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Protein
Submitted name:

CathePsin L family

Gene

cpl-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-1442490. Collagen degradation.
R-CEL-1474228. Degradation of the extracellular matrix.
R-CEL-1679131. Trafficking and processing of endosomal TLR.
R-CEL-2132295. MHC class II antigen presentation.

Protein family/group databases

MEROPSiC01.141.

Names & Taxonomyi

Protein namesi
Submitted name:
CathePsin L familyImported
Gene namesi
Name:cpl-1Imported
ORF Names:CELE_T03E6.7Imported, T03E6.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT03E6.7a; CE16333; WBGene00000776; cpl-1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • lysosome Source: GO_Central
  • vesicle lumen Source: WormBase
  • yolk granule Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818UniRule annotationAdd
BLAST
Chaini19 – 337319UniRule annotationPRO_5005399912Add
BLAST

Proteomic databases

EPDiO45734.
PaxDbiO45734.

Expressioni

Gene expression databases

BgeeiWBGene00000776.
ExpressionAtlasiO45734. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-26616N.
IntActiO45734. 8 interactions.
MINTiMINT-211563.
STRINGi6239.T03E6.7.1.

Structurei

3D structure databases

ProteinModelPortaliO45734.
SMRiO45734. Positions 31-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 9160Inhibitor_I29InterPro annotationAdd
BLAST
Domaini120 – 336217Pept_C1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
InParanoidiO45734.
KOiK01365.
OMAiDEVDWRD.
OrthoDBiEOG091G0AKT.
PhylomeDBiO45734.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRFILLALV AAVVAVNSAK LSRQIESAIE KWDDYKEDFD KEYSESEEQT
60 70 80 90 100
YMEAFVKNMI HIENHNRDHR LGRKTFEMGL NHIADLPFSQ YRKLNGYRRL
110 120 130 140 150
FGDSRIKNSS SFLAPFNVQV PDEVDWRDTH LVTDVKNQGM CGSCWAFSAT
160 170 180 190 200
GALEGQHARK LGQLVSLSEQ NLVDCSTKYG NHGCNGGLMD QAFEYIRDNH
210 220 230 240 250
GVDTEESYPY KGRDMKCHFN KKTVGADDKG YVDTPEGDEE QLKIAVATQG
260 270 280 290 300
PISIAIDAGH RSFQLYKKGV YYDEECSSEE LDHGVLLVGY GTDPEHGDYW
310 320 330
IVKNSWGAGW GEKGYIRIAR NRNNHCGVAT KASYPLV
Length:337
Mass (Da):38,117
Last modified:June 1, 1998 - v1
Checksum:iF5754DED0745EE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07275.1.
PIRiT24387.
RefSeqiNP_001256718.1. NM_001269789.1.
UniGeneiCel.17971.

Genome annotation databases

EnsemblMetazoaiT03E6.7a; T03E6.7a; WBGene00000776.
GeneIDi180111.
KEGGicel:CELE_T03E6.7.
UCSCiT03E6.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07275.1.
PIRiT24387.
RefSeqiNP_001256718.1. NM_001269789.1.
UniGeneiCel.17971.

3D structure databases

ProteinModelPortaliO45734.
SMRiO45734. Positions 31-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26616N.
IntActiO45734. 8 interactions.
MINTiMINT-211563.
STRINGi6239.T03E6.7.1.

Protein family/group databases

MEROPSiC01.141.

Proteomic databases

EPDiO45734.
PaxDbiO45734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT03E6.7a; T03E6.7a; WBGene00000776.
GeneIDi180111.
KEGGicel:CELE_T03E6.7.
UCSCiT03E6.7.1. c. elegans.

Organism-specific databases

CTDi180111.
WormBaseiT03E6.7a; CE16333; WBGene00000776; cpl-1.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
InParanoidiO45734.
KOiK01365.
OMAiDEVDWRD.
OrthoDBiEOG091G0AKT.
PhylomeDBiO45734.

Enzyme and pathway databases

ReactomeiR-CEL-1442490. Collagen degradation.
R-CEL-1474228. Degradation of the extracellular matrix.
R-CEL-1679131. Trafficking and processing of endosomal TLR.
R-CEL-2132295. MHC class II antigen presentation.

Gene expression databases

BgeeiWBGene00000776.
ExpressionAtlasiO45734. baseline.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO45734_CAEEL
AccessioniPrimary (citable) accession number: O45734
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.