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Protein

Nuclear hormone receptor family member nhr-49

Gene

nhr-49

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 (PubMed:25981666).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 8376Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri11 – 3121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 7125NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter in response to stress Source: WormBase
  • regulation of fatty acid metabolic process Source: WormBase
  • regulation of lipid metabolic process Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-49
Gene namesi
Name:nhr-49
ORF Names:K10C3.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK10C3.6a; CE12084; WBGene00003639; nhr-49.
K10C3.6b; CE28943; WBGene00003639; nhr-49.
K10C3.6c; CE32693; WBGene00003639; nhr-49.
K10C3.6d; CE32694; WBGene00003639; nhr-49.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown eliminates the effect of C11 or C12 chain fatty acids in activating fat-7 expression and blocks overexpression of fat-7 in acdh-11 mutants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Nuclear hormone receptor family member nhr-49PRO_0000053785Add
BLAST

Proteomic databases

EPDiO45666.
PaxDbiO45666.
PRIDEiO45666.

PTM databases

iPTMnetiO45666.

Expressioni

Gene expression databases

ExpressionAtlasiO45666. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mdt-15Q219554EBI-318820,EBI-318240
nhr-13Q9N4Q77EBI-318820,EBI-317894
nhr-181O163465EBI-318820,EBI-2417265
nhr-19Q095284EBI-318820,EBI-318797
nhr-20Q095653EBI-318820,EBI-314918
nhr-234Q9NAJ34EBI-318820,EBI-325014
nhr-76Q65CM04EBI-318820,EBI-324921

Protein-protein interaction databases

BioGridi38262. 21 interactions.
DIPiDIP-24928N.
IntActiO45666. 54 interactions.
MINTiMINT-1048977.
STRINGi6239.K10C3.6c.2.

Structurei

3D structure databases

ProteinModelPortaliO45666.
SMRiO45666. Positions 35-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 3121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 7125NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00840000130053.
InParanoidiO45666.
KOiK08704.
OMAiNERDCIN.
PhylomeDBiO45666.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform c (identifier: O45666-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDYFLDASKH IQLNQIDEES SDDFMDLVDP LAEPCAVCGD KSTGTHYGVI
60 70 80 90 100
SCNGCKGFFR RTVLRDQKFT CRFNKRCVID KNFRCACRYC RFQKCVQVGM
110 120 130 140 150
KREAIQFERD PVGSPTSGAS LNGTPFKKDR SPGYENGNSN GVGSNGMGQE
160 170 180 190 200
NMRTVPQSSS VIDALMEMEA RVNQEMCNRY RRSQIFANGS GGSNGNDTDI
210 220 230 240 250
QQGSDSGASA FAPPNRPCTT EVDLNEISRT TLLLMVEWAK TINPFMDLSM
260 270 280 290 300
EDKIILLKNY APQHLILMPA FRSPDTTRVC LFNNTYMTRD NNTDLNGFAA
310 320 330 340 350
FKTSNITPRV LDEIVWPMRQ LQMREQEFVC LKALAFLHPE AKGLSNSSQI
360 370 380 390 400
MIRDARNRVL KALYAFILDQ MPDDAPTRYG NILLLAPALK ALTQLLIENM
410 420 430 440 450
TLTKFFGLAE VDSLLSEFIL DDINDHSTAP VSLQQHLSSP TTLPTNGVSP
460 470 480 490 500
LNPAGSVGSV SSVSGITPTG MLSATLAAPL AIHPLQSQDS ILNSEQNNHM

L
Note: No experimental confirmation available.
Length:501
Mass (Da):55,388
Last modified:September 27, 2005 - v2
Checksum:iBC69815507B2C811
GO
Isoform a (identifier: O45666-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):52,545
Checksum:i6620540F916C04DD
GO
Isoform b (identifier: O45666-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     222-222: Missing.

