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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

W09H1.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton donorBy similarity1
Binding sitei142NADPBy similarity1
Binding sitei338NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 171NADPBy similarity4
Nucleotide bindingi191 – 193NADPBy similarity3
Nucleotide bindingi255 – 258NADPBy similarity4
Nucleotide bindingi280 – 282NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BRENDAi1.3.1.38. 1045.
ReactomeiR-CEL-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
ORF Names:W09H1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiW09H1.5; CE16575; WBGene00012375; mecr-1.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000000089215 – 344Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST330

Proteomic databases

EPDiO45903.
PaxDbiO45903.
PeptideAtlasiO45903.
PRIDEiO45903.

Expressioni

Gene expression databases

BgeeiWBGene00012375.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.W09H1.5.

Structurei

3D structure databases

ProteinModelPortaliO45903.
SMRiO45903.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0025. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294683.
InParanoidiO45903.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG091G0BAE.
PhylomeDBiO45903.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVLSLRSA LQRAASTRQL VYEGYRNPPE AIQLKTVTIA DKPSADQVLV
60 70 80 90 100
QWIAAPINPA DLNQIQGVYP VKPALPAVGG NEGFGKVISV GSNVSSIKVG
110 120 130 140 150
DHVIPDRSGL GTWRELGLHQ ENDLFPIDNT LSMEYAATFQ VNPPTAYRML
160 170 180 190 200
KDFIDLKKGD TVAQNGANSA VGKHVIQICR ILGIKTVNVV RSRDNLEELV
210 220 230 240 250
KELKDLGADE VITQEELYSR KKKFPGVKLA LNCVGGRSSL FLASLLDHGG
260 270 280 290 300
CMVTYGGMSK QPVDCPTGPL IFKDISLRGF WMSRWYDIQK SPEKRHEMYQ
310 320 330 340
ELAGWMKSGE IKKQEIVKNR LEDHAKALDT ALSKFDKKQF FVLE
Length:344
Mass (Da):38,195
Last modified:June 1, 1998 - v1
Checksum:iF1E47BB2C89D5268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82081 Genomic DNA. Translation: CAB04958.1.
PIRiT26323.
RefSeqiNP_496800.1. NM_064399.3.
UniGeneiCel.14175.

Genome annotation databases

EnsemblMetazoaiW09H1.5; W09H1.5; WBGene00012375.
GeneIDi174963.
KEGGicel:CELE_W09H1.5.
UCSCiW09H1.5. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMECR1_CAEEL
AccessioniPrimary (citable) accession number: O45903
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families