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Protein

Nuclear hormone receptor family member nhr-4

Gene

nhr-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 12276Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri50 – 7021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri86 – 11025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-4
Gene namesi
Name:nhr-4
ORF Names:F32B6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF32B6.1; CE24934; WBGene00003603; nhr-4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Nuclear hormone receptor family member nhr-4PRO_0000053758Add
BLAST

Proteomic databases

PaxDbiO45436.
PRIDEiO45436.

Interactioni

Protein-protein interaction databases

BioGridi42943. 3 interactions.
DIPiDIP-25524N.
IntActiO45436. 9 interactions.
MINTiMINT-1120817.
STRINGi6239.F32B6.1.

Structurei

3D structure databases

ProteinModelPortaliO45436.
SMRiO45436. Positions 49-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 7021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri86 – 11025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2808. Eukaryota.
ENOG410XR90. LUCA.
GeneTreeiENSGT00840000130053.
HOGENOMiHOG000017160.
InParanoidiO45436.
OMAiDVAFGKH.
OrthoDBiEOG7N37HC.
PhylomeDBiO45436.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNERGMLVDP RFDAFFKLEQ IDDYKYDGAD TSPSTSNGLP ETSNGGRLIC
60 70 80 90 100
DVCGDVAFGK HYGINACNGC KGFFRRSVWS RRQYSCRFGG DCPVVKEHRN
110 120 130 140 150
VCRSCRLKKC FEVGMNPDSV QNERDRNAKN GGMGGPMSSP TQSSLCKELT
160 170 180 190 200
ISNGQIKRKR LRPETVEKTT QTDGKLEIND DFDFENMQQN PTPPGLLPLK
210 220 230 240 250
IERISTPPSD LPVPMDFSIH SAVLDIEQKV FYNCPVAVDN SINATKTPIT
260 270 280 290 300
LPFEVVFRQP HLVCNRYPMR FSNTRVLTPE DLIDGWRRHF TYYSDWCHAM
310 320 330 340 350
DEFKALSPED QIVLAKKKII LHGWLVHAYY SYKSGCNGIC FANGAAHLPE
360 370 380 390 400
GGHPSITEFY KECMPRYLNY VIYPMHNFQM DDAEMVLIKC IMFFSSESGL
410 420 430 440 450
SAAGRQIVSA AREKYLSALY NYGRANKCTT SAQATLRIAK FMIMLSAITS
460 470 480 490
LTHLMNEGVH VTSLFNIIEF DELIQATHKT TPPQHSPPAP MG
Length:492
Mass (Da):55,465
Last modified:May 1, 2000 - v2
Checksum:iCB191A1112225F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083223 mRNA. Translation: AAD03681.1.
Z81074 Genomic DNA. Translation: CAB03044.2.
PIRiT21645.
T43346.
RefSeqiNP_501775.1. NM_069374.8.
UniGeneiCel.19600.

Genome annotation databases

EnsemblMetazoaiF32B6.1; F32B6.1; WBGene00003603.
GeneIDi177839.
KEGGicel:CELE_F32B6.1.
UCSCiF32B6.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083223 mRNA. Translation: AAD03681.1.
Z81074 Genomic DNA. Translation: CAB03044.2.
PIRiT21645.
T43346.
RefSeqiNP_501775.1. NM_069374.8.
UniGeneiCel.19600.

3D structure databases

ProteinModelPortaliO45436.
SMRiO45436. Positions 49-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42943. 3 interactions.
DIPiDIP-25524N.
IntActiO45436. 9 interactions.
MINTiMINT-1120817.
STRINGi6239.F32B6.1.

Proteomic databases

PaxDbiO45436.
PRIDEiO45436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32B6.1; F32B6.1; WBGene00003603.
GeneIDi177839.
KEGGicel:CELE_F32B6.1.
UCSCiF32B6.1.2. c. elegans.

Organism-specific databases

CTDi177839.
WormBaseiF32B6.1; CE24934; WBGene00003603; nhr-4.

Phylogenomic databases

eggNOGiKOG2808. Eukaryota.
ENOG410XR90. LUCA.
GeneTreeiENSGT00840000130053.
HOGENOMiHOG000017160.
InParanoidiO45436.
OMAiDVAFGKH.
OrthoDBiEOG7N37HC.
PhylomeDBiO45436.

Miscellaneous databases

PROiO45436.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes."
    Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.
    Genome Res. 9:103-120(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiNHR4_CAEEL
AccessioniPrimary (citable) accession number: O45436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.