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Protein
Submitted name:

Sodium-calcium exchanger

Gene
N/A
Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-425561. Sodium/Calcium exchangers.
R-CEL-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium-calcium exchangerImported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7722HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13922HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17222HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20724HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Transmembranei749 – 77022HelicalSequence analysisAdd
BLAST
Transmembranei827 – 84721HelicalSequence analysisAdd
BLAST
Transmembranei859 – 87921HelicalSequence analysisAdd
BLAST
Transmembranei899 – 92224HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 925903Sequence analysisPRO_5004158353Add
BLAST

Proteomic databases

EPDiO45630.

Expressioni

Gene expression databases

ExpressionAtlasiO45630. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini356 – 456101Calx-betaInterPro annotationAdd
BLAST
Domaini487 – 586100Calx-betaInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sodium/potassium/calcium exchanger family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOGENOMiHOG000266971.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.

Sequencei

Sequence statusi: Complete.

O45630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRFGCWLAV AFLVALAGLA DAGSNCSAAD ATRNCIDGLV IPIWRPFLDL
60 70 80 90 100
TTGDRVLRGV LYFFVIAYMF LGISIVADRF MSSIEVITSM ERTIVVKRPG
110 120 130 140 150
LDPMAVQVRI WNDTVSNLTL MALGSSAPEI LLSIIEVIAR GFEAGDLGPN
160 170 180 190 200
TIVGSAAFNL FMIIAICVVV IPKGEIRRQK HLDVFCVTAT WSVFAYVWLY
210 220 230 240 250
LILAFFSPGE IEIWEGALTF IFFPLTVFTA YMADIKLIQN KFLPHRYRRG
260 270 280 290 300
SHGQMIATEA EEMKMLENGT QGDPALKAFE EHRQEFIELM REIRKQNPHI
310 320 330 340 350
TPTELQKQAE YEMISRGPKS RAFYRVQATR RLIGGGDIVK KRIDKEHNKA
360 370 380 390 400
LDALVQAQEK QSRDNTCKIF LDPAHYTVLE SVGSFDVVVG RDGGPDGLTV
410 420 430 440 450
MVDYFTEDGS ANAGSDYIPV KGTLTFYPED KHQKVTIEVV DDDVFEEDEH
460 470 480 490 500
FYLRLCNLRV RTKDGIIIDP TRIGGLPVAQ LEMPNTATIM ILDDDHAGVF
510 520 530 540 550
GFEHDHFQVV ENCGHLSLQM KRHSGARGKV IIPFRTVEGT ASADKHFEMK
560 570 580 590 600
EGEIVFEDNQ TEALVEIGIV DTEQYERSDY FYIELSPPIW AKKMNDLSRI
610 620 630 640 650
QERFQRRMER KRGSSVASES KDSNTENGDD EVTTSLTPSQ LEIAEMGKPR
660 670 680 690 700
LGEFTKCQIT IRESKEFQGI VDRMIKNANT RIMLGTHSWR EQFMEALVVS
710 720 730 740 750
AGDDDDDEGE DGEDGEEKEP EEPGCMDYVM HVLTVPWKLT FATIPPTDYF
760 770 780 790 800
GGWATFVVAI FMIGVLTAVV GDLASQFGCW VGLKDAVTAI SFVALGTSVP
810 820 830 840 850
DTFASKVSAV QDKYADNAVG NVTGSNAVNV FLGIGIAWSM AAIYHWNQGT
860 870 880 890 900
KFLVDPGNLG FSVLIFCTEA VLCIIVLVLR RNKKVGGELG GPIALRWMTA
910 920
MFFASLWFMY LLLSALEAYC IIPGF
Length:925
Mass (Da):103,152
Last modified:June 1, 1998 - v1
Checksum:i8EAA48870CEC0CAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001181 mRNA. Translation: CAA04574.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001181 mRNA. Translation: CAA04574.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiO45630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000266971.

Enzyme and pathway databases

ReactomeiR-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-425561. Sodium/Calcium exchangers.
R-CEL-5578775. Ion homeostasis.

Gene expression databases

ExpressionAtlasiO45630. baseline and differential.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR032452. Na_Ca_Ex_C-exten.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
PF16494. Na_Ca_ex_C. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
SMARTiSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00845. caca. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A gene family, coding for sodium-calcium exchangers in C.elegans."
    Kraev A., Carafoli E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CB1489 him-8Imported.
  2. Kraev A.S.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CB1489 him-8Imported.

Entry informationi

Entry nameiO45630_CAEEL
AccessioniPrimary (citable) accession number: O45630
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.