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Protein
Submitted name:

NEPrilysin metallopeptidase family

Gene

nep-17

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM13.A19.

Names & Taxonomyi

Protein namesi
Submitted name:
NEPrilysin metallopeptidase familyImported
Gene namesi
Name:nep-17Imported
ORF Names:CELE_F54F11.2Imported, F54F11.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF54F11.2a; CE11095; WBGene00010070; nep-17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO45569.
PaxDbiO45569.
PRIDEiO45569.

Expressioni

Gene expression databases

BgeeiWBGene00010070.
ExpressionAtlasiO45569. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F54F11.2a.

Structurei

3D structure databases

ProteinModelPortaliO45569.
SMRiO45569. Positions 107-833, 879-1583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 558445Peptidase_M13_NInterPro annotationAdd
BLAST
Domaini619 – 831213Peptidase_M13InterPro annotationAdd
BLAST
Domaini886 – 1308423Peptidase_M13_NInterPro annotationAdd
BLAST
Domaini1369 – 1582214Peptidase_M13InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000021923.
InParanoidiO45569.
OMAiMSFAQVW.
OrthoDBiEOG091G00FM.

Family and domain databases

CDDicd08662. M13. 2 hits.
Gene3Di3.40.390.10. 6 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 2 hits.
PF05649. Peptidase_M13_N. 2 hits.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

O45569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPGSGNIV HTLLLVAGIV LTAGVLGVVI AILVNENNTN TNTNTIYNGT
60 70 80 90 100
NTYNSTIQYN STYVYNSTII EIDIASKVLN VAQPAKVSPG TDKYNSYQQV
110 120 130 140 150
VQLFKASVNL SVDPCNDFYA YTCGNFKGDM SFDISDNSNT NDMVTRLTND
160 170 180 190 200
TYISTAPLPV QQTRWYFDTC VNARQNWNTI ADGSVVTAAI NQLAAGNPGK
210 220 230 240 250
HENSTKFPFP MLDQKTDVTT FPDRFGLGYL TGSLTAQGVD TIISAGVDTN
260 270 280 290 300
WKDPAGPEGF AYLIDQPTTF APNTYYLKDF DALNASLTYQ ITENMLQLAK
310 320 330 340 350
VQNKTLDANI LAKDVQDIIK LDYLLATKFS TDDTTRRQYD RSYNPNTLPQ
360 370 380 390 400
LLTQYHKDVF SWHMFLPIAV GTAEHVLDKL LDQGSGYNYY ITMEPTKLNM
410 420 430 440 450
LLTSLNKDNT LGITPRALVN YFYYRLVDSL SEFLPAPPAG NMIRPFVKIE
460 470 480 490 500
RQPVGRPRHV LPEDRKYERK LIEDLTEAQY SCAQETIDIQ YANARLFIDQ
510 520 530 540 550
IYPTATDRKN VREHVAKVAS SIVIGFRSMI DQLNWMTPST KKGAYNKIEN
560 570 580 590 600
LVKNIAYPDW ITDDAQLTAY HAPMNFTKTD TYVDMFFNVQ NFNLYSQWDQ
610 620 630 640 650
LVQGPADRTG FNGPPGITNA WYQPELNSIT FPAGILKKPF YDFNWPASVN
660 670 680 690 700
FGAMGVIAGH ELTHGFDDQG VQWNGVGTLS GWMDATSKVS FTNMAQCVVN
710 720 730 740 750
EYSGFCPLDK ATYGSAACID GAQTQGENIA DNGGIHSAFR AYKNYVDLYG
760 770 780 790 800
PDPVLPDPQL QYFNPDQLFF LSFAQVWCQM PYTDAQFLRQ ILVDVHSPSI
810 820 830 840 850
YRVLGTIQNF PAFKTAFNCP SSTYAPDNHC NVWVSDIDTT FGLPNVKTDI
860 870 880 890 900
NVVPEAPITS TNVDKMNAYQ MAVDYYAKSV NTAIDPCDDF YSYACGNFNQ
910 920 930 940 950
SVSFYTARAQ NLVYMAQKLE DPTYQTTINS SPALKKEKQL YNACLTATAS
960 970 980 990 1000
SQSEDQILIS KNYIQTKVDD LKTLIGQDFT LVNGGAPKLP SAKQIGDALG
1010 1020 1030 1040 1050
YLSFEQGIDT LISPLVDTYW IDNSKGYQMF IDQNTAYLSK TYYQPAAWKI
1060 1070 1080 1090 1100
EKPKYLKMAL DVVTRYAREQ NITLPAGASD LLSNVLDYEQ NIAVKYSTDD
1110 1120 1130 1140 1150
NTRRQFQRSW NLTKTSDLVT KYNFMDWMTY LSHAPNAVKA KITDANYQVS
1160 1170 1180 1190 1200
VMEVDRLTHF SADYLQQSPE LLVNLLFVRL LLGNAQYIPS YASAFRGMTD
1210 1220 1230 1240 1250
ESIFLGLSRR KTIPNHIPPP NFDLEANGPA CASVANNLMQ FANGRVFVDY
1260 1270 1280 1290 1300
MYPTAQDVTN IRKSAGGIIK NVISSFQGMI DQLDWMAPDT KQKAYAKTVQ
1310 1320 1330 1340 1350
IQQNIAFPDW IKNDTLLGNY YSTLVIADSD NFYDIYDKLI KFNIFVQYNQ
1360 1370 1380 1390 1400
LNAAQTDRTD FLGQPGTVNA WYQPELNSIT FPAGILVPPY FNPNWPPSIN
1410 1420 1430 1440 1450
YGGMGLVAGH ELTHGFDDQG VQWGPTGNLA RWMDDNSMAG FKNMSQCVIN
1460 1470 1480 1490 1500
EYSGFCPLNA TNYSPNCVKG PQTQGENIAD NGGVHAAFNA YKTHQSLDGP
1510 1520 1530 1540 1550
DPRLPDRLFG QFTHDQLFFM SFAQVWCEVR RTDDALYTQI MVDPHSPSMY
1560 1570 1580
RVYGTIQNFP AFQTAFNCPL GSKSAPEQHC EVWVPGKYQ
Length:1,589
Mass (Da):178,049
Last modified:June 1, 1998 - v1
Checksum:iD2A1A57168287291
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAB05739.1.
PIRiT22668.
RefSeqiNP_001254395.1. NM_001267466.1.
UniGeneiCel.17623.

