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Protein

Transporter

Gene

snf-12

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • positive regulation of antifungal peptide production Source: WormBase
  • transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-CEL-352230. Amino acid transport across the plasma membrane.
R-CEL-442660. Na+/Cl- dependent neurotransmitter transporters.
R-CEL-888593. Reuptake of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:snf-12Imported
ORF Names:CELE_T25B6.7Imported, T25B6.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT25B6.7; CE29353; WBGene00004911; snf-12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei166 – 18419HelicalSequence analysisAdd
BLAST
Transmembranei196 – 21722HelicalSequence analysisAdd
BLAST
Transmembranei238 – 26629HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Transmembranei445 – 47026HelicalSequence analysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence analysisAdd
BLAST
Transmembranei548 – 57528HelicalSequence analysisAdd
BLAST
Transmembranei587 – 60822HelicalSequence analysisAdd
BLAST
Transmembranei629 – 65931HelicalSequence analysisAdd
BLAST
Transmembranei679 – 69820HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: WormBase
  • endocytic vesicle Source: WormBase
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO45813.
PRIDEiO45813.

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.T25B6.7.

Structurei

3D structure databases

ProteinModelPortaliO45813.
SMRiO45813. Positions 155-721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3660. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000015931.
InParanoidiO45813.
OMAiCHADETE.
OrthoDBiEOG7G7KST.
PhylomeDBiO45813.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 3 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGEWKSALR LQIEALAKRN ELHRKSSVDE IKKRTVDMDK RIVKLRELVG
60 70 80 90 100
SSANDAALFY LECVCHADET ERLLNRGSSV GKEKKWKKVK RKTSSSVAPP
110 120 130 140 150
LSRTISSLPG VSSPDVIQTI DVSALEDQTP QRPHWWDQFQ LYRRTDLLRF
160 170 180 190 200
SKQNDRRELW RTQKDFFLSC LGFMVGVGHT MRFPAKVYQH GGGVFFIPYL
210 220 230 240 250
FSLIFFGLPL VFLHLSLGQY TGQAANTAFQ RLMPIGSGVG WALVVIAIPV
260 270 280 290 300
AVYYNIIVAW AIHYFFQSAK GLLLGDELPW ETCRDEWQLD NRCCNLHNLH
310 320 330 340 350
SCFNSTNSIT APEAFFHSEV LSLSTFGDFA LGPLQSHLVL SLAAAWLLVF
360 370 380 390 400
FGVFKGLGSI AQTMNVTATV PYLLLSILLL RGISLPGANK GLTFLFTVDS
410 420 430 440 450
TKLWKWQIWK SAAEQVFYEL GIDAGPLISM AAFSRYRNNI YRDSVLLVIM
460 470 480 490 500
DALTSCLSGM VIFSFVGFIA SESNSNVNDV LKHDPLYLSF TVYPGVTSFM
510 520 530 540 550
YWGGLWATLF FGMLVLAAID AEFAWLEMIA SAFMNHFSMK NKAVENRLLA
560 570 580 590 600
FLCLAGFFLG LPLCAQGGIF VFHAIENLNA NWNSFSLALL SVAIVCYVYG
610 620 630 640 650
IDNYLTDISA MLRVPRIQIS KATRLKEKLI YFFGPGGIYI KFSLCFICPV
660 670 680 690 700
ILTVLLVASV LGYQRISFAG RPIPIDYEIV AWIVMIGPLL VVPLVAFMQI
710 720 730 740 750
RQIRNEGKLL KSLFDTSEWR ESQDDSLEPK DLYMRQSGKF ESPPNRRRTP
760 770 780 790 800
TIFTHRENTY MYIDSRGPTV RSRVFPLGAS LDPYGWKAGR LRDRQQQIEE
810 820 830 840 850
TASNYSEEDS ATTNSFMAST VKHNDDMELT LFGSPPAILG DDEKIMTTRF
860 870 880 890 900
SESMPVNYKC RNVEVPRIPN KLPQNMERMA RKTRKKRSSP SASDPPVPTS
910 920 930 940 950
PLPPPPKLQH CRSEPPMMNS KESHSPEIIT PGDDSPSISN SSDDSSDDCF
960 970 980 990 1000
RRATVIRRKT SDDDAFTHFS TATAESISIT PLDFPRQRSL SSVAIYDQEQ
1010 1020
KNGRSKVLSQ LKRPKPIDMP PK
Length:1,022
Mass (Da):115,128
Last modified:December 1, 2001 - v2
Checksum:i55371B2C03865273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD65393.1.
PIRiT28905.
RefSeqiNP_509527.1. NM_077126.1.
UniGeneiCel.5619.

Genome annotation databases

EnsemblMetazoaiT25B6.7; T25B6.7; WBGene00004911.
GeneIDi181143.
KEGGicel:CELE_T25B6.7.
UCSCiT25B6.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD65393.1.
PIRiT28905.
RefSeqiNP_509527.1. NM_077126.1.
UniGeneiCel.5619.

3D structure databases

ProteinModelPortaliO45813.
SMRiO45813. Positions 155-721.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T25B6.7.

Proteomic databases

PaxDbiO45813.
PRIDEiO45813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT25B6.7; T25B6.7; WBGene00004911.
GeneIDi181143.
KEGGicel:CELE_T25B6.7.
UCSCiT25B6.7. c. elegans.

Organism-specific databases

CTDi181143.
WormBaseiT25B6.7; CE29353; WBGene00004911; snf-12.

Phylogenomic databases

eggNOGiKOG3660. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000015931.
InParanoidiO45813.
OMAiCHADETE.
OrthoDBiEOG7G7KST.
PhylomeDBiO45813.

Enzyme and pathway databases

ReactomeiR-CEL-352230. Amino acid transport across the plasma membrane.
R-CEL-442660. Na+/Cl- dependent neurotransmitter transporters.
R-CEL-888593. Reuptake of GABA.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 3 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO45813_CAEEL
AccessioniPrimary (citable) accession number: O45813
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.