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O45903

- MECR1_CAEEL

UniProt

O45903 - MECR1_CAEEL

Protein

Probable trans-2-enoyl-CoA reductase 1, mitochondrial

Gene

W09H1.5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei142 – 1421NADPBy similarity
    Binding sitei338 – 3381NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi168 – 1714NADPBy similarity
    Nucleotide bindingi191 – 1933NADPBy similarity
    Nucleotide bindingi255 – 2584NADPBy similarity
    Nucleotide bindingi280 – 2823NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable trans-2-enoyl-CoA reductase 1, mitochondrial (EC:1.3.1.38)
    Gene namesi
    ORF Names:W09H1.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiW09H1.5; CE16575; WBGene00012375; mecr-1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1414MitochondrionSequence AnalysisAdd
    BLAST
    Chaini15 – 344330Probable trans-2-enoyl-CoA reductase 1, mitochondrialPRO_0000000892Add
    BLAST

    Proteomic databases

    PaxDbiO45903.
    PRIDEiO45903.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi6239.W09H1.5.

    Structurei

    3D structure databases

    ProteinModelPortaliO45903.
    SMRiO45903. Positions 16-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    GeneTreeiENSGT00740000115589.
    HOGENOMiHOG000294683.
    InParanoidiO45903.
    KOiK07512.
    OMAiCSTLWRV.
    OrthoDBiEOG78M024.
    PhylomeDBiO45903.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O45903-1 [UniParc]FASTAAdd to Basket

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    MLKVLSLRSA LQRAASTRQL VYEGYRNPPE AIQLKTVTIA DKPSADQVLV    50
    QWIAAPINPA DLNQIQGVYP VKPALPAVGG NEGFGKVISV GSNVSSIKVG 100
    DHVIPDRSGL GTWRELGLHQ ENDLFPIDNT LSMEYAATFQ VNPPTAYRML 150
    KDFIDLKKGD TVAQNGANSA VGKHVIQICR ILGIKTVNVV RSRDNLEELV 200
    KELKDLGADE VITQEELYSR KKKFPGVKLA LNCVGGRSSL FLASLLDHGG 250
    CMVTYGGMSK QPVDCPTGPL IFKDISLRGF WMSRWYDIQK SPEKRHEMYQ 300
    ELAGWMKSGE IKKQEIVKNR LEDHAKALDT ALSKFDKKQF FVLE 344
    Length:344
    Mass (Da):38,195
    Last modified:June 1, 1998 - v1
    Checksum:iF1E47BB2C89D5268
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82081 Genomic DNA. Translation: CAB04958.1.
    PIRiT26323.
    RefSeqiNP_496800.1. NM_064399.3.
    UniGeneiCel.14175.

    Genome annotation databases

    EnsemblMetazoaiW09H1.5; W09H1.5; WBGene00012375.
    GeneIDi174963.
    KEGGicel:CELE_W09H1.5.
    UCSCiW09H1.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82081 Genomic DNA. Translation: CAB04958.1 .
    PIRi T26323.
    RefSeqi NP_496800.1. NM_064399.3.
    UniGenei Cel.14175.

    3D structure databases

    ProteinModelPortali O45903.
    SMRi O45903. Positions 16-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.W09H1.5.

    Proteomic databases

    PaxDbi O45903.
    PRIDEi O45903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai W09H1.5 ; W09H1.5 ; WBGene00012375 .
    GeneIDi 174963.
    KEGGi cel:CELE_W09H1.5.
    UCSCi W09H1.5. c. elegans.

    Organism-specific databases

    CTDi 174963.
    WormBasei W09H1.5 ; CE16575 ; WBGene00012375 ; mecr-1.

    Phylogenomic databases

    eggNOGi COG0604.
    GeneTreei ENSGT00740000115589.
    HOGENOMi HOG000294683.
    InParanoidi O45903.
    KOi K07512.
    OMAi CSTLWRV.
    OrthoDBi EOG78M024.
    PhylomeDBi O45903.

    Miscellaneous databases

    NextBioi 886210.
    PROi O45903.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMECR1_CAEEL
    AccessioniPrimary (citable) accession number: O45903
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3