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Protein

Nucleoporin SEH1

Gene

npp-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

SignaLinkiO45933.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin SEH1By similarity
Short name:
CeSeh1By similarity
Alternative name(s):
Nuclear pore complex protein 181 Publication
SEC13-like proteinBy similarity
Gene namesi
Name:npp-18Imported
ORF Names:Y43F4B.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY43F4B.4; CE16629; WBGene00003804; npp-18.

Subcellular locationi

  • Nucleusnuclear pore complex By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Nucleoporin SEH1PRO_0000405543Add
BLAST

Proteomic databases

EPDiO45933.
PaxDbiO45933.

Expressioni

Gene expression databases

BgeeiWBGene00003804.

Interactioni

Subunit structurei

Component of the nuclear pore complex (NPC).By similarity

Protein-protein interaction databases

STRINGi6239.Y43F4B.4.2.

Structurei

3D structure databases

ProteinModelPortaliO45933.
SMRiO45933. Positions 7-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 5440WD 1Sequence analysisAdd
BLAST
Repeati60 – 10142WD 2Sequence analysisAdd
BLAST
Repeati108 – 14942WD 3Sequence analysisAdd
BLAST
Repeati158 – 20649WD 4Sequence analysisAdd
BLAST
Repeati223 – 26442WD 5Sequence analysisAdd
BLAST
Repeati287 – 32640WD 6Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat SEC13 family.Sequence analysis
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2445. Eukaryota.
ENOG410XRNW. LUCA.
GeneTreeiENSGT00550000074999.
HOGENOMiHOG000216896.
InParanoidiO45933.
KOiK14299.
OMAiIYEAPDI.
OrthoDBiEOG091G09MA.
PhylomeDBiO45933.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEDDSVKPF QTVGAHRDLI HCVSFDPHGR RMATCASDMT MAIWDRKPDG
60 70 80 90 100
NWRRSAHWKC HGGAVWRVIW AHPEFGQIVA TCSYDRTIVI WEEQIVRSEK
110 120 130 140 150
DLKQKESQWI RRTIISDNRS DVTDICFSPR HLGLMMASCN VLGTVRIYEA
160 170 180 190 200
PDIVDASRWN LIHELQAFHT RCGCVTWSLS RMHRPLIAVG SDEKKAENKK
210 220 230 240 250
RVVIYENIDG LRKWQRINSL VFDLPCPITD LKFSPISMVD SHQLAVASGD
260 270 280 290 300
VHVYNIKVAR SAILEEDGVE NPIQLADYNL IKVALLGDHR KAWRLRYNLM
310 320 330 340 350
GSVISSTSLD GTLRSWKSLF VNQWVKLSEM NVDDYVPSPE EVRAFISSKT
360
TERLPSQLEK TYF
Length:363
Mass (Da):41,726
Last modified:June 1, 1998 - v1
Checksum:iCE8E3FA6B3F09A3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021481 Genomic DNA. Translation: CAA16333.1.
PIRiT26842.
RefSeqiNP_499740.1. NM_067339.4.
UniGeneiCel.6850.

Genome annotation databases

EnsemblMetazoaiY43F4B.4; Y43F4B.4; WBGene00003804.
GeneIDi176748.
KEGGicel:CELE_Y43F4B.4.
UCSCiY43F4B.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021481 Genomic DNA. Translation: CAA16333.1.
PIRiT26842.
RefSeqiNP_499740.1. NM_067339.4.
UniGeneiCel.6850.

3D structure databases

ProteinModelPortaliO45933.
SMRiO45933. Positions 7-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y43F4B.4.2.

Proteomic databases

EPDiO45933.
PaxDbiO45933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY43F4B.4; Y43F4B.4; WBGene00003804.
GeneIDi176748.
KEGGicel:CELE_Y43F4B.4.
UCSCiY43F4B.4. c. elegans.

Organism-specific databases

CTDi176748.
WormBaseiY43F4B.4; CE16629; WBGene00003804; npp-18.

Phylogenomic databases

eggNOGiKOG2445. Eukaryota.
ENOG410XRNW. LUCA.
GeneTreeiENSGT00550000074999.
HOGENOMiHOG000216896.
InParanoidiO45933.
KOiK14299.
OMAiIYEAPDI.
OrthoDBiEOG091G09MA.
PhylomeDBiO45933.

Enzyme and pathway databases

SignaLinkiO45933.

Miscellaneous databases

PROiO45933.

Gene expression databases

BgeeiWBGene00003804.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEH1_CAEEL
AccessioniPrimary (citable) accession number: O45933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.