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Protein

Nuclear hormone receptor family member nhr-54

Gene

nhr-54

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi14 – 9279Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri17 – 3721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 8028NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-54
Gene namesi
Name:nhr-54
ORF Names:F36D3.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF36D3.2; CE15966; WBGene00003644; nhr-54.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Nuclear hormone receptor family member nhr-54PRO_0000053788Add
BLAST

Proteomic databases

PaxDbiO45460.

Interactioni

Protein-protein interaction databases

STRINGi6239.F36D3.2.

Structurei

3D structure databases

ProteinModelPortaliO45460.
SMRiO45460. Positions 14-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 3721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 8028NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00820000127229.
HOGENOMiHOG000018997.
InParanoidiO45460.
OrthoDBiEOG7Q5HJ3.
PhylomeDBiO45460.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPSTSSEM TYFSVKCAIC YKAGHGQHFG VETCRACAAF FRRTVVLNRK
60 70 80 90 100
YKCTRKSGKC KIGSDETKDV MCKFCRFKKC IDLGMTTENV RTDQVINLNV
110 120 130 140 150
EPSTSQSLVR LEMTSLQPET DDSNRVQYQI IHPRTRGPAI LIDVNAIIKR
160 170 180 190 200
SKTILETHFF PDDDVIVELN PLEKMTFCLR KLRSKQSWNP NFFTKINFLD
210 220 230 240 250
LFEFWESQME DTATWLMYSG EFRKLPNHEK IAIFKIVWAV WRRLERYTMT
260 270 280 290 300
AQVFGQKCYD EQILLHSHQD AARFTDYDVD YSYITDQGFE KINGLFGGKM
310 320 330 340 350
IQYFDIIVKP YLELELSDTE IAYILCQIVW NYAGRRLQGQ TQAAGERFLE
360 370 380 390 400
VISNNLHKYY EDKSGNRKRA EDKQNYVARL AKMMQIVNQM LNAQLKMENT
410 420
MDVAMLFNTF NIVFTEPEFF RV
Length:422
Mass (Da):49,473
Last modified:June 1, 1998 - v1
Checksum:i3B652E904C86C9AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81531 Genomic DNA. Translation: CAB04316.1.
AF273800 mRNA. Translation: AAG15149.1.
PIRiT21850.
RefSeqiNP_507179.3. NM_074778.4.
UniGeneiCel.2940.

Genome annotation databases

EnsemblMetazoaiF36D3.2; F36D3.2; WBGene00003644.
GeneIDi180106.
KEGGicel:CELE_F36D3.2.
UCSCiF36D3.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81531 Genomic DNA. Translation: CAB04316.1.
AF273800 mRNA. Translation: AAG15149.1.
PIRiT21850.
RefSeqiNP_507179.3. NM_074778.4.
UniGeneiCel.2940.

3D structure databases

ProteinModelPortaliO45460.
SMRiO45460. Positions 14-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F36D3.2.

Proteomic databases

PaxDbiO45460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF36D3.2; F36D3.2; WBGene00003644.
GeneIDi180106.
KEGGicel:CELE_F36D3.2.
UCSCiF36D3.2. c. elegans.

Organism-specific databases

CTDi180106.
WormBaseiF36D3.2; CE15966; WBGene00003644; nhr-54.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00820000127229.
HOGENOMiHOG000018997.
InParanoidiO45460.
OrthoDBiEOG7Q5HJ3.
PhylomeDBiO45460.

Miscellaneous databases

NextBioi908108.
PROiO45460.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes."
    Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.
    J. Mol. Evol. 60:577-586(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-422.

Entry informationi

Entry nameiNHR54_CAEEL
AccessioniPrimary (citable) accession number: O45460
Secondary accession number(s): Q9GTF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 1998
Last modified: December 9, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.