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Protein

Chitin-binding domain protein cbd-1

Gene

cbd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chitin metabolic process Source: InterPro
  • eggshell formation Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of protein localization to cell cortex Source: UniProtKB
  • positive regulation of protein localization to plasma membrane Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
LigandChitin-binding

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14

Names & Taxonomyi

Protein namesi
Recommended name:
Chitin-binding domain protein cbd-1Imported
Gene namesi
Name:cbd-1Imported
ORF Names:H02I12.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiH02I12.1 ; CE37527 ; WBGene00010351 ; cbd-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes the zygote to exit the spermatheca with a pinched morphology and to leave a trailing section behind. Zygotes have a fragmented chitin eggshell with an accumulation of chitin at one end of the embryo, causing polyspermy. In unfertilized oocytes, disrupts the homogenous distribution of cortical chitin synthase chs-1, pseudophosphatase egg-3 and kinase mbk-2 and causes the loss of egg-1 and egg-2 cell membrane localization resulting in their premature accumulation in cytoplasmic puncta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500415835120 – 1319Chitin-binding domain protein cbd-1Add BLAST1300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 72PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi222 ↔ 235PROSITE-ProRule annotation
Glycosylationi327N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi335 ↔ 348PROSITE-ProRule annotation
Disulfide bondi601 ↔ 614PROSITE-ProRule annotation
Disulfide bondi721 ↔ 734PROSITE-ProRule annotation
Disulfide bondi814 ↔ 827PROSITE-ProRule annotation
Disulfide bondi916 ↔ 929PROSITE-ProRule annotation
Glycosylationi1016N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1060 ↔ 1073PROSITE-ProRule annotation
Disulfide bondi1139 ↔ 1152PROSITE-ProRule annotation
Disulfide bondi1213 ↔ 1226PROSITE-ProRule annotation
Disulfide bondi1274 ↔ 1287PROSITE-ProRule annotation
Glycosylationi1304N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO45599
PaxDbiO45599
PeptideAtlasiO45599

Expressioni

Gene expression databases

BgeeiWBGene00010351

Interactioni

Protein-protein interaction databases

DIPiDIP-26633N
IntActiO45599, 4 interactors
STRINGi6239.H02I12.1.2

Structurei

3D structure databases

ProteinModelPortaliO45599
SMRiO45599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 83Chitin-binding type-2 1PROSITE-ProRule annotationAdd BLAST56
Domaini96 – 141Chitin-binding type-2 2PROSITE-ProRule annotationAdd BLAST46
Domaini190 – 236Chitin-binding type-2 3PROSITE-ProRule annotationAdd BLAST47
Domaini304 – 357Chitin-binding type-2 4PROSITE-ProRule annotationAdd BLAST54
Domaini566 – 614Chitin-binding type-2 5PROSITE-ProRule annotationAdd BLAST49
Domaini689 – 745Chitin-binding type-2 6PROSITE-ProRule annotationAdd BLAST57
Domaini782 – 838Chitin-binding type-2 7PROSITE-ProRule annotationAdd BLAST57
Domaini883 – 942Chitin-binding type-2 8PROSITE-ProRule annotationAdd BLAST60
Domaini1029 – 1081Chitin-binding type-2 9PROSITE-ProRule annotationAdd BLAST53
Domaini1105 – 1163Chitin-binding type-2 10PROSITE-ProRule annotationAdd BLAST59
Domaini1179 – 1237Chitin-binding type-2 11PROSITE-ProRule annotationAdd BLAST59
Domaini1242 – 1298Chitin-binding type-2 12PROSITE-ProRule annotationAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 303Thr-richPROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J1SU Eukaryota
ENOG41121EJ LUCA
GeneTreeiENSGT00650000093766
HOGENOMiHOG000016451
InParanoidiO45599
OMAiHTTSSEY
OrthoDBiEOG091G0LTG

