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Protein

Acid ceramidase

Gene

asah-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.By similarity

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-1660662 Glycosphingolipid metabolism
R-CEL-6798695 Neutrophil degranulation
UniPathwayiUPA00222

Protein family/group databases

MEROPSiC89.A02

Names & Taxonomyi

Protein namesi
Recommended name:
Acid ceramidase (EC:3.5.1.23)
Alternative name(s):
Acylsphingosine amidohydrolase 1
Gene namesi
Name:asah-1
ORF Names:K11D2.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK11D2.2 ; CE12120 ; WBGene00010769 ; asah-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000232217 – 393Acid ceramidaseAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO45686
PeptideAtlasiO45686

Expressioni

Gene expression databases

BgeeiWBGene00010769

Interactioni

Subunit structurei

Heterodimer of one alpha and one beta subunit.By similarity

Protein-protein interaction databases

BioGridi38517, 2 interactors
DIPiDIP-26864N
IntActiO45686, 2 interactors
STRINGi6239.K11D2.2.1

Structurei

3D structure databases

ProteinModelPortaliO45686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid ceramidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFSS Eukaryota
ENOG410XQ6Y LUCA
GeneTreeiENSGT00530000063548
HOGENOMiHOG000007253
InParanoidiO45686
KOiK12348
OMAiKQNLYDP
OrthoDBiEOG091G08N9
PhylomeDBiO45686

Family and domain databases

InterProiView protein in InterPro
IPR016699 Acid_ceramidase-like
IPR029130 Acid_ceramidase_N
IPR029132 CBAH/NAAA_C
PfamiView protein in Pfam
PF02275 CBAH, 1 hit
PF15508 NAAA-beta, 1 hit
PIRSFiPIRSF017632 Acid_ceramidase-like, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRELSVLLL VAVCAAKHVE LPAPFKDHCI LDDKQNLYDP SKQFDIKWYD
60 70 80 90 100
VNLDLPPSER WVQIATANKE HIADLIGVLI NLITPWFPNA IDFVDDVFGD
110 120 130 140 150
LAPKLAQPYR DEIFSIANAT GIPLGQITMY NIFYEIFTVC TSVIAQDKDG
160 170 180 190 200
HVFHARNLDF GLFMGWDPVL HDWQISQKLR KMIINVNWLK DGKLLYKSNN
210 220 230 240 250
FAGYIGIYNG LKPNAFSLTA DDRFQLVGGY YGILKWVFGL EADGKWMSWL
260 270 280 290 300
ARETLETKTT YLDAKEHLMN TPMLSPVYFI LGGSKKDEGC IIARSLDKTA
310 320 330 340 350
LLTEMATSPH GWYLLETNYD QGTEDLYLDD RDTPGFRCMD KLTQKNVGFE
360 370 380 390
GIFNVLSSRT NLNKLTTYTV LMSVETSRFE TILQSCPGEC YPW
Length:393
Mass (Da):44,823
Last modified:June 1, 1998 - v1
Checksum:i7545366601FDFFF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83115 Genomic DNA Translation: CAB05556.1
PIRiT23602
RefSeqiNP_493173.1, NM_060772.8
UniGeneiCel.6266

Genome annotation databases

EnsemblMetazoaiK11D2.2.1; K11D2.2.1; WBGene00010769
K11D2.2.2; K11D2.2.2; WBGene00010769
K11D2.2.3; K11D2.2.3; WBGene00010769
GeneIDi173120
KEGGicel:CELE_K11D2.2
UCSCiK11D2.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiASAH1_CAEEL
AccessioniPrimary (citable) accession number: O45686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health