Reviewed, UniProtKB/Swiss-Prot O45521 (NH111_CAEEL)

Names and origin

Protein names

Recommended name:
    Nuclear hormone receptor family member nhr-111

Gene names

Name:	nhr-111
ORF Names:	F44G3.9

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Orphan nuclear receptor.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-313236,EBI-313236
	O17835	1	EBI-313236,EBI-320466
	O18051	1	EBI-313236,EBI-319712
	O18302	1	EBI-313236,EBI-312747
	O45603	1	EBI-313236,EBI-313357
	Q18266	1	EBI-313236,EBI-322401
	Q20198	1	EBI-313236,EBI-316812
	Q22174	1	EBI-313236,EBI-311938
	Q86ME1	1	EBI-313236,EBI-322422
	Q95XM4	1	EBI-313236,EBI-331636
	Q9N582	1	EBI-313236,EBI-315836
	Q9N5S5	1	EBI-313236,EBI-314326
	Q9U1X3	1	EBI-313236,EBI-315967
	Q9XVA3	1	EBI-313236,EBI-319064
	Q9XWQ9	1	EBI-313236,EBI-322529
bir-1	Q22837	1	EBI-313236,EBI-328435
gad-1	O16519	1	EBI-313236,EBI-327317
gei-4	Q9TZ38	1	EBI-313236,EBI-329192
gst-19	Q93701	1	EBI-313236,EBI-321323
let-413	O61967	1	EBI-313236,EBI-320515
ncl-1	P34611	1	EBI-313236,EBI-322560
ntl-2	Q10923	1	EBI-313236,EBI-313231
pdr-1	Q9XUS3	1	EBI-313236,EBI-322485
rpa-2	Q95Y97	1	EBI-313236,EBI-325404
scrm-1	O45799	1	EBI-313236,EBI-312683
sdz-38	Q09620	1	EBI-313236,EBI-332504
spd-5	P91349	1	EBI-313236,EBI-322479
unc-44	Q17490	1	EBI-313236,EBI-322367
vab-3	Q17359	1	EBI-313236,EBI-319610
ztf-4	Q9TZI2	1	EBI-313236,EBI-322494

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Nuclear hormone receptor family member nhr-111		PRO_0000223589
Regions
	DNA binding	39 – 115	77	Nuclear receptor
	Zinc finger	42 – 62	21	NR C4-type
	Zinc finger	78 – 98	21	NR C4-type

Sequences

	Sequence		Length	Mass (Da)
	O45521-1 [UniParc]. Last modified July 5, 2004. Version 2. Checksum: 3F54D39BA3732AA2	FASTA	311	35,145
	10 20 30 40 50 60 MSSQNAKSIG GILETSTVPL VIQPQIVNDP AQNNITLPIT LCAVCGDTSN GNHYGVPTCF 70 80 90 100 110 120 GCSGFFRRTV RNKLVHGCWN GDGNCVIDKA NRNRCKSCRI KKCFKKGMNK NAVQPERTSH 130 140 150 160 170 180 SYTVEYVELP SFREYSKGLL PTHSDRLRFQ HEHAQHEIDT SSVLVHLKNA LQWVQQFSLF 190 200 210 220 230 240 AVLSDVEKSQ IILTQWPHLL CLALFENSEK IFIDEKFAQL AEKFKSLELS AQDYFLLKGI 250 260 270 280 290 300 IIFTETKDGT DLKFDRQLDI CIGLLNQLHL ESSKSKSGRL LFLLGELKSY STRQLESLLD 310 LKACEIVISF L

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z83109 Genomic DNA. Translation: CAB05521.2.
PIR	T22203.
RefSeq	NP_507060.2.
UniGene	Cel.3575
3D structure databases
HSSP	HSSP built from PDB template 2NLL based on UniProtKB P19793.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:26766N.
IntAct	O45521. 68 interactions.
Genome annotation databases
Ensembl	F44G3.9. Caenorhabditis elegans. [Contig view]
GeneID	185757.
KEGG	cel:F44G3.9.
NMPDR	fig|6239.3.peg.21137.
Organism-specific databases
WormBase	WBGene00003701. nhr-111.
WormPep	F44G3.9. CE35538. [WorfDB]
Phylogenomic databases
OMA	O45521. LAYEVEM.
Gene expression databases
ArrayExpress	O45521.
Family and domain databases
InterPro	IPR001723. Str_hrmn_rcpt. IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER. PR00350. VITAMINDR.
ProDom	PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	929390.

Entry information

Entry name

NH111_CAEEL

Accession

Primary (citable) accession number: O45521

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project