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O45539

- O45539_CAEEL

UniProt

O45539 - O45539_CAEEL

Protein
Submitted name:

Protein SRC-2

Gene

src-2

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein tyrosine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiO45539.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein SRC-2Imported
    Gene namesi
    Name:src-2Imported
    ORF Names:CELE_F49B2.5Imported, F49B2.5Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiF49B2.5; CE24991; WBGene00005078; src-2.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-26743N.
    IntActiO45539. 43 interactions.
    MINTiMINT-117088.

    Structurei

    3D structure databases

    ProteinModelPortaliO45539.
    SMRiO45539. Positions 62-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SH3 domain.UniRule annotation
    Contains SH2 domain.SAAS annotation
    Contains SH3 domain.SAAS annotation
    Contains SHdomain.SAAS annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    SH3 domainUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00640000091347.
    HOGENOMiHOG000233858.
    InParanoidiO45539.
    KOiK08892.
    OMAiRIRQLDH.
    OrthoDBiEOG7GTT2V.
    PhylomeDBiO45539.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O45539-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSCIGKEDP PPGATSPVHT SSTLGRESLP SHPRIPSIGP IAASSSGNTI    50
    DKNQNISQSA NFVALFQYDA RTDDDLSFKK DDILEILNDT QGDWWFARHK 100
    ATGRTGYIPS NYVAREKSIE SQPWYFGKMR RIDAEKCLLH TLNEHGAFLV 150
    RDSESRQHDL SLSVRENDSV KHYRIRQLDH GGYFIARRRP FATLHDLIAH 200
    YQREADGLCV NLGAPCAKSE APQTTTFTYD DQWEVDRRSV RLIRQIGAGQ 250
    FGEVWEGRWN VNVPVAVKKL KAGTADPTDF LAEAQIMKKL RHPKLLSLYA 300
    VCTRDEPILI VTELMQENLL TFLQRRGRQC QMPQLVEISA QVAAGMAYLE 350
    EMNFIHRDLA ARNILINNSL SVKIADFGLA RILMKENEYE ARTGARFPIK 400
    WTAPEAANYN RFTTKSDVWS FGILLTEIVT FGRLPYPGMT NAEVLQQVDA 450
    GYRMPCPAGC PVTLYDIMQQ CWRSDPDKRP TFETLQWKLE DLFNLDSSEY 500
    KEASINF 507
    Length:507
    Mass (Da):57,530
    Last modified:May 1, 2000 - v2
    Checksum:iCD3DC68FC91ED86D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81543 Genomic DNA. Translation: CAB04427.2.
    PIRiT22405.
    RefSeqiNP_493502.1. NM_061101.4.
    UniGeneiCel.18455.

    Genome annotation databases

    EnsemblMetazoaiF49B2.5; F49B2.5; WBGene00005078.
    GeneIDi173296.
    KEGGicel:CELE_F49B2.5.
    UCSCiF49B2.5. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z81543 Genomic DNA. Translation: CAB04427.2 .
    PIRi T22405.
    RefSeqi NP_493502.1. NM_061101.4.
    UniGenei Cel.18455.

    3D structure databases

    ProteinModelPortali O45539.
    SMRi O45539. Positions 62-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-26743N.
    IntActi O45539. 43 interactions.
    MINTi MINT-117088.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F49B2.5 ; F49B2.5 ; WBGene00005078 .
    GeneIDi 173296.
    KEGGi cel:CELE_F49B2.5.
    UCSCi F49B2.5. c. elegans.

    Organism-specific databases

    CTDi 173296.
    WormBasei F49B2.5 ; CE24991 ; WBGene00005078 ; src-2.

    Phylogenomic databases

    GeneTreei ENSGT00640000091347.
    HOGENOMi HOG000233858.
    InParanoidi O45539.
    KOi K08892.
    OMAi RIRQLDH.
    OrthoDBi EOG7GTT2V.
    PhylomeDBi O45539.

    Enzyme and pathway databases

    SignaLinki O45539.

    Miscellaneous databases

    NextBioi 879039.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.

    Entry informationi

    Entry nameiO45539_CAEEL
    AccessioniPrimary (citable) accession number: O45539
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 1998
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3