Family and domain databases

InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
PfamiView protein in Pfam
PF01607 CBM_14, 7 hits
SMARTiView protein in SMART
SM00494 ChtBD2, 12 hits
SUPFAMiSSF57625 SSF57625, 8 hits
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 12 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPQLATVSL LLLTFFSNSI QYPHSPAATE CPAYFNGNIA GNACSREYSI
60 70 80 90 100
CVNGVRQAAT CSDDSVFYED ECVPVDESPE CRVDENTEED DTPYAEFDCT
110 120 130 140 150
SKQDGIYSIG CSNQFISCVA GGAYMAKCPD SLVFNERTQD CRESCDEVKQ
160 170 180 190 200
DTTTAPQVYE DGEEGYGEAS GEIAGDYERQ PSNEQPDSID FDCNGLEDGN
210 220 230 240 250
YADGCNDVFY SCSNNMVFQR YCPPGTVFNI NQQSCDFQCT TDDPTTTVSY
260 270 280 290 300
STSTITTPQE DDSEYSSTTS ADVISTTTTP SIDAIETTTT GFDAVTTTTT
310 320 330 340 350
TQTPFVCQEG QVNSFGMCSS RFNRCQNNSV RSKQCPVNTL FESSLVMCVF
360 370 380 390 400
DLPQCQPITV PAAPAYNSYG PPSDTIVSPF DENVRLKPKF DRRRKYHHGK
410 420 430 440 450
PSYGPVNGNS YLENPFFIPR HRGGSHRDHR RYGYGPAIDS PFSTAFRGRA
460 470 480 490 500
ALSDQFKDYR RARMGKIQGD ARKVDGNKRF LIDDEFEGPN AKFVESNIEQ
510 520 530 540 550
VFPKNRHSKK QLGPHEDPDG YDDEKTFDAK DLFGATRRKR SAYYGTEQSV
560 570 580 590 600
YGQQSAQISA RQAQVNKDCQ QYTTPTFLTF GDCFDQFIFC SGNGINRMAA
610 620 630 640 650
CPIGETFDKT LRSCSETCGV STTIVAVTIG TQTSDDLSAP SEYIENDGVT
660 670 680 690 700
TQSTWNDQPS TTQAPNSYES YTTQYSSNDV PSTSAAPIGD RCSLDASGLF
710 720 730 740 750
SLGCSQKYIQ CSNGAAIVRR CGESLYFNEA TQECTYRDEV PECGSQGSTS
760 770 780 790 800
SPVITTPGQD QSSNYYGIPS DDVPSTTQTP VGDRCAYVAS GLFDLGCSQK
810 820 830 840 850
YIQCSDSAAS VRECEGSLYF DERSQSCRFR DEVFKCQTAD VSSSSTVPYL
860 870 880 890 900
DFTTTPASPS EDEPTTYEPS VAPYIPSVTV NPVDTCTSLS DGTHGTGCSS
910 920 930 940 950
FYFVCSHGRL ISSGNCQLGE GYDPSVQGCR TFSEIPARAC DEQEVTTDAG
960 970 980 990 1000
LVQLMPYKTL EEVLTTTEAA TTVANDGPTD TYITGSTKYS TTDSGEYTIP
1010 1020 1030 1040 1050
YGDETTSTRS YDRADNDSED EEEDDVEHDQ KCTVGSRTPV GFCVRTYLEC
1060 1070 1080 1090 1100
TDAGNVEKLC RIGKLFDSHS NRCVPRIGCG KEAIRDAIKD MIATTPAPAQ
1110 1120 1130 1140 1150
PKQFEGRCAH VDGEAVFSIG VCSSKYLRCS YGASKLQQCS EDRVFSNDKL
1160 1170 1180 1190 1200
ECIVRESVSA CTVPKNPSIK KYYTSNDQSA FCDGKEDGLY RNERDCSAIL
1210 1220 1230 1240 1250
QCFGGELFEH PSCQSSLAFN QLTGKCDYPQ KVSGCENHGQ TNGECSEHGS
1260 1270 1280 1290 1300
FIADANNCEV FYRCVWGRKV VMTCPSGTVF NPLLSVCDWP SAVPSCSGQA
1310
SDSNSSYGSS TYNDDKSGY
Length:1,319
Mass (Da):144,194
Last modified:November 23, 2004 - v2
Checksum:i2B50C8656061FB3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAB07215.2
PIRiT23024
RefSeqiNP_502145.2, NM_069744.5
UniGeneiCel.17059

Genome annotation databases

EnsemblMetazoaiH02I12.1; H02I12.1; WBGene00010351
GeneIDi178061
KEGGicel:CELE_H02I12.1
UCSCiH02I12.1 c. elegans

Entry informationi

Entry nameiCBD1_CAEEL
AccessioniPrimary (citable) accession number: O45599
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2018
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

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