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Protein

Nucleoporin SEH1

Gene

npp-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.1 Publication
As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

SignaLinkiO45933

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin SEH1By similarity
Short name:
CeSeh1By similarity
Alternative name(s):
GATOR complex protein SEH1Curated
Nuclear pore complex protein 181 Publication
SEC13-like proteinBy similarity
Gene namesi
Name:npp-18Imported
ORF Names:Y43F4B.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY43F4B.4 ; CE16629 ; WBGene00003804 ; npp-18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055431 – 363Nucleoporin SEH1Add BLAST363

Proteomic databases

EPDiO45933
PaxDbiO45933
PeptideAtlasiO45933
PRIDEiO45933

Expressioni

Gene expression databases

BgeeiWBGene00003804

Interactioni

Subunit structurei

Component of the nuclear pore complex (NPC). Probably part of the GATOR complex.By similarity

Protein-protein interaction databases

STRINGi6239.Y43F4B.4.2

Structurei

3D structure databases

ProteinModelPortaliO45933
SMRiO45933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 54WD 1Sequence analysisAdd BLAST40
Repeati60 – 101WD 2Sequence analysisAdd BLAST42
Repeati108 – 149WD 3Sequence analysisAdd BLAST42
Repeati158 – 206WD 4Sequence analysisAdd BLAST49
Repeati223 – 264WD 5Sequence analysisAdd BLAST42
Repeati287 – 326WD 6Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat SEC13 family.Sequence analysis

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2445 Eukaryota
ENOG410XRNW LUCA
GeneTreeiENSGT00550000074999
HOGENOMiHOG000216896
InParanoidiO45933
KOiK14299
OMAiIYEAPDI
OrthoDBiEOG091G09MA
PhylomeDBiO45933

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037597 Nucleoporin_Seh1
IPR037363 Sec13/Seh1_fam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11024 PTHR11024, 1 hit
PTHR11024:SF3 PTHR11024:SF3, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O45933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEDDSVKPF QTVGAHRDLI HCVSFDPHGR RMATCASDMT MAIWDRKPDG
60 70 80 90 100
NWRRSAHWKC HGGAVWRVIW AHPEFGQIVA TCSYDRTIVI WEEQIVRSEK
110 120 130 140 150
DLKQKESQWI RRTIISDNRS DVTDICFSPR HLGLMMASCN VLGTVRIYEA
160 170 180 190 200
PDIVDASRWN LIHELQAFHT RCGCVTWSLS RMHRPLIAVG SDEKKAENKK
210 220 230 240 250
RVVIYENIDG LRKWQRINSL VFDLPCPITD LKFSPISMVD SHQLAVASGD
260 270 280 290 300
VHVYNIKVAR SAILEEDGVE NPIQLADYNL IKVALLGDHR KAWRLRYNLM
310 320 330 340 350
GSVISSTSLD GTLRSWKSLF VNQWVKLSEM NVDDYVPSPE EVRAFISSKT
360
TERLPSQLEK TYF
Length:363
Mass (Da):41,726
Last modified:June 1, 1998 - v1
Checksum:iCE8E3FA6B3F09A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021481 Genomic DNA Translation: CAA16333.1
PIRiT26842
RefSeqiNP_499740.1, NM_067339.4
UniGeneiCel.6850

Genome annotation databases

EnsemblMetazoaiY43F4B.4; Y43F4B.4; WBGene00003804
GeneIDi176748
KEGGicel:CELE_Y43F4B.4
UCSCiY43F4B.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSEH1_CAEEL
AccessioniPrimary (citable) accession number: O45933
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health