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O45539 (O45539_CAEEL) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Protein SRC-2 EMBL CAB04427.2
Gene names
Name:src-2 EMBL CAB04427.2 WormBase F49B2.5
ORF Names:CELE_F49B2.5 EMBL CAB04427.2
OrganismCaenorhabditis elegans [Reference proteome] EMBL CAB04427.2
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266

Sequence similarities

Contains 1 SH2 domain. SAAS SAAS008266

Contains 1 SH3 domain. RuleBase RU003338 SAAS SAAS008266

Contains 1 protein kinase domain. SAAS SAAS008266

Sequences

Sequence LengthMass (Da)Tools
O45539 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: CD3DC68FC91ED86D

FASTA50757,530
        10         20         30         40         50         60 
MGSCIGKEDP PPGATSPVHT SSTLGRESLP SHPRIPSIGP IAASSSGNTI DKNQNISQSA 

        70         80         90        100        110        120 
NFVALFQYDA RTDDDLSFKK DDILEILNDT QGDWWFARHK ATGRTGYIPS NYVAREKSIE 

       130        140        150        160        170        180 
SQPWYFGKMR RIDAEKCLLH TLNEHGAFLV RDSESRQHDL SLSVRENDSV KHYRIRQLDH 

       190        200        210        220        230        240 
GGYFIARRRP FATLHDLIAH YQREADGLCV NLGAPCAKSE APQTTTFTYD DQWEVDRRSV 

       250        260        270        280        290        300 
RLIRQIGAGQ FGEVWEGRWN VNVPVAVKKL KAGTADPTDF LAEAQIMKKL RHPKLLSLYA 

       310        320        330        340        350        360 
VCTRDEPILI VTELMQENLL TFLQRRGRQC QMPQLVEISA QVAAGMAYLE EMNFIHRDLA 

       370        380        390        400        410        420 
ARNILINNSL SVKIADFGLA RILMKENEYE ARTGARFPIK WTAPEAANYN RFTTKSDVWS 

       430        440        450        460        470        480 
FGILLTEIVT FGRLPYPGMT NAEVLQQVDA GYRMPCPAGC PVTLYDIMQQ CWRSDPDKRP 

       490        500 
TFETLQWKLE DLFNLDSSEY KEASINF

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
Caenorhabditis elegans Sequencing Consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2 EMBL CAB04427.2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z81543 Genomic DNA. Translation: CAB04427.2.
PIRT22405.
RefSeqNP_493502.1. NM_061101.4.

3D structure databases

HSSPHSSP built from PDB template 2PTK based on UniProtKB P00523.
ProteinModelPortalO45539.
SMRO45539. Positions 62-501.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-26743N.
IntActO45539. 3 interactions.
MINTMINT-117088.
STRINGO45539.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF49B2.5; F49B2.5; F49B2.5.
GeneID173296.
KEGGcel:CELE_F49B2.5.
UCSCF49B2.5. c. elegans.

Organism-specific databases

CTD173296.
WormBaseF49B2.5; CE24991; WBGene00005078; src-2.

Phylogenomic databases

GeneTreeENSGT00620000087702.
HOGENOMHOG000233858.
InParanoidO45539.
KOK08892.
OMACVRSKED.

Gene expression databases

ArrayExpressO45539.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio879039.

Entry information

Entry nameO45539_CAEEL
AccessionPrimary (citable) accession number: O45539
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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