Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 2

Gene

sodh-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi157Zinc 1; catalyticBy similarity1
Binding sitei205NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 187NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Alternative name(s):
Sorbitol dehydrogenase family protein 2
Gene namesi
Name:sodh-2
ORF Names:K12G11.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK12G11.4 ; CE12214 ; WBGene00010791 ; sodh-2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606941 – 351Alcohol dehydrogenase 2Add BLAST351

Proteomic databases

PaxDbiO45687
PeptideAtlasiO45687
PRIDEiO45687

Expressioni

Gene expression databases

BgeeiWBGene00010791

Interactioni

Subunit structurei

Homotetramer.Curated

Protein-protein interaction databases

IntActiO45687, 1 interactor
STRINGi6239.K12G11.4

Structurei

3D structure databases

ProteinModelPortaliO45687
SMRiO45687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0023 Eukaryota
COG1064 LUCA
GeneTreeiENSGT00550000075207
HOGENOMiHOG000294685
InParanoidiO45687
KOiK13953
OMAiQYAHNVF
OrthoDBiEOG091G0GBX
PhylomeDBiO45687

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

O45687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSANIPATQ SALIFEKYGG PLEVRQVSVP QPQENELLVK IEYSGICHSD
60 70 80 90 100
LHTWEGDFEY ASICPLIGGH EGAGTVVTIG SKVKGWNIGD RAGIKLINAN
110 120 130 140 150
CLNCEYCKTG HEPLCDHIQN YGIDRHGTFQ EYLTIRDIDA IKVSNDTNLA
160 170 180 190 200
AAAPVLCGGV TAYKSLKATN VKPGQIVVLT GAGGGLGSFG IQYAKAMGMR
210 220 230 240 250
VVAVDHISKE DHCRNLGAEW FVDAFDTPDI VAHIRKLTNG GAHGVVSFAA
260 270 280 290 300
AKKPMEYALE YVRKRGTVVF VGLPKDGTIP LDTLSLICNE ITVKGSIVGS
310 320 330 340 350
RMDVDEAIDF ITRGIVHVPI ELVKLEDVPS VYQRMKDGKV TSRVVVDFSM

R
Length:351
Mass (Da):37,945
Last modified:June 1, 1998 - v1
Checksum:iD806D1DA6AB9AEEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81570 Genomic DNA Translation: CAB04603.1
PIRiT23625
RefSeqiNP_505992.1, NM_073591.3
UniGeneiCel.2991

Genome annotation databases

EnsemblMetazoaiK12G11.4; K12G11.4; WBGene00010791
GeneIDi179628
KEGGicel:CELE_K12G11.4
UCSCiK12G11.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiADH2_CAEEL
AccessioniPrimary (citable) accession number: O45687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health