Show »
Length:476
Mass (Da):52,446
Checksum:i32EBB2C09315F8DF
GO
Isoform d (identifier: O45666-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MDYFLDASKHIQLNQIDEESSDDF → MKNLQMIVI

Note: No experimental confirmation available.
Show »
Length:486
Mass (Da):53,616
Checksum:iF201F002C8CBD3F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4132DS → PP in AAG15142 (PubMed:15983867).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424Missing in isoform a and isoform b. 1 PublicationVSP_015670Add
BLAST
Alternative sequencei1 – 2424MDYFL…SSDDF → MKNLQMIVI in isoform d. 1 PublicationVSP_015671Add
BLAST
Alternative sequencei222 – 2221Missing in isoform b. CuratedVSP_015672

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83235 Genomic DNA. Translation: CAB05772.1.
Z83235 Genomic DNA. Translation: CAD21653.1.
Z83235 Genomic DNA. Translation: CAD57702.1.
Z83235 Genomic DNA. Translation: CAD57703.1.
AF273792 mRNA. Translation: AAG15140.1.
AF273793 mRNA. Translation: AAG15141.1.
AF273794 mRNA. Translation: AAG15142.1.
AF273795 mRNA. Translation: AAG15143.1.
AF332206 mRNA. Translation: AAK17977.1.
PIRiT23554.
RefSeqiNP_492612.1. NM_060211.4. [O45666-2]
NP_492613.1. NM_060212.4. [O45666-3]
NP_871798.1. NM_181998.4. [O45666-1]
NP_871799.1. NM_181999.4. [O45666-4]
UniGeneiCel.17842.

Genome annotation databases

EnsemblMetazoaiK10C3.6c.1; K10C3.6c.1; WBGene00003639. [O45666-1]
K10C3.6c.2; K10C3.6c.2; WBGene00003639. [O45666-1]
GeneIDi172839.
KEGGicel:CELE_K10C3.6.
UCSCiK10C3.6c.1. c. elegans. [O45666-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83235 Genomic DNA. Translation: CAB05772.1.
Z83235 Genomic DNA. Translation: CAD21653.1.
Z83235 Genomic DNA. Translation: CAD57702.1.
Z83235 Genomic DNA. Translation: CAD57703.1.
AF273792 mRNA. Translation: AAG15140.1.
AF273793 mRNA. Translation: AAG15141.1.
AF273794 mRNA. Translation: AAG15142.1.
AF273795 mRNA. Translation: AAG15143.1.
AF332206 mRNA. Translation: AAK17977.1.
PIRiT23554.
RefSeqiNP_492612.1. NM_060211.4. [O45666-2]
NP_492613.1. NM_060212.4. [O45666-3]
NP_871798.1. NM_181998.4. [O45666-1]
NP_871799.1. NM_181999.4. [O45666-4]
UniGeneiCel.17842.

3D structure databases

ProteinModelPortaliO45666.
SMRiO45666. Positions 35-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38262. 21 interactions.
DIPiDIP-24928N.
IntActiO45666. 54 interactions.
MINTiMINT-1048977.
STRINGi6239.K10C3.6c.2.

PTM databases

iPTMnetiO45666.

Proteomic databases

EPDiO45666.
PaxDbiO45666.
PRIDEiO45666.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK10C3.6c.1; K10C3.6c.1; WBGene00003639. [O45666-1]
K10C3.6c.2; K10C3.6c.2; WBGene00003639. [O45666-1]
GeneIDi172839.
KEGGicel:CELE_K10C3.6.
UCSCiK10C3.6c.1. c. elegans. [O45666-1]

Organism-specific databases

CTDi172839.
WormBaseiK10C3.6a; CE12084; WBGene00003639; nhr-49.
K10C3.6b; CE28943; WBGene00003639; nhr-49.
K10C3.6c; CE32693; WBGene00003639; nhr-49.
K10C3.6d; CE32694; WBGene00003639; nhr-49.

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00840000130053.
InParanoidiO45666.
KOiK08704.
OMAiNERDCIN.
PhylomeDBiO45666.

Miscellaneous databases

PROiO45666.

Gene expression databases

ExpressionAtlasiO45666. baseline.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes."
    Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.
    J. Mol. Evol. 60:577-586(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-501 (ISOFORMS A; C AND D).
  3. "Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids."
    Ma D.K., Li Z., Lu A.Y., Sun F., Chen S., Rothe M., Menzel R., Sun F., Horvitz H.R.
    Cell 161:1152-1163(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNHR49_CAEEL
AccessioniPrimary (citable) accession number: O45666
Secondary accession number(s): Q8I4H3
, Q8I4H4, Q8WQE4, Q9BJL0, Q9GTG4, Q9GTG5, Q9GTG6, Q9GTG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.