Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Eukaryotic Release FActor homolog

Gene

erfa-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-72764. Eukaryotic Translation Termination.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic Release FActor homologImported
Gene namesi
Name:erfa-3Imported
ORF Names:CELE_H19N07.1Imported, H19N07.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiH19N07.1a; CE32460; WBGene00010405; erfa-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiO45622.
PaxDbiO45622.

2D gel databases

World-2DPAGE0011:O45622.

Expressioni

Gene expression databases

ExpressionAtlasiO45622. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-25705N.
IntActiO45622. 1 interaction.
MINTiMINT-1080325.
STRINGi6239.H19N07.1a.1.

Structurei

3D structure databases

ProteinModelPortaliO45622.
SMRiO45622. Positions 23-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 333227Tr-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0459. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
InParanoidiO45622.
KOiK03267.
OMAiAQENTEI.
PhylomeDBiO45622.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWNVNASS FVPNANARPF VPGQPYTPQP EQAAPEPTED WEAQADTSPA
60 70 80 90 100
AVQPEVAEPV AVQESAPVAP VSATEAPKKE PTPEEDLVAP LAKKFQRTVY
110 120 130 140 150
VDDGTHKEHI NMVFVGHVDA GKSTIGGQLM FLTGMVDKRT LEKYEREAKE
160 170 180 190 200
KGRESWYLSW CMDTNDEERE KGKTVEVGRA YFETEKRHFT ILDAPGHKSF
210 220 230 240 250
VPNMIVGANQ ADLAVLVISA RRGEFETGFD RGGQTREHSM LVKTAGVKHL
260 270 280 290 300
VILVNKMDDP TVKWEEERFK EIEGKLTPFL RKLGFNPKTD ITYVPCSGLT
310 320 330 340 350
GAFIKDRPTG SEGNWYSGPC FIEFIDVLLP SYKRDFNGPV RCTVAEKYSE
360 370 380 390 400
MGTVIIGKME SGCVQKGDTL VVMPNKQPVQ VLQIWADDVE TERVVAGDNI
410 420 430 440 450
KFKLKGIEEN ELQGGFIICS PDSLAKTGRV FDAEVLVLEH RSIIASGYSC
460 470 480 490 500
VLHIQSAVEE VTVKGVIATI DKKTGEKKRA KFVKQDEKCI MRLESPEPFV
510 520 530
LEPFKEYPYL GRFTLRDEGK TIAIGKVLKV VE
Length:532
Mass (Da):59,163
Last modified:March 1, 2003 - v2
Checksum:i89FF494C6BE6F1CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07395.2.
PIRiT23102.
RefSeqiNP_001256292.1. NM_001269363.1.
UniGeneiCel.17395.

Genome annotation databases

EnsemblMetazoaiH19N07.1a.1; H19N07.1a.1; WBGene00010405.
H19N07.1a.2; H19N07.1a.2; WBGene00010405.
GeneIDi179537.
KEGGicel:CELE_H19N07.1.
UCSCiH19N07.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07395.2.
PIRiT23102.
RefSeqiNP_001256292.1. NM_001269363.1.
UniGeneiCel.17395.

3D structure databases

ProteinModelPortaliO45622.
SMRiO45622. Positions 23-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25705N.
IntActiO45622. 1 interaction.
MINTiMINT-1080325.
STRINGi6239.H19N07.1a.1.

2D gel databases

World-2DPAGE0011:O45622.

Proteomic databases

EPDiO45622.
PaxDbiO45622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH19N07.1a.1; H19N07.1a.1; WBGene00010405.
H19N07.1a.2; H19N07.1a.2; WBGene00010405.
GeneIDi179537.
KEGGicel:CELE_H19N07.1.
UCSCiH19N07.1.1. c. elegans.

Organism-specific databases

CTDi179537.
WormBaseiH19N07.1a; CE32460; WBGene00010405; erfa-3.

Phylogenomic databases

eggNOGiKOG0459. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
InParanoidiO45622.
KOiK03267.
OMAiAQENTEI.
PhylomeDBiO45622.

Enzyme and pathway databases

ReactomeiR-CEL-72764. Eukaryotic Translation Termination.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Gene expression databases

ExpressionAtlasiO45622. baseline.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO45622_CAEEL
AccessioniPrimary (citable) accession number: O45622
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.