Genome annotation databases

EnsemblMetazoaiF54F11.2a; F54F11.2a; WBGene00010070.
GeneIDi174996.
KEGGicel:CELE_F54F11.2.
UCSCiF54F11.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAB05739.1.
PIRiT22668.
RefSeqiNP_001254395.1. NM_001267466.1.
UniGeneiCel.17623.

3D structure databases

ProteinModelPortaliO45569.
SMRiO45569. Positions 107-833, 879-1583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F54F11.2a.

Protein family/group databases

MEROPSiM13.A19.

Proteomic databases

EPDiO45569.
PaxDbiO45569.
PRIDEiO45569.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF54F11.2a; F54F11.2a; WBGene00010070.
GeneIDi174996.
KEGGicel:CELE_F54F11.2.
UCSCiF54F11.2. c. elegans.

Organism-specific databases

CTDi174996.
WormBaseiF54F11.2a; CE11095; WBGene00010070; nep-17.

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000021923.
InParanoidiO45569.
OMAiMSFAQVW.
OrthoDBiEOG091G00FM.

Gene expression databases

BgeeiWBGene00010070.
ExpressionAtlasiO45569. baseline.

Family and domain databases

CDDicd08662. M13. 2 hits.
Gene3Di3.40.390.10. 6 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 2 hits.
PF05649. Peptidase_M13_N. 2 hits.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Entry informationi

Entry nameiO45569_CAEEL
AccessioniPrimary (citable) accession number: O45569
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.