Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-specific protein-tyrosine kinase

Gene

src-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO45539.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific protein-tyrosine kinaseSAAS annotation (EC:2.7.10.2SAAS annotation)
Gene namesi
Name:src-2Imported
ORF Names:CELE_F49B2.5Imported, F49B2.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF49B2.5; CE24991; WBGene00005078; src-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiO45539. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-26743N.
IntActiO45539. 43 interactions.
MINTiMINT-117088.

Structurei

3D structure databases

ProteinModelPortaliO45539.
SMRiO45539. Positions 62-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation
Contains SH2 domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
InParanoidiO45539.
KOiK08892.
OMAiMGGHKSK.
OrthoDBiEOG7GTT2V.
PhylomeDBiO45539.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCIGKEDP PPGATSPVHT SSTLGRESLP SHPRIPSIGP IAASSSGNTI
60 70 80 90 100
DKNQNISQSA NFVALFQYDA RTDDDLSFKK DDILEILNDT QGDWWFARHK
110 120 130 140 150
ATGRTGYIPS NYVAREKSIE SQPWYFGKMR RIDAEKCLLH TLNEHGAFLV
160 170 180 190 200
RDSESRQHDL SLSVRENDSV KHYRIRQLDH GGYFIARRRP FATLHDLIAH
210 220 230 240 250
YQREADGLCV NLGAPCAKSE APQTTTFTYD DQWEVDRRSV RLIRQIGAGQ
260 270 280 290 300
FGEVWEGRWN VNVPVAVKKL KAGTADPTDF LAEAQIMKKL RHPKLLSLYA
310 320 330 340 350
VCTRDEPILI VTELMQENLL TFLQRRGRQC QMPQLVEISA QVAAGMAYLE
360 370 380 390 400
EMNFIHRDLA ARNILINNSL SVKIADFGLA RILMKENEYE ARTGARFPIK
410 420 430 440 450
WTAPEAANYN RFTTKSDVWS FGILLTEIVT FGRLPYPGMT NAEVLQQVDA
460 470 480 490 500
GYRMPCPAGC PVTLYDIMQQ CWRSDPDKRP TFETLQWKLE DLFNLDSSEY

KEASINF
Length:507
Mass (Da):57,530
Last modified:May 1, 2000 - v2
Checksum:iCD3DC68FC91ED86D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04427.2.
PIRiT22405.
RefSeqiNP_493502.1. NM_061101.4.
UniGeneiCel.18455.

Genome annotation databases

EnsemblMetazoaiF49B2.5; F49B2.5; WBGene00005078.
GeneIDi173296.
KEGGicel:CELE_F49B2.5.
UCSCiF49B2.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04427.2.
PIRiT22405.
RefSeqiNP_493502.1. NM_061101.4.
UniGeneiCel.18455.

3D structure databases

ProteinModelPortaliO45539.
SMRiO45539. Positions 62-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26743N.
IntActiO45539. 43 interactions.
MINTiMINT-117088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF49B2.5; F49B2.5; WBGene00005078.
GeneIDi173296.
KEGGicel:CELE_F49B2.5.
UCSCiF49B2.5. c. elegans.

Organism-specific databases

CTDi173296.
WormBaseiF49B2.5; CE24991; WBGene00005078; src-2.

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
InParanoidiO45539.
KOiK08892.
OMAiMGGHKSK.
OrthoDBiEOG7GTT2V.
PhylomeDBiO45539.

Enzyme and pathway databases

SignaLinkiO45539.

Miscellaneous databases

NextBioi879039.

Gene expression databases

ExpressionAtlasiO45539. baseline and differential.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO45539_CAEEL
AccessioniPrimary (citable) accession number: O45539
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.