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Protein

Probable trans-2-enoyl-CoA reductase 1, mitochondrial

Gene

W09H1.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421NADPBy similarity
Binding sitei338 – 3381NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1714NADPBy similarity
Nucleotide bindingi191 – 1933NADPBy similarity
Nucleotide bindingi255 – 2584NADPBy similarity
Nucleotide bindingi280 – 2823NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.3.1.38. 1045.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase 1, mitochondrial (EC:1.3.1.38)
Gene namesi
ORF Names:W09H1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiW09H1.5; CE16575; WBGene00012375; mecr-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1414MitochondrionSequence AnalysisAdd
BLAST
Chaini15 – 344330Probable trans-2-enoyl-CoA reductase 1, mitochondrialPRO_0000000892Add
BLAST

Proteomic databases

PaxDbiO45903.
PRIDEiO45903.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.W09H1.5.

Structurei

3D structure databases

ProteinModelPortaliO45903.
SMRiO45903. Positions 16-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
InParanoidiO45903.
KOiK07512.
OMAiCRAWGIN.
OrthoDBiEOG78M024.
PhylomeDBiO45903.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVLSLRSA LQRAASTRQL VYEGYRNPPE AIQLKTVTIA DKPSADQVLV
60 70 80 90 100
QWIAAPINPA DLNQIQGVYP VKPALPAVGG NEGFGKVISV GSNVSSIKVG
110 120 130 140 150
DHVIPDRSGL GTWRELGLHQ ENDLFPIDNT LSMEYAATFQ VNPPTAYRML
160 170 180 190 200
KDFIDLKKGD TVAQNGANSA VGKHVIQICR ILGIKTVNVV RSRDNLEELV
210 220 230 240 250
KELKDLGADE VITQEELYSR KKKFPGVKLA LNCVGGRSSL FLASLLDHGG
260 270 280 290 300
CMVTYGGMSK QPVDCPTGPL IFKDISLRGF WMSRWYDIQK SPEKRHEMYQ
310 320 330 340
ELAGWMKSGE IKKQEIVKNR LEDHAKALDT ALSKFDKKQF FVLE
Length:344
Mass (Da):38,195
Last modified:June 1, 1998 - v1
Checksum:iF1E47BB2C89D5268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82081 Genomic DNA. Translation: CAB04958.1.
PIRiT26323.
RefSeqiNP_496800.1. NM_064399.3.
UniGeneiCel.14175.

Genome annotation databases

EnsemblMetazoaiW09H1.5; W09H1.5; WBGene00012375.
GeneIDi174963.
KEGGicel:CELE_W09H1.5.
UCSCiW09H1.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82081 Genomic DNA. Translation: CAB04958.1.
PIRiT26323.
RefSeqiNP_496800.1. NM_064399.3.
UniGeneiCel.14175.

3D structure databases

ProteinModelPortaliO45903.
SMRiO45903. Positions 16-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W09H1.5.

Proteomic databases

PaxDbiO45903.
PRIDEiO45903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW09H1.5; W09H1.5; WBGene00012375.
GeneIDi174963.
KEGGicel:CELE_W09H1.5.
UCSCiW09H1.5. c. elegans.

Organism-specific databases

CTDi174963.
WormBaseiW09H1.5; CE16575; WBGene00012375; mecr-1.

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
InParanoidiO45903.
KOiK07512.
OMAiCRAWGIN.
OrthoDBiEOG78M024.
PhylomeDBiO45903.

Enzyme and pathway databases

BRENDAi1.3.1.38. 1045.

Miscellaneous databases

NextBioi886210.
PROiO45903.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMECR1_CAEEL
AccessioniPrimary (citable) accession number: O45903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 1998
Last modified: April 1, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.