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Protein
Submitted name:

CathePsin L family

Gene

cpl-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-1442490 Collagen degradation
R-CEL-1474228 Degradation of the extracellular matrix
R-CEL-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiC01.141

Names & Taxonomyi

Protein namesi
Submitted name:
CathePsin L familyImported
Gene namesi
Name:cpl-1Imported
ORF Names:CELE_T03E6.7Imported, T03E6.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT03E6.7a ; CE16333 ; WBGene00000776 ; cpl-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_500539991219 – 337UniRule annotationAdd BLAST319

Proteomic databases

EPDiO45734
PaxDbiO45734
PeptideAtlasiO45734

Expressioni

Gene expression databases

BgeeiWBGene00000776
ExpressionAtlasiO45734 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-26616N
IntActiO45734, 8 interactors
MINTiO45734
STRINGi6239.T03E6.7.1

Structurei

3D structure databases

ProteinModelPortaliO45734
SMRiO45734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 91Inhibitor_I29InterPro annotationAdd BLAST60
Domaini120 – 336Pept_C1InterPro annotationAdd BLAST217

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140823
HOGENOMiHOG000230774
InParanoidiO45734
KOiK01365
OMAiEMGLNHI
OrthoDBiEOG091G0AKT
PhylomeDBiO45734

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

O45734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRFILLALV AAVVAVNSAK LSRQIESAIE KWDDYKEDFD KEYSESEEQT
60 70 80 90 100
YMEAFVKNMI HIENHNRDHR LGRKTFEMGL NHIADLPFSQ YRKLNGYRRL
110 120 130 140 150
FGDSRIKNSS SFLAPFNVQV PDEVDWRDTH LVTDVKNQGM CGSCWAFSAT
160 170 180 190 200
GALEGQHARK LGQLVSLSEQ NLVDCSTKYG NHGCNGGLMD QAFEYIRDNH
210 220 230 240 250
GVDTEESYPY KGRDMKCHFN KKTVGADDKG YVDTPEGDEE QLKIAVATQG
260 270 280 290 300
PISIAIDAGH RSFQLYKKGV YYDEECSSEE LDHGVLLVGY GTDPEHGDYW
310 320 330
IVKNSWGAGW GEKGYIRIAR NRNNHCGVAT KASYPLV
Length:337
Mass (Da):38,117
Last modified:June 1, 1998 - v1
Checksum:iF5754DED0745EE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB07275.1
PIRiT24387
RefSeqiNP_001256718.1, NM_001269789.1
UniGeneiCel.17971

Genome annotation databases

EnsemblMetazoaiT03E6.7a; T03E6.7a; WBGene00000776
GeneIDi180111
KEGGicel:CELE_T03E6.7
UCSCiT03E6.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO45734_CAEEL
AccessioniPrimary (citable) accession number: O45734
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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