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Protein

Regulator of G-protein signaling rgs-10

Gene

rgs-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Shown to have a role in viability and embryogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB-KW
  • reproduction Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling rgs-10
Gene namesi
Name:rgs-10
ORF Names:F45B8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF45B8.2; CE10430; WBGene00004353; rgs-10.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Sterility and embryonic lethality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002235751 – 270Regulator of G-protein signaling rgs-10Add BLAST270

Proteomic databases

PaxDbiO45523.
PRIDEiO45523.

Expressioni

Gene expression databases

BgeeiWBGene00004353.

Interactioni

Protein-protein interaction databases

STRINGi6239.F45B8.2.

Structurei

3D structure databases

ProteinModelPortaliO45523.
SMRiO45523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 252RGSPROSITE-ProRule annotationAdd BLAST118

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00530000065130.
HOGENOMiHOG000153585.
InParanoidiO45523.
OMAiRRIFDEY.
PhylomeDBiO45523.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiView protein in InterPro
IPR016137. RGS.
IPR024066. RGS_subdom1.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

O45523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAVFSPCD VASKLLSEVV GEKYPKVDDD DSIVEPVTSL CLPQLSYEDF
60 70 80 90 100
HHFSVIPLWN KTFPCRLATE WNPKNKKDAP PKKKNALVIL ERVASRSNQN
110 120 130 140 150
AVSRVINILR SKVHLMFSSS NELPSSEDVE RWKKSPETLA ASEYGCNLFI
160 170 180 190 200
QFLKEQTSEN EVDFWLDCQK FRSSKMSSRQ NEARRIFDEY FAMGSPKKIY
210 220 230 240 250
IERYLWCVVQ AYLVNDPGWR HTFDVAQAYV GLKLAKKSHK KFLEDPLYLD
260 270
LVELVTSGVN YNKFWHDKLE
Length:270
Mass (Da):31,286
Last modified:June 1, 1998 - v1
Checksum:i9C36042F7A94F5A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83227 Genomic DNA. Translation: CAB05727.1.
PIRiT22213.
RefSeqiNP_510482.1. NM_078081.1.
UniGeneiCel.1012.

Genome annotation databases

EnsemblMetazoaiF45B8.2; F45B8.2; WBGene00004353.
GeneIDi185764.
KEGGicel:CELE_F45B8.2.
UCSCiF45B8.2. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRGS10_CAEEL
AccessioniPrimary (citable) accession number: O45523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: June 1, 1998
Last modified: February 15, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase