTY QRLRLIYSKN EDQMHLLHAN
110 120 130 140 150
EHFNVFINNL MRKCKQAIKL FKEGKEKMFD ENSHYRRNLT KLSLVFSHML
160 170 180 190 200
SELKAIFPNG VFAGDQFRIT KADAADFWKS NFGNSTLVPW KIFRQELNKV
210 220 230 240 250
HPIISGLEAM ALKTTIDLTC NDFISNFEFD VFTRLFQPWV TLLRNWQILA
260 270 280 290 300
VTHPGYVAFL TYDEVKARLQ RYILKAGSYV FRLSCTRLGQ WAIGYVTAEG
310 320 330 340 350
EILQTIPQNK SLCQALLDGH REGFYLYPDG QAYNPDLSSA VQSPTEDHIT
360 370 380 390 400
VTQEQYELYC EMGSTFQLCK ICAENDKDIR IEPCGHLLCT PCLTSWQVDS
410 420 430 440
EGQGCPFCRA EIKGTEQIVV DAFDPRKQHN RNVTNGRQQQ QEEDDTEV
Length:448
Mass (Da):51,473
Last modified:June 1, 1998 - v1
Checksum:i26E3EA41820B64E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50417.1.
AY118593 mRNA. Translation: AAM49962.1.
AJ223175 mRNA. Translation: CAA11149.1.
RefSeqiNP_729382.1. NM_168276.2.
UniGeneiDm.2332.

Genome annotation databases

EnsemblMetazoaiFBtr0076614; FBpp0076341; FBgn0020224.
GeneIDi38961.
UCSCiCG7037-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiO46034_DROME
AccessioniPrimary (citable) accession number: O46034
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported