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Protein

Echinoderm microtubule-associated protein-like elp-1

Gene

elp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

Enzyme and pathway databases

SignaLinkiO45487.

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like elp-1
Gene namesi
Name:elp-1
ORF Names:F38A6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF38A6.2a; CE15999; WBGene00001248; elp-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • dendrite Source: WormBase
  • microtubule Source: UniProtKB-KW
  • neuromuscular junction Source: WormBase
  • neuronal cell body Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 891891Echinoderm microtubule-associated protein-like elp-1PRO_0000050966Add
BLAST

Proteomic databases

PaxDbiO45487.

Expressioni

Gene expression databases

BgeeiWBGene00001248.
ExpressionAtlasiO45487. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.F38A6.2a.

Structurei

3D structure databases

ProteinModelPortaliO45487.
SMRiO45487. Positions 240-888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati330 – 40172WD 1Add
BLAST
Repeati404 – 44744WD 2Add
BLAST
Repeati499 – 53739WD 3Add
BLAST
Repeati541 – 57939WD 4Add
BLAST
Repeati626 – 66439WD 5Add
BLAST
Repeati708 – 74740WD 6Add
BLAST
Repeati753 – 79240WD 7Add
BLAST
Repeati816 – 85338WD 8Add
BLAST
Repeati859 – 89032WD 9Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated
Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000017827.
InParanoidiO45487.
KOiK18595.
OMAiEMEHTEA.
OrthoDBiEOG091G02HZ.
PhylomeDBiO45487.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISNGWSSS SIISDVLPEE EFEEVEEDEL ILNENDRLKF RVDELEKIVV
60 70 80 90 100
AQRNEILLLQ SSTVEILRRL QNLEIQDQSR SPTCSGYSSL PRRISGSKSS
110 120 130 140 150
YTMSPSHAPP RSSHANSKSL YINGMNNNSE EVSPGPPRHR PPTRGSDGMV
160 170 180 190 200
NVSVGKSARG SPMRKWVSTH DMKDTDRFRR LSTSSEASTS ATMNPIVNSV
210 220 230 240 250
RRLSTTHRQS SPSLLSLCSV ISRSPSTSSI LRKNNRTCQF SNGSGHLPIF
260 270 280 290 300
IGGKTVQVPV PTGYENMDPT MDQDPPTMKV TLKHVYSYRG KDVRSNIEML
310 320 330 340 350
PTGELVFFSA NLVVLMNITG EDRSQRIYHG HTCDVKCITL HPNKILVASG
360 370 380 390 400
QSSCHSVEKF QKPEHTSPID SPEDLVRQLE MEHTEAHVRI WDTIKLTTLM
410 420 430 440 450
VLNGFEKGIC HVAFSKTDSG SLLAVVDDSL KHLMSVWNWQ KGKREGEVKA
460 470 480 490 500
SNDVVFECKW HPTIRNLIVL YGKGHFSFFN YDPATGVLVK TVATFEGRDK
510 520 530 540 550
PKTVLSMCFG ENDQVVTGDS NGTISIWDPR TCKTTKQAHS VHPGGVYSLT
560 570 580 590 600
LAKSGKILSG GKDRMVSEWD LQDLVRTRRP IELPDEKGFP RVILQNGSEL
610 620 630 640 650
IIGTSSNTLL FGNIENSTNL TSLIEGDPGN LTFLLTCSSN QLITSSQCGT
660 670 680 690 700
LRIWNHIDKK VEFSKKFIDS VECVDVDVTN THIILGFAAG LWIVMNITKQ
710 720 730 740 750
QTIQEKKEGT APITAVKFAP SGATFAVATK DPHLTIYRID ASKNLLVIAR
760 770 780 790 800
IHHIPAPIVA LDFSSDSQYL RGQSIGAHLL FWTKAGEICD GTSVKDVKWG
810 820 830 840 850
SSRVKIGFET ALVAHSSNGQ VTAVAQCEDI SACGMENGTI RIYKNPVTSV
860 870 880 890
TAGFVELLGH GRIIKSVAFS NKIQLFSCSP TDNSVFEWCL E
Length:891
Mass (Da):98,372
Last modified:June 1, 1998 - v1
Checksum:iA8EFC84FA6FCE852
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92833 Genomic DNA. Translation: CAB07379.1.
PIRiT21942.
RefSeqiNP_001256950.1. NM_001270021.1.
UniGeneiCel.4267.

Genome annotation databases

EnsemblMetazoaiF38A6.2a; F38A6.2a; WBGene00001248.
GeneIDi180358.
KEGGicel:CELE_F38A6.2.
UCSCiF38A6.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92833 Genomic DNA. Translation: CAB07379.1.
PIRiT21942.
RefSeqiNP_001256950.1. NM_001270021.1.
UniGeneiCel.4267.

3D structure databases

ProteinModelPortaliO45487.
SMRiO45487. Positions 240-888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F38A6.2a.

Proteomic databases

PaxDbiO45487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF38A6.2a; F38A6.2a; WBGene00001248.
GeneIDi180358.
KEGGicel:CELE_F38A6.2.
UCSCiF38A6.2. c. elegans.

Organism-specific databases

CTDi180358.
WormBaseiF38A6.2a; CE15999; WBGene00001248; elp-1.

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000017827.
InParanoidiO45487.
KOiK18595.
OMAiEMEHTEA.
OrthoDBiEOG091G02HZ.
PhylomeDBiO45487.

Enzyme and pathway databases

SignaLinkiO45487.

Miscellaneous databases

PROiO45487.

Gene expression databases

BgeeiWBGene00001248.
ExpressionAtlasiO45487. baseline.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMAL_CAEEL
AccessioniPrimary (citable) accession number: O45487
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.