O45687 (ADH2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 2
EC=1.1.1.1

Alternative name(s):
Sorbitol dehydrogenase family protein 2

Gene names

Name:	sodh-2
ORF Names:	K12G11.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homotetramer Potential.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype. Source: WormBase
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Alcohol dehydrogenase 2		PRO_0000160694
Regions
	Nucleotide binding	181 – 187	7	NAD By similarity
	Nucleotide binding	271 – 273	3	NAD By similarity
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	70	1	Zinc 1; catalytic By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	115	1	Zinc 2 By similarity
	Metal binding	157	1	Zinc 1; catalytic By similarity
	Binding site	205	1	NAD By similarity
	Binding site	209	1	NAD By similarity
	Binding site	343	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	O45687 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D806D1DA6AB9AEEB	FASTA	351	37,945
	10 20 30 40 50 60 MSSANIPATQ SALIFEKYGG PLEVRQVSVP QPQENELLVK IEYSGICHSD LHTWEGDFEY 70 80 90 100 110 120 ASICPLIGGH EGAGTVVTIG SKVKGWNIGD RAGIKLINAN CLNCEYCKTG HEPLCDHIQN 130 140 150 160 170 180 YGIDRHGTFQ EYLTIRDIDA IKVSNDTNLA AAAPVLCGGV TAYKSLKATN VKPGQIVVLT 190 200 210 220 230 240 GAGGGLGSFG IQYAKAMGMR VVAVDHISKE DHCRNLGAEW FVDAFDTPDI VAHIRKLTNG 250 260 270 280 290 300 GAHGVVSFAA AKKPMEYALE YVRKRGTVVF VGLPKDGTIP LDTLSLICNE ITVKGSIVGS 310 320 330 340 350 RMDVDEAIDF ITRGIVHVPI ELVKLEDVPS VYQRMKDGKV TSRVVVDFSM R

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81570 Genomic DNA. Translation: CAB04603.1.
PIR	T23625.
RefSeq	NP_505992.1. NM_073591.2.
UniGene	Cel.2991.
3D structure databases
ProteinModelPortal	O45687.
SMR	O45687. Positions 5-349.
ModBase	Search...
Protein-protein interaction databases
IntAct	O45687. 1 interaction.
STRING	O45687.
Proteomic databases
PRIDE	O45687.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	K12G11.4; K12G11.4; K12G11.4.
GeneID	179628.
KEGG	cel:K12G11.4.
NMPDR	fig|6239.3.peg.19849.
UCSC	K12G11.4. c. elegans.
Organism-specific databases
CTD	41313.
WormBase	K12G11.4; CE12214; WBGene00010791; sodh-2.
Phylogenomic databases
eggNOG	meNOG19304.
GeneTree	EMGT00050000002944.
HOGENOM	HBG753318.
InParanoid	O45687.
OMA	SFGIQYA.
PhylomeDB	O45687.
Gene expression databases
ArrayExpress	O45687.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K13953.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	906206.

Entry information

Entry name

ADH2_CAEEL

Accession

Primary (citable) accession number: O45687

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project