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Protein

Nuclear hormone receptor family member nhr-4

Gene

nhr-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 122Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri50 – 70NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri86 – 110NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-4
Gene namesi
Name:nhr-4
ORF Names:F32B6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF32B6.1 ; CE24934 ; WBGene00003603 ; nhr-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537581 – 492Nuclear hormone receptor family member nhr-4Add BLAST492

Proteomic databases

EPDiO45436
PaxDbiO45436
PRIDEiO45436

Expressioni

Gene expression databases

BgeeiWBGene00003603

Interactioni

Protein-protein interaction databases

BioGridi42943, 3 interactors
DIPiDIP-25524N
IntActiO45436, 9 interactors
STRINGi6239.F32B6.1

Structurei

3D structure databases

ProteinModelPortaliO45436
SMRiO45436
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 481NR LBDPROSITE-ProRule annotationAdd BLAST267

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 70NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri86 – 110NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2808 Eukaryota
ENOG410XR90 LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000017160
InParanoidiO45436
OMAiDVAFGKH
OrthoDBiEOG091G0664
PhylomeDBiO45436

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O45436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNERGMLVDP RFDAFFKLEQ IDDYKYDGAD TSPSTSNGLP ETSNGGRLIC
60 70 80 90 100
DVCGDVAFGK HYGINACNGC KGFFRRSVWS RRQYSCRFGG DCPVVKEHRN
110 120 130 140 150
VCRSCRLKKC FEVGMNPDSV QNERDRNAKN GGMGGPMSSP TQSSLCKELT
160 170 180 190 200
ISNGQIKRKR LRPETVEKTT QTDGKLEIND DFDFENMQQN PTPPGLLPLK
210 220 230 240 250
IERISTPPSD LPVPMDFSIH SAVLDIEQKV FYNCPVAVDN SINATKTPIT
260 270 280 290 300
LPFEVVFRQP HLVCNRYPMR FSNTRVLTPE DLIDGWRRHF TYYSDWCHAM
310 320 330 340 350
DEFKALSPED QIVLAKKKII LHGWLVHAYY SYKSGCNGIC FANGAAHLPE
360 370 380 390 400
GGHPSITEFY KECMPRYLNY VIYPMHNFQM DDAEMVLIKC IMFFSSESGL
410 420 430 440 450
SAAGRQIVSA AREKYLSALY NYGRANKCTT SAQATLRIAK FMIMLSAITS
460 470 480 490
LTHLMNEGVH VTSLFNIIEF DELIQATHKT TPPQHSPPAP MG
Length:492
Mass (Da):55,465
Last modified:May 1, 2000 - v2
Checksum:iCB191A1112225F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083223 mRNA Translation: AAD03681.1
Z81074 Genomic DNA Translation: CAB03044.2
PIRiT21645
T43346
RefSeqiNP_501775.1, NM_069374.8
UniGeneiCel.19600

Genome annotation databases

EnsemblMetazoaiF32B6.1; F32B6.1; WBGene00003603
GeneIDi177839
KEGGicel:CELE_F32B6.1
UCSCiF32B6.1.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNHR4_CAEEL
AccessioniPrimary (citable) accession number: O45436
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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