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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-33

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-33Imported
ORF Names:CELE_W06D12.5Imported, W06D12.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiW06D12.5; CE51299; WBGene00006685; twk-33.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei404 – 423HelicalSequence analysisAdd BLAST20
Transmembranei435 – 454HelicalSequence analysisAdd BLAST20
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO45894.

Expressioni

Gene expression databases

BgeeiWBGene00006685.

Interactioni

Protein-protein interaction databases

STRINGi6239.W06D12.5.

Structurei

3D structure databases

ProteinModelPortaliO45894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 368Ion_trans_2InterPro annotationAdd BLAST69
Domaini409 – 483Ion_trans_2InterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili243 – 270Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000017600.
InParanoidiO45894.
KOiK05323.
OrthoDBiEOG091G05MP.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

O45894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEQQNNYY PRGNVPRHSA VLEEIHEEEQ DSIPEEDETN LEKPSHSEND
60 70 80 90 100
FKRKNAIRSE ETPEISPEIQ RIEDPLASSD EEENEKPFAR SISVSNADLE
110 120 130 140 150
ERHRLDSIPE NDRSQQSRYT RHSSIDKGIL KPQNNSEDVV EKYYERNNYT
160 170 180 190 200
VTGRDRPDFY NKLPGRLQHR LSVHTDAASR FSSPGAMGEP VVPTLRRFDK
210 220 230 240 250
SMYWFAFHRK QIGFRHFSVV ILVLLYTLLG AVMFWTVESR HEKAKTLDHV
260 270 280 290 300
NNLEHLLDRL AENITESVNN INTTTTEEEM KVYIREAYIE LMKLEGQYKG
310 320 330 340 350
STYYKLEADD NWKWTFESAF FFSMNVYTTT GYGSIAPEST LGQVLVCVYG
360 370 380 390 400
FIFVPVTLVV LRDLGQFFLV HLTKLYAHGI QKFRELNGNK HVDEDEIISL
410 420 430 440 450
PIKACLLLLA SYLGACTIFI YFYDELSGPE PGTGMDMFLC FYFSFISLST
460 470 480 490 500
IGLGDIMPNN ATFAPIISII FFFGMAVTKV VNRNTFIAVE NGIFGAFTLV
510 520 530 540 550
ENKLDAIVTR SSASVKPEDR PSTPKVQRAL SVDAGSEVQD ETPNEILNNL
560 570 580 590 600
TVRSIATFMK SNADIYGGGF GRVQLRRGDL IHSDSQNQMT VNSMSQLRHR
610
TASQSQPNQA TGGNNNV
Length:617
Mass (Da):70,122
Last modified:May 11, 2016 - v2
Checksum:iCD9749747F078D69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB04926.2.
PIRiT26232.
RefSeqiNP_001309463.1. NM_001322605.1.

Genome annotation databases

EnsemblMetazoaiW06D12.5; W06D12.5; WBGene00006685.
GeneIDi180161.
KEGGicel:CELE_W06D12.5.
UCSCiW06D12.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB04926.2.
PIRiT26232.
RefSeqiNP_001309463.1. NM_001322605.1.

3D structure databases

ProteinModelPortaliO45894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.W06D12.5.

Proteomic databases

PaxDbiO45894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW06D12.5; W06D12.5; WBGene00006685.
GeneIDi180161.
KEGGicel:CELE_W06D12.5.
UCSCiW06D12.5. c. elegans.

Organism-specific databases

CTDi180161.
WormBaseiW06D12.5; CE51299; WBGene00006685; twk-33.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000017600.
InParanoidiO45894.
KOiK05323.
OrthoDBiEOG091G05MP.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Gene expression databases

BgeeiWBGene00006685.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Entry informationi

Entry nameiO45894_CAEEL
AccessioniPrimary (citable) accession number: O45894
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: May 11, 2016
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.