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Protein

Regulator of G-protein signaling rgs-10

Gene

rgs-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Shown to have a role in viability and embryogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB-KW
  • reproduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling rgs-10
Gene namesi
Name:rgs-10
ORF Names:F45B8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF45B8.2; CE10430; WBGene00004353; rgs-10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Sterility and embryonic lethality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Regulator of G-protein signaling rgs-10PRO_0000223575Add
BLAST

Proteomic databases

PaxDbiO45523.

Interactioni

Protein-protein interaction databases

STRINGi6239.F45B8.2.

Structurei

3D structure databases

ProteinModelPortaliO45523.
SMRiO45523. Positions 126-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 252118RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00530000065130.
HOGENOMiHOG000153585.
InParanoidiO45523.
OMAiRRIFDEY.
PhylomeDBiO45523.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAVFSPCD VASKLLSEVV GEKYPKVDDD DSIVEPVTSL CLPQLSYEDF
60 70 80 90 100
HHFSVIPLWN KTFPCRLATE WNPKNKKDAP PKKKNALVIL ERVASRSNQN
110 120 130 140 150
AVSRVINILR SKVHLMFSSS NELPSSEDVE RWKKSPETLA ASEYGCNLFI
160 170 180 190 200
QFLKEQTSEN EVDFWLDCQK FRSSKMSSRQ NEARRIFDEY FAMGSPKKIY
210 220 230 240 250
IERYLWCVVQ AYLVNDPGWR HTFDVAQAYV GLKLAKKSHK KFLEDPLYLD
260 270
LVELVTSGVN YNKFWHDKLE
Length:270
Mass (Da):31,286
Last modified:June 1, 1998 - v1
Checksum:i9C36042F7A94F5A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83227 Genomic DNA. Translation: CAB05727.1.
PIRiT22213.
RefSeqiNP_510482.1. NM_078081.1.
UniGeneiCel.1012.

Genome annotation databases

EnsemblMetazoaiF45B8.2; F45B8.2; WBGene00004353.
GeneIDi185764.
KEGGicel:CELE_F45B8.2.
UCSCiF45B8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83227 Genomic DNA. Translation: CAB05727.1.
PIRiT22213.
RefSeqiNP_510482.1. NM_078081.1.
UniGeneiCel.1012.

3D structure databases

ProteinModelPortaliO45523.
SMRiO45523. Positions 126-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F45B8.2.

Proteomic databases

PaxDbiO45523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF45B8.2; F45B8.2; WBGene00004353.
GeneIDi185764.
KEGGicel:CELE_F45B8.2.
UCSCiF45B8.2. c. elegans.

Organism-specific databases

CTDi185764.
WormBaseiF45B8.2; CE10430; WBGene00004353; rgs-10.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00530000065130.
HOGENOMiHOG000153585.
InParanoidiO45523.
OMAiRRIFDEY.
PhylomeDBiO45523.

Miscellaneous databases

PROiO45523.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones."
    Fernandez A.G., Gunsalus K.C., Huang J., Chuang L.S., Ying N., Liang H.L., Tang C., Schetter A.J., Zegar C., Rual J.F., Hill D.E., Reinke V., Vidal M., Piano F.
    Genome Res. 15:250-259(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRGS10_CAEEL
AccessioniPrimary (citable) accession number: O45523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.