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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-35

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-35Imported
ORF Names:CELE_F31D4.7Imported, F31D4.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF31D4.7; CE44736; WBGene00006687; twk-35.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei241 – 260HelicalSequence analysisAdd BLAST20
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei371 – 388HelicalSequence analysisAdd BLAST18
Transmembranei394 – 416HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO45422.

Expressioni

Gene expression databases

BgeeiWBGene00006687.

Interactioni

Protein-protein interaction databases

STRINGi6239.F31D4.7.

Structurei

3D structure databases

ProteinModelPortaliO45422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 293Ion_trans_2InterPro annotationAdd BLAST60
Domaini347 – 420Ion_trans_2InterPro annotationAdd BLAST74

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000017820.
InParanoidiO45422.
KOiK05323.
OMAiAGTICTT.
OrthoDBiEOG091G055B.
PhylomeDBiO45422.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

O45422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSHGEHRQ SFKQKRAEEK RRWSSSGSHH QPQAKQSLAV LAQLMLPALI
60 70 80 90 100
EEHTAQQEDV VVPTHYKADG SLSRTASNRR HVFQSVNLLQ RANGQMRKGA
110 120 130 140 150
AGVWDIAGRA HLAGKRKVEQ LQQKPPLWLV ILNQAYHKYG LKHAVLIIVF
160 170 180 190 200
LIYCISGGLV FWLIEEPYQS ELRDAWQHKI ENNRTARVDA MMKKIFNNSD
210 220 230 240 250
YLIYIKGNTS QRLTTFFIEE LGSYENQLGV KWSQQKMDWD FWNAVLFAGT
260 270 280 290 300
ICTTIGYGHI YPMTDAGRML TMIFALFGIP LMLLVLQDFG KLLTITMKFP
310 320 330 340 350
WFQTKRLMRR IMRCCTKQPI EEMKEIERQE RHDLDIFDLP LPVGIALIVT
360 370 380 390 400
WIFICSFVLS VWDHNWTLLE SFYFFFTSLS TVGLGDLVPS SPRLLITMFG
410 420 430 440 450
FILVGLSLVS MVINLLQAKM KSTYEAGRND EKTPHIHQTL PTSLGVLQCF
460 470 480 490 500
SPDEEKKTDY SERSLSRSTQ TSLSLPGVRQ VVLRSDGVHW VNTDTSSPTK
510 520 530 540 550
SPDEVTNLVE YETALRVCEQ IGDNNNEEFS EAESLICETE VLLEVGECLS

DLEEFLA
Length:557
Mass (Da):63,732
Last modified:June 15, 2010 - v3
Checksum:i9522492E61DF3633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07375.3.
RefSeqiNP_508031.3. NM_075630.3.
UniGeneiCel.26653.

Genome annotation databases

EnsemblMetazoaiF31D4.7; F31D4.7; WBGene00006687.
GeneIDi185149.
KEGGicel:CELE_F31D4.7.
UCSCiF31D4.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07375.3.
RefSeqiNP_508031.3. NM_075630.3.
UniGeneiCel.26653.

3D structure databases

ProteinModelPortaliO45422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F31D4.7.

Proteomic databases

PaxDbiO45422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF31D4.7; F31D4.7; WBGene00006687.
GeneIDi185149.
KEGGicel:CELE_F31D4.7.
UCSCiF31D4.7. c. elegans.

Organism-specific databases

CTDi185149.
WormBaseiF31D4.7; CE44736; WBGene00006687; twk-35.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000017820.
InParanoidiO45422.
KOiK05323.
OMAiAGTICTT.
OrthoDBiEOG091G055B.
PhylomeDBiO45422.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Gene expression databases

BgeeiWBGene00006687.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Entry informationi

Entry nameiO45422_CAEEL
AccessioniPrimary (citable) accession number: O45422
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.