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Protein

Nuclear hormone receptor family member nhr-4

Gene

nhr-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 122Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri50 – 70NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri86 – 110NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-4
Gene namesi
Name:nhr-4
ORF Names:F32B6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF32B6.1; CE24934; WBGene00003603; nhr-4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537581 – 492Nuclear hormone receptor family member nhr-4Add BLAST492

Proteomic databases

PaxDbiO45436.
PRIDEiO45436.

Expressioni

Gene expression databases

BgeeiWBGene00003603.

Interactioni

Protein-protein interaction databases

BioGridi42943. 3 interactors.
DIPiDIP-25524N.
IntActiO45436. 9 interactors.
MINTiMINT-1120817.
STRINGi6239.F32B6.1.

Structurei

3D structure databases

ProteinModelPortaliO45436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 70NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri86 – 110NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2808. Eukaryota.
ENOG410XR90. LUCA.
GeneTreeiENSGT00880000138101.
HOGENOMiHOG000017160.
InParanoidiO45436.
OMAiDVAFGKH.
OrthoDBiEOG091G0664.
PhylomeDBiO45436.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O45436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNERGMLVDP RFDAFFKLEQ IDDYKYDGAD TSPSTSNGLP ETSNGGRLIC
60 70 80 90 100
DVCGDVAFGK HYGINACNGC KGFFRRSVWS RRQYSCRFGG DCPVVKEHRN
110 120 130 140 150
VCRSCRLKKC FEVGMNPDSV QNERDRNAKN GGMGGPMSSP TQSSLCKELT
160 170 180 190 200
ISNGQIKRKR LRPETVEKTT QTDGKLEIND DFDFENMQQN PTPPGLLPLK
210 220 230 240 250
IERISTPPSD LPVPMDFSIH SAVLDIEQKV FYNCPVAVDN SINATKTPIT
260 270 280 290 300
LPFEVVFRQP HLVCNRYPMR FSNTRVLTPE DLIDGWRRHF TYYSDWCHAM
310 320 330 340 350
DEFKALSPED QIVLAKKKII LHGWLVHAYY SYKSGCNGIC FANGAAHLPE
360 370 380 390 400
GGHPSITEFY KECMPRYLNY VIYPMHNFQM DDAEMVLIKC IMFFSSESGL
410 420 430 440 450
SAAGRQIVSA AREKYLSALY NYGRANKCTT SAQATLRIAK FMIMLSAITS
460 470 480 490
LTHLMNEGVH VTSLFNIIEF DELIQATHKT TPPQHSPPAP MG
Length:492
Mass (Da):55,465
Last modified:May 1, 2000 - v2
Checksum:iCB191A1112225F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083223 mRNA. Translation: AAD03681.1.
Z81074 Genomic DNA. Translation: CAB03044.2.
PIRiT21645.
T43346.
RefSeqiNP_501775.1. NM_069374.8.
UniGeneiCel.19600.

Genome annotation databases

EnsemblMetazoaiF32B6.1; F32B6.1; WBGene00003603.
GeneIDi177839.
KEGGicel:CELE_F32B6.1.
UCSCiF32B6.1.2. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNHR4_CAEEL
AccessioniPrimary (citable) accession number: O45436
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families