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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene

tps-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 2
UDP-glucose-glucosephosphate glucosyltransferase 2
Gene namesi
Name:tps-2
Synonyms:tps2
ORF Names:F19H8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF19H8.1a; CE37507; WBGene00006603; tps-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003851771 – 1229Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2Add BLAST1229

Proteomic databases

EPDiO45380.
PaxDbiO45380.
PeptideAtlasiO45380.
PRIDEiO45380.

Expressioni

Developmental stagei

Expressed in all development stages.1 Publication

Gene expression databases

BgeeiWBGene00006603.
ExpressionAtlasiO45380. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.F19H8.1.

Structurei

3D structure databases

ProteinModelPortaliO45380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG1050. Eukaryota.
COG0380. LUCA.
GeneTreeiENSGT00550000075394.
HOGENOMiHOG000016516.
InParanoidiO45380.
OMAiAGSEIQF.
OrthoDBiEOG091G00R4.

Family and domain databases

CDDicd03788. GT1_TPS. 1 hit.
Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequencei

Sequence statusi: Complete.

O45380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEPPPSEK KVREPFSRAM KDVQISDEQR LKELWHLLDL LEIEYKKTAD
60 70 80 90 100
LHTLISSVSE SLTMVWKRRD PKSELALKGL LLILEYCLSH VFDGHAVFEI
110 120 130 140 150
FVSSLGFNTV IFWKHCAGYI FDSDLGRGTK FRDALLFSLT LYDVNTGKNR
160 170 180 190 200
LRELYAAVPG IRKSLLGVNA KQFGERYHHL QKRLARYGSH TSLCSVSSDS
210 220 230 240 250
EGEEAIHNVR SGTHTESESE EDPKAPRSGL ATSHFQQRVI NVSNAPPVSL
260 270 280 290 300
KREKTGDWEI KQGSGGLVAC VDPVMSKDHE NLWLANLGMN INDKKQKRPG
310 320 330 340 350
SVASIPESFP STNTLGLPLI KQTIAEVFFH VLADDDMDAP KNEKQKKARE
360 370 380 390 400
EMSLLGVLNN YNRGNYKLNP VVVQEDDYNV YYGGISNGLL WPALHNLPEY
410 420 430 440 450
IVSEYDDEKI LRAHWCAYVR VNYQFAIDAV RNSRPQDFIW IHDYHLMLVG
460 470 480 490 500
MIMQSLDQHL EVGFFLHIPF QPPGEFFSKY STVGFAVLRG LLRFTKVGFQ
510 520 530 540 550
THRDRTKYIE LVQHYFGTAK IVYDNKMDIY SITNEGWTCS LGVFPVSIKN
560 570 580 590 600
DDFLKFVDLP ETIKLKNDLR KRVMGDTPAP DGRFFFSVER FDYTKGIMEK
610 620 630 640 650
LQAYKRYFER HPDRIGKDVL FQIAVTNRRS VDTYRVYQDE CIDLADKINE
660 670 680 690 700
IFKDPNNPTW KPLVFQTDGL PRSELVAAYL AMDIGVVTPK KDGMNLVAKE
710 720 730 740 750
MLVCNPKAGL VLSTGAGSEI QFTTAGLYSD KEKNYHRISN VFDPDSYCDA
760 770 780 790 800
FYSAALEPED VRAEHGKRLH EFIMANDIER WSCAFLDPSW THEVIRPTQV
810 820 830 840 850
ETLDDFFSLM MKTRNVRRQI VGRVLKGIPI RSHFAISLRN AKESLEQICK
860 870 880 890 900
PGTHTAEFKS GPDSKEVAHF EIDNELQEFE RDLSFIDYVQ SDDADNVEQF
910 920 930 940 950
VDTLISSHPI SVETYKKEVE NAVELLYSAD HFHYFFTDRD GTLKSYSCSY
960 970 980 990 1000
PSSIQPAYSG VIQAQFARRC AQTCVILTTA PLMHIGVLDV STIPNGYYYF
1010 1020 1030 1040 1050
GASGGREWFI DNGHNFKDES ILKGEKADVL ASAYTRISHL LEEPEFRPFT
1060 1070 1080 1090 1100
WVGSGLQKHY GHLTIAFQDV YKTITEAQGK QLHEEIEKIV KDVDPHGTRL
1110 1120 1130 1140 1150
QLASTEFDIK VYMKTETDGH VFDKGDGLRL LCEKMHCDLT EGNVLVCGDS
1160 1170 1180 1190 1200
STDIPMLKEC LIRNPKGVYT IWVTVNDKLK EEVRALCASY SNSNVAFVSC
1210 1220
PEVLLGAMAQ ATIREITITR TRKMSRNIV
Length:1,229
Mass (Da):139,911
Last modified:November 23, 2004 - v3
Checksum:i707A48DA05E6383D
GO

Sequence cautioni

The sequence CAD54507 differs from that shown. Reason: Frameshift at positions 928, 930 and 936.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512333 mRNA. Translation: CAD54507.2. Frameshift.
AJ811574 mRNA. Translation: CAH18872.1.
Z93378 Genomic DNA. Translation: CAB07584.3.
PIRiT21127.
RefSeqiNP_497035.3. NM_064634.5.
UniGeneiCel.34195.

Genome annotation databases

EnsemblMetazoaiF19H8.1a; F19H8.1a; WBGene00006603.
GeneIDi3565050.
KEGGicel:CELE_F19H8.1.
UCSCiF19H8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512333 mRNA. Translation: CAD54507.2. Frameshift.
AJ811574 mRNA. Translation: CAH18872.1.
Z93378 Genomic DNA. Translation: CAB07584.3.
PIRiT21127.
RefSeqiNP_497035.3. NM_064634.5.
UniGeneiCel.34195.

3D structure databases

ProteinModelPortaliO45380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F19H8.1.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Proteomic databases

EPDiO45380.
PaxDbiO45380.
PeptideAtlasiO45380.
PRIDEiO45380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF19H8.1a; F19H8.1a; WBGene00006603.
GeneIDi3565050.
KEGGicel:CELE_F19H8.1.
UCSCiF19H8.1. c. elegans.

Organism-specific databases

CTDi3565050.
WormBaseiF19H8.1a; CE37507; WBGene00006603; tps-2.

Phylogenomic databases

eggNOGiKOG1050. Eukaryota.
COG0380. LUCA.
GeneTreeiENSGT00550000075394.
HOGENOMiHOG000016516.
InParanoidiO45380.
OMAiAGSEIQF.
OrthoDBiEOG091G00R4.

Miscellaneous databases

PROiO45380.

Gene expression databases

BgeeiWBGene00006603.
ExpressionAtlasiO45380. differential.

Family and domain databases

CDDicd03788. GT1_TPS. 1 hit.
Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPS2_CAEEL
AccessioniPrimary (citable) accession number: O45380
Secondary accession number(s): Q7YZT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.