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O45539

- O45539_CAEEL

UniProt

O45539 - O45539_CAEEL

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Protein
Submitted name:

Protein SRC-2

Gene

src-2

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein tyrosine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO45539.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein SRC-2Imported
Gene namesi
Name:src-2Imported
ORF Names:CELE_F49B2.5Imported, F49B2.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiF49B2.5; CE24991; WBGene00005078; src-2.

Expressioni

Gene expression databases

ExpressionAtlasiO45539. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-26743N.
IntActiO45539. 43 interactions.
MINTiMINT-117088.

Structurei

3D structure databases

ProteinModelPortaliO45539.
SMRiO45539. Positions 62-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation
Contains SH2 domain.SAAS annotation
Contains SH3 domain.SAAS annotation
Contains SHdomain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
InParanoidiO45539.
KOiK08892.
OMAiRIRQLDH.
OrthoDBiEOG7GTT2V.
PhylomeDBiO45539.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45539-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSCIGKEDP PPGATSPVHT SSTLGRESLP SHPRIPSIGP IAASSSGNTI
60 70 80 90 100
DKNQNISQSA NFVALFQYDA RTDDDLSFKK DDILEILNDT QGDWWFARHK
110 120 130 140 150
ATGRTGYIPS NYVAREKSIE SQPWYFGKMR RIDAEKCLLH TLNEHGAFLV
160 170 180 190 200
RDSESRQHDL SLSVRENDSV KHYRIRQLDH GGYFIARRRP FATLHDLIAH
210 220 230 240 250
YQREADGLCV NLGAPCAKSE APQTTTFTYD DQWEVDRRSV RLIRQIGAGQ
260 270 280 290 300
FGEVWEGRWN VNVPVAVKKL KAGTADPTDF LAEAQIMKKL RHPKLLSLYA
310 320 330 340 350
VCTRDEPILI VTELMQENLL TFLQRRGRQC QMPQLVEISA QVAAGMAYLE
360 370 380 390 400
EMNFIHRDLA ARNILINNSL SVKIADFGLA RILMKENEYE ARTGARFPIK
410 420 430 440 450
WTAPEAANYN RFTTKSDVWS FGILLTEIVT FGRLPYPGMT NAEVLQQVDA
460 470 480 490 500
GYRMPCPAGC PVTLYDIMQQ CWRSDPDKRP TFETLQWKLE DLFNLDSSEY

KEASINF
Length:507
Mass (Da):57,530
Last modified:May 1, 2000 - v2
Checksum:iCD3DC68FC91ED86D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81543 Genomic DNA. Translation: CAB04427.2.
PIRiT22405.
RefSeqiNP_493502.1. NM_061101.4.
UniGeneiCel.18455.

Genome annotation databases

EnsemblMetazoaiF49B2.5; F49B2.5; WBGene00005078.
GeneIDi173296.
KEGGicel:CELE_F49B2.5.
UCSCiF49B2.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81543 Genomic DNA. Translation: CAB04427.2 .
PIRi T22405.
RefSeqi NP_493502.1. NM_061101.4.
UniGenei Cel.18455.

3D structure databases

ProteinModelPortali O45539.
SMRi O45539. Positions 62-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-26743N.
IntActi O45539. 43 interactions.
MINTi MINT-117088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F49B2.5 ; F49B2.5 ; WBGene00005078 .
GeneIDi 173296.
KEGGi cel:CELE_F49B2.5.
UCSCi F49B2.5. c. elegans.

Organism-specific databases

CTDi 173296.
WormBasei F49B2.5 ; CE24991 ; WBGene00005078 ; src-2.

Phylogenomic databases

GeneTreei ENSGT00760000118938.
HOGENOMi HOG000233858.
InParanoidi O45539.
KOi K08892.
OMAi RIRQLDH.
OrthoDBi EOG7GTT2V.
PhylomeDBi O45539.

Enzyme and pathway databases

SignaLinki O45539.

Miscellaneous databases

NextBioi 879039.

Gene expression databases

ExpressionAtlasi O45539. baseline.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO45539_CAEEL
AccessioniPrimary (citable) accession number: O45539
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3