O45903 (MECR1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable trans-2-enoyl-CoA reductase 1, mitochondrial
EC=1.3.1.38

Gene names

ORF Names:

W09H1.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype. Source: WormBase fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 14	14	Mitochondrion Potential
	Chain	15 – 344	330	Probable trans-2-enoyl-CoA reductase 1, mitochondrial		PRO_0000000892

Sequences

	Sequence		Length	Mass (Da)
	O45903 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F1E47BB2C89D5268	FASTA	344	38,195
	10 20 30 40 50 60 MLKVLSLRSA LQRAASTRQL VYEGYRNPPE AIQLKTVTIA DKPSADQVLV QWIAAPINPA 70 80 90 100 110 120 DLNQIQGVYP VKPALPAVGG NEGFGKVISV GSNVSSIKVG DHVIPDRSGL GTWRELGLHQ 130 140 150 160 170 180 ENDLFPIDNT LSMEYAATFQ VNPPTAYRML KDFIDLKKGD TVAQNGANSA VGKHVIQICR 190 200 210 220 230 240 ILGIKTVNVV RSRDNLEELV KELKDLGADE VITQEELYSR KKKFPGVKLA LNCVGGRSSL 250 260 270 280 290 300 FLASLLDHGG CMVTYGGMSK QPVDCPTGPL IFKDISLRGF WMSRWYDIQK SPEKRHEMYQ 310 320 330 340 ELAGWMKSGE IKKQEIVKNR LEDHAKALDT ALSKFDKKQF FVLE

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z82081 Genomic DNA. Translation: CAB04958.1.
PIR	T26323.
RefSeq	NP_496800.1. NM_064399.2.
UniGene	Cel.14175.
3D structure databases
ProteinModelPortal	O45903.
SMR	O45903. Positions 15-343.
ModBase	Search...
Protein-protein interaction databases
STRING	O45903.
Proteomic databases
PRIDE	O45903.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	W09H1.5; W09H1.5; W09H1.5.
GeneID	174963.
KEGG	cel:W09H1.5.
NMPDR	fig|6239.3.peg.7945.
UCSC	W09H1.5. c. elegans.
Organism-specific databases
CTD	174963.
WormBase	W09H1.5; CE16575; WBGene00012375; mecr-1.
Phylogenomic databases
eggNOG	meNOG05399.
GeneTree	EMGT00050000005681.
HOGENOM	HBG753318.
InParanoid	O45903.
OMA	RGFWMTR.
PhylomeDB	O45903.
Gene expression databases
ArrayExpress	O45903.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K07512.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
ProtoNet	Search...
Other
NextBio	886210.

Entry information

Entry name

MECR1_CAEEL

Accession

Primary (citable) accession number: O45903

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project