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Reviewed, UniProtKB/Swiss-Prot O45687 (ADH2_CAEEL)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1
Alternative name(s):
    Sorbitol dehydrogenase family protein 2
Gene names
Name: sodh-2
ORF Names: K12G11.4
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer Potential.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdetermination of adult life span

Inferred from mutant phenotype. Source: WormBase

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Alcohol dehydrogenase 2
PRO_0000160694

Regions

Nucleotide binding181 – 1877NAD By similarity
Nucleotide binding271 – 2733NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding701Zinc 1; catalytic By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1071Zinc 2 By similarity
Metal binding1151Zinc 2 By similarity
Metal binding1571Zinc 1; catalytic By similarity
Binding site2051NAD By similarity
Binding site2091NAD By similarity
Binding site3431NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
O45687-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D806D1DA6AB9AEEB

FASTA35137,945
        10         20         30         40         50         60 
MSSANIPATQ SALIFEKYGG PLEVRQVSVP QPQENELLVK IEYSGICHSD LHTWEGDFEY 

        70         80         90        100        110        120 
ASICPLIGGH EGAGTVVTIG SKVKGWNIGD RAGIKLINAN CLNCEYCKTG HEPLCDHIQN 

       130        140        150        160        170        180 
YGIDRHGTFQ EYLTIRDIDA IKVSNDTNLA AAAPVLCGGV TAYKSLKATN VKPGQIVVLT 

       190        200        210        220        230        240 
GAGGGLGSFG IQYAKAMGMR VVAVDHISKE DHCRNLGAEW FVDAFDTPDI VAHIRKLTNG 

       250        260        270        280        290        300 
GAHGVVSFAA AKKPMEYALE YVRKRGTVVF VGLPKDGTIP LDTLSLICNE ITVKGSIVGS 

       310        320        330        340        350 
RMDVDEAIDF ITRGIVHVPI ELVKLEDVPS VYQRMKDGKV TSRVVVDFSM R

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

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Cross-references

Sequence databases

Z81570 Genomic DNA. Translation: CAB04603.1.
PIRT23625.
RefSeqNP_505992.1.
UniGeneCel.2991

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblK12G11.4. Caenorhabditis elegans. [Contig view]
GeneID179628.
KEGGcel:K12G11.4.
NMPDRfig|6239.3.peg.19849.

Organism-specific databases

WormBaseWBGene00010791. sodh-2.
WormPepK12G11.4. CE12214. [WorfDB]

Phylogenomic databases

OMAO45687. LINANCL.

Enzyme and pathway databases

BRENDA1.1.1.1. 672.

Gene expression databases

ArrayExpressO45687.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio906206.

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Entry information

Entry nameADH2_CAEEL
AccessionPrimary (citable) accession number: O45687
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents