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Reviewed, UniProtKB/Swiss-Prot O45686 (ASAH1_CAEEL)

Last modified November 3, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Acid ceramidase
    EC=3.5.1.23
Alternative name(s):
    Acylsphingosine amidohydrolase 1
Gene names
Name: asah-1
ORF Names: K11D2.2
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid By similarity.

Catalytic activity

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Subunit structure

Heterodimer of one alpha and one beta subunit By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the acid ceramidase family.

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Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdetermination of adult lifespan

Inferred from mutant phenotype. Source: WormBase

lipid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionceramidase activity

Inferred from electronic annotation. Source: EC

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

lag-1Q9TYY11EBI-324508,EBI-324482
vps-39Q9XUQ41EBI-324508,EBI-318975

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 393377Acid ceramidase
PRO_0000002322

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
O45686-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 7545366601FDFFF0

FASTA39344,823
        10         20         30         40         50         60 
MLRELSVLLL VAVCAAKHVE LPAPFKDHCI LDDKQNLYDP SKQFDIKWYD VNLDLPPSER 

        70         80         90        100        110        120 
WVQIATANKE HIADLIGVLI NLITPWFPNA IDFVDDVFGD LAPKLAQPYR DEIFSIANAT 

       130        140        150        160        170        180 
GIPLGQITMY NIFYEIFTVC TSVIAQDKDG HVFHARNLDF GLFMGWDPVL HDWQISQKLR 

       190        200        210        220        230        240 
KMIINVNWLK DGKLLYKSNN FAGYIGIYNG LKPNAFSLTA DDRFQLVGGY YGILKWVFGL 

       250        260        270        280        290        300 
EADGKWMSWL ARETLETKTT YLDAKEHLMN TPMLSPVYFI LGGSKKDEGC IIARSLDKTA 

       310        320        330        340        350        360 
LLTEMATSPH GWYLLETNYD QGTEDLYLDD RDTPGFRCMD KLTQKNVGFE GIFNVLSSRT 

       370        380        390 
NLNKLTTYTV LMSVETSRFE TILQSCPGEC YPW

« Hide

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z83115 Genomic DNA. Translation: CAB05556.1.
PIRT23602.
RefSeqNP_493173.1.
UniGeneCel.6266

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:26864N.
IntActO45686. 2 interactions.
STRINGO45686.

Genome annotation databases

EnsemblK11D2.2; K11D2.2; K11D2.2; Caenorhabditis elegans. [Genome view]
GeneID173120.
KEGGcel:K11D2.2.
NMPDRfig|6239.3.peg.3295.
UCSCK11D2.2. c. elegans.

Organism-specific databases

CTD173120.
WormBaseWBGene00010769. asah-1.
WormPepK11D2.2. CE12120. [WorfDB]

Phylogenomic databases

OMANYDRWKN.

Enzyme and pathway databases

BRENDA3.5.1.23. 672.

Gene expression databases

ArrayExpressO45686.

Family and domain databases

InterProIPR016699. Acid_ceramidase-like.
IPR003199. Chologlycine_hydro.
[Graphical view]
PfamPF02275. CBAH. 1 hit.
[Graphical view]
PIRSFPIRSF017632. Acid_ceramidase-like. 1 hit.
ProtoNetSearch...

Other Resources

NextBio878341.

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Entry information

Entry nameASAH1_CAEEL
AccessionPrimary (citable) accession number: O45686
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents