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Protein
Submitted name:

CathePsin L family

Gene

cpl-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-1442490. Collagen degradation.
R-CEL-1474228. Degradation of the extracellular matrix.
R-CEL-2132295. MHC class II antigen presentation.
R-CEL-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiC01.141.

Names & Taxonomyi

Protein namesi
Submitted name:
CathePsin L familyImported
Gene namesi
Name:cpl-1Imported
ORF Names:CELE_T03E6.7Imported, T03E6.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT03E6.7a; CE16333; WBGene00000776; cpl-1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • lysosome Source: GO_Central
  • vesicle lumen Source: WormBase
  • yolk granule Source: WormBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_500539991219 – 337UniRule annotationAdd BLAST319

Proteomic databases

EPDiO45734.
PaxDbiO45734.
PeptideAtlasiO45734.

Expressioni

Gene expression databases

BgeeiWBGene00000776.
ExpressionAtlasiO45734. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lit-1Q9U9Y82EBI-315958,EBI-318513

Protein-protein interaction databases

DIPiDIP-26616N.
IntActiO45734. 8 interactors.
MINTiMINT-211563.
STRINGi6239.T03E6.7.1.

Structurei

3D structure databases

ProteinModelPortaliO45734.
SMRiO45734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 91Inhibitor_I29InterPro annotationAdd BLAST60
Domaini120 – 336Pept_C1InterPro annotationAdd BLAST217

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
InParanoidiO45734.
KOiK01365.
OMAiEMGLNHI.
OrthoDBiEOG091G0AKT.
PhylomeDBiO45734.

Family and domain databases

InterProiView protein in InterPro
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

O45734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRFILLALV AAVVAVNSAK LSRQIESAIE KWDDYKEDFD KEYSESEEQT
60 70 80 90 100
YMEAFVKNMI HIENHNRDHR LGRKTFEMGL NHIADLPFSQ YRKLNGYRRL
110 120 130 140 150
FGDSRIKNSS SFLAPFNVQV PDEVDWRDTH LVTDVKNQGM CGSCWAFSAT
160 170 180 190 200
GALEGQHARK LGQLVSLSEQ NLVDCSTKYG NHGCNGGLMD QAFEYIRDNH
210 220 230 240 250
GVDTEESYPY KGRDMKCHFN KKTVGADDKG YVDTPEGDEE QLKIAVATQG
260 270 280 290 300
PISIAIDAGH RSFQLYKKGV YYDEECSSEE LDHGVLLVGY GTDPEHGDYW
310 320 330
IVKNSWGAGW GEKGYIRIAR NRNNHCGVAT KASYPLV
Length:337
Mass (Da):38,117
Last modified:June 1, 1998 - v1
Checksum:iF5754DED0745EE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07275.1.
PIRiT24387.
RefSeqiNP_001256718.1. NM_001269789.1.
UniGeneiCel.17971.

Genome annotation databases

EnsemblMetazoaiT03E6.7a; T03E6.7a; WBGene00000776.
GeneIDi180111.
KEGGicel:CELE_T03E6.7.
UCSCiT03E6.7.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiO45734_CAEEL
AccessioniPrimary (citable) accession number: O45734
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported