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O45903

- MECR1_CAEEL

UniProt

O45903 - MECR1_CAEEL

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Protein

Probable trans-2-enoyl-CoA reductase 1, mitochondrial

Gene

W09H1.5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421NADPBy similarity
Binding sitei338 – 3381NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1714NADPBy similarity
Nucleotide bindingi191 – 1933NADPBy similarity
Nucleotide bindingi255 – 2584NADPBy similarity
Nucleotide bindingi280 – 2823NADPBy similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase 1, mitochondrial (EC:1.3.1.38)
Gene namesi
ORF Names:W09H1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiW09H1.5; CE16575; WBGene00012375; mecr-1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1414MitochondrionSequence AnalysisAdd
BLAST
Chaini15 – 344330Probable trans-2-enoyl-CoA reductase 1, mitochondrialPRO_0000000892Add
BLAST

Proteomic databases

PaxDbiO45903.
PRIDEiO45903.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.W09H1.5.

Structurei

3D structure databases

ProteinModelPortaliO45903.
SMRiO45903. Positions 16-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
InParanoidiO45903.
KOiK07512.
OMAiCSTLWRV.
OrthoDBiEOG78M024.
PhylomeDBiO45903.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45903-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKVLSLRSA LQRAASTRQL VYEGYRNPPE AIQLKTVTIA DKPSADQVLV
60 70 80 90 100
QWIAAPINPA DLNQIQGVYP VKPALPAVGG NEGFGKVISV GSNVSSIKVG
110 120 130 140 150
DHVIPDRSGL GTWRELGLHQ ENDLFPIDNT LSMEYAATFQ VNPPTAYRML
160 170 180 190 200
KDFIDLKKGD TVAQNGANSA VGKHVIQICR ILGIKTVNVV RSRDNLEELV
210 220 230 240 250
KELKDLGADE VITQEELYSR KKKFPGVKLA LNCVGGRSSL FLASLLDHGG
260 270 280 290 300
CMVTYGGMSK QPVDCPTGPL IFKDISLRGF WMSRWYDIQK SPEKRHEMYQ
310 320 330 340
ELAGWMKSGE IKKQEIVKNR LEDHAKALDT ALSKFDKKQF FVLE
Length:344
Mass (Da):38,195
Last modified:June 1, 1998 - v1
Checksum:iF1E47BB2C89D5268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82081 Genomic DNA. Translation: CAB04958.1.
PIRiT26323.
RefSeqiNP_496800.1. NM_064399.3.
UniGeneiCel.14175.

Genome annotation databases

EnsemblMetazoaiW09H1.5; W09H1.5; WBGene00012375.
GeneIDi174963.
KEGGicel:CELE_W09H1.5.
UCSCiW09H1.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82081 Genomic DNA. Translation: CAB04958.1 .
PIRi T26323.
RefSeqi NP_496800.1. NM_064399.3.
UniGenei Cel.14175.

3D structure databases

ProteinModelPortali O45903.
SMRi O45903. Positions 16-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.W09H1.5.

Proteomic databases

PaxDbi O45903.
PRIDEi O45903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai W09H1.5 ; W09H1.5 ; WBGene00012375 .
GeneIDi 174963.
KEGGi cel:CELE_W09H1.5.
UCSCi W09H1.5. c. elegans.

Organism-specific databases

CTDi 174963.
WormBasei W09H1.5 ; CE16575 ; WBGene00012375 ; mecr-1.

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00740000115589.
HOGENOMi HOG000294683.
InParanoidi O45903.
KOi K07512.
OMAi CSTLWRV.
OrthoDBi EOG78M024.
PhylomeDBi O45903.

Miscellaneous databases

NextBioi 886210.
PROi O45903.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMECR1_CAEEL
AccessioniPrimary (citable) accession number: O45903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3