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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-35

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344 TWIK-related spinal cord K+ channel (TRESK)
R-CEL-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-35Imported
ORF Names:CELE_F31D4.7Imported, F31D4.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF31D4.7 ; CE44736 ; WBGene00006687 ; twk-35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei241 – 260HelicalSequence analysisAdd BLAST20
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei371 – 388HelicalSequence analysisAdd BLAST18
Transmembranei394 – 416HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO45422

Expressioni

Gene expression databases

BgeeiWBGene00006687

Interactioni

Protein-protein interaction databases

STRINGi6239.F31D4.7

Structurei

3D structure databases

ProteinModelPortaliO45422
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 293Ion_trans_2InterPro annotationAdd BLAST60
Domaini347 – 420Ion_trans_2InterPro annotationAdd BLAST74

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00700000104522
HOGENOMiHOG000017820
InParanoidiO45422
KOiK05323
OMAiLTITMKF
OrthoDBiEOG091G055B
PhylomeDBiO45422

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL

Sequencei

Sequence statusi: Complete.

O45422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSHGEHRQ SFKQKRAEEK RRWSSSGSHH QPQAKQSLAV LAQLMLPALI
60 70 80 90 100
EEHTAQQEDV VVPTHYKADG SLSRTASNRR HVFQSVNLLQ RANGQMRKGA
110 120 130 140 150
AGVWDIAGRA HLAGKRKVEQ LQQKPPLWLV ILNQAYHKYG LKHAVLIIVF
160 170 180 190 200
LIYCISGGLV FWLIEEPYQS ELRDAWQHKI ENNRTARVDA MMKKIFNNSD
210 220 230 240 250
YLIYIKGNTS QRLTTFFIEE LGSYENQLGV KWSQQKMDWD FWNAVLFAGT
260 270 280 290 300
ICTTIGYGHI YPMTDAGRML TMIFALFGIP LMLLVLQDFG KLLTITMKFP
310 320 330 340 350
WFQTKRLMRR IMRCCTKQPI EEMKEIERQE RHDLDIFDLP LPVGIALIVT
360 370 380 390 400
WIFICSFVLS VWDHNWTLLE SFYFFFTSLS TVGLGDLVPS SPRLLITMFG
410 420 430 440 450
FILVGLSLVS MVINLLQAKM KSTYEAGRND EKTPHIHQTL PTSLGVLQCF
460 470 480 490 500
SPDEEKKTDY SERSLSRSTQ TSLSLPGVRQ VVLRSDGVHW VNTDTSSPTK
510 520 530 540 550
SPDEVTNLVE YETALRVCEQ IGDNNNEEFS EAESLICETE VLLEVGECLS

DLEEFLA
Length:557
Mass (Da):63,732
Last modified:June 15, 2010 - v3
Checksum:i9522492E61DF3633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB07375.3
RefSeqiNP_508031.3, NM_075630.3
UniGeneiCel.26653

Genome annotation databases

EnsemblMetazoaiF31D4.7; F31D4.7; WBGene00006687
GeneIDi185149
KEGGicel:CELE_F31D4.7
UCSCiF31D4.7 c. elegans

Similar proteinsi

Entry informationi

Entry nameiO45422_CAEEL
AccessioniPrimary (citable) accession number: O45422
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported