Reviewed, UniProtKB/Swiss-Prot O45687 (ADH2_CAEEL)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1
Alternative name(s):
    Sorbitol dehydrogenase family protein 2

Gene names

Name:	sodh-2
ORF Names:	K12G11.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homotetramer Potential.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	determination of adult life span Inferred from mutant phenotype. Source: WormBase oxidation reduction Inferred from electronic annotation. Source: InterPro
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Alcohol dehydrogenase 2		PRO_0000160694
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	70	1	Zinc 1; catalytic By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	115	1	Zinc 2 By similarity
	Metal binding	157	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	O45687-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D806D1DA6AB9AEEB	FASTA	351	37,945
	10 20 30 40 50 60 MSSANIPATQ SALIFEKYGG PLEVRQVSVP QPQENELLVK IEYSGICHSD LHTWEGDFEY 70 80 90 100 110 120 ASICPLIGGH EGAGTVVTIG SKVKGWNIGD RAGIKLINAN CLNCEYCKTG HEPLCDHIQN 130 140 150 160 170 180 YGIDRHGTFQ EYLTIRDIDA IKVSNDTNLA AAAPVLCGGV TAYKSLKATN VKPGQIVVLT 190 200 210 220 230 240 GAGGGLGSFG IQYAKAMGMR VVAVDHISKE DHCRNLGAEW FVDAFDTPDI VAHIRKLTNG 250 260 270 280 290 300 GAHGVVSFAA AKKPMEYALE YVRKRGTVVF VGLPKDGTIP LDTLSLICNE ITVKGSIVGS 310 320 330 340 350 RMDVDEAIDF ITRGIVHVPI ELVKLEDVPS VYQRMKDGKV TSRVVVDFSM R

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z81570 Genomic DNA. Translation: CAB04603.1.
PIR	T23625.
RefSeq	NP_505992.1.
UniGene	Cel.2991
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	K12G11.4. Caenorhabditis elegans. [Contig view]
GeneID	179628.
KEGG	cel:K12G11.4.
NMPDR	fig|6239.3.peg.19849.
Organism-specific databases
WormBase	WBGene00010791. sodh-2.
WormPep	K12G11.4. CE12214. [WorfDB]
Gene expression databases
ArrayExpress	O45687.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	906206.

Entry information

Entry name

ADH2_CAEEL

Accession

Primary (citable) accession number: O45687

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project