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Protein
Submitted name:

FK506-Binding protein family

Gene

fkb-6

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • FK506 binding Source: GO_Central
  • Hsp90 protein binding Source: WormBase
  • peptidyl-prolyl cis-trans isomerase activity Source: WormBase

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • protein peptidyl-prolyl isomerization Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
FK506-Binding protein familyImported
Gene namesi
Name:fkb-6Imported
ORF Names:CELE_F31D4.3Imported, F31D4.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF31D4.3; CE15929; WBGene00001431; fkb-6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiO45418.
PaxDbiO45418.
PRIDEiO45418.

2D gel databases

World-2DPAGE0020:O45418.

Interactioni

GO - Molecular functioni

  • Hsp90 protein binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.F31D4.3.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R9HX-ray1.80A1-135[»]
ProteinModelPortaliO45418.
SMRiO45418. Positions 5-406.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO45418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12189PPIase FKBP-typeInterPro annotationAdd
BLAST
Domaini150 – 23788PPIase FKBP-typeInterPro annotationAdd
BLAST
Domaini261 – 370110TPR_REGIONInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000256916.
InParanoidiO45418.
KOiK09571.
OMAiANSTVYY.
OrthoDBiEOG725DHH.
PhylomeDBiO45418.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O45418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEKIDITP KKDGGVLKLI KKEGQGVVKP TTGTTVKVHY VGTLENGTKF
60 70 80 90 100
DSSRDRGDQF SFNLGRGNVI KGWDLGVATM TKGEVAEFTI RSDYGYGDAG
110 120 130 140 150
SPPKIPGGAT LIFEVELFEW SAEDISPDRD GTILRTIIVE GSKNSFPNDT
160 170 180 190 200
SKVLAHCVGT YQGTEFYNRE VNFHIGEGSE EGLPEGVERA LRRFQLGEKS
210 220 230 240 250
KIEIRGHKYT YGNSPPAGSN IPVNATLEFT IFLKEFEKVP ATWEMTAEEK
260 270 280 290 300
LDAAKQAKDR GTMYLQKGNL KLAYNKYKRA EEVLEYEKST DPEKMAERET
310 320 330 340 350
ILNGAYLNLS LVCSKQNEQL ECIKWCDKVL ETKPGNVKAL YRKATALLTM
360 370 380 390 400
NEVRDAMKLF EKIVEVEPEN KAAAQQIIVC RNTIREQNER DKKRFKNLFA
410 420 430
KISTEEDKPT NTVEDEDEIV ASTSGSSTSN A
Length:431
Mass (Da):48,059
Last modified:June 1, 1998 - v1
Checksum:i54CD4A1A616A95F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07371.1.
PIRiT21594.
RefSeqiNP_508026.1. NM_075625.5.
UniGeneiCel.6935.

Genome annotation databases

EnsemblMetazoaiF31D4.3; F31D4.3; WBGene00001431.
GeneIDi180371.
KEGGicel:CELE_F31D4.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB07371.1.
PIRiT21594.
RefSeqiNP_508026.1. NM_075625.5.
UniGeneiCel.6935.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R9HX-ray1.80A1-135[»]
ProteinModelPortaliO45418.
SMRiO45418. Positions 5-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F31D4.3.

2D gel databases

World-2DPAGE0020:O45418.

Proteomic databases

EPDiO45418.
PaxDbiO45418.
PRIDEiO45418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF31D4.3; F31D4.3; WBGene00001431.
GeneIDi180371.
KEGGicel:CELE_F31D4.3.

Organism-specific databases

CTDi180371.
WormBaseiF31D4.3; CE15929; WBGene00001431; fkb-6.

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000256916.
InParanoidiO45418.
KOiK09571.
OMAiANSTVYY.
OrthoDBiEOG725DHH.
PhylomeDBiO45418.

Miscellaneous databases

EvolutionaryTraceiO45418.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00254. FKBP_C. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO45418_CAEEL
AccessioniPrimary (citable) accession number: O45418
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.