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O45380

- TPS2_CAEEL

UniProt

O45380 - TPS2_CAEEL

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene
tps-2, tps2, F19H8.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 2
UDP-glucose-glucosephosphate glucosyltransferase 2
Gene namesi
Name:tps-2
Synonyms:tps2
ORF Names:F19H8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF19H8.1a; CE37507; WBGene00006603; tps-2.

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12291229Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2PRO_0000385177Add
BLAST

Proteomic databases

PaxDbiO45380.
PRIDEiO45380.

Expressioni

Developmental stagei

Expressed in all development stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.F19H8.1.

Structurei

3D structure databases

ProteinModelPortaliO45380.
SMRiO45380. Positions 358-786.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Phylogenomic databases

eggNOGiCOG0380.
GeneTreeiENSGT00550000075394.
HOGENOMiHOG000016516.
InParanoidiO45380.
OMAiAGSEIQF.
OrthoDBiEOG7P2XRB.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequencei

Sequence statusi: Complete.

O45380-1 [UniParc]FASTAAdd to Basket

« Hide

MGSEPPPSEK KVREPFSRAM KDVQISDEQR LKELWHLLDL LEIEYKKTAD     50
LHTLISSVSE SLTMVWKRRD PKSELALKGL LLILEYCLSH VFDGHAVFEI 100
FVSSLGFNTV IFWKHCAGYI FDSDLGRGTK FRDALLFSLT LYDVNTGKNR 150
LRELYAAVPG IRKSLLGVNA KQFGERYHHL QKRLARYGSH TSLCSVSSDS 200
EGEEAIHNVR SGTHTESESE EDPKAPRSGL ATSHFQQRVI NVSNAPPVSL 250
KREKTGDWEI KQGSGGLVAC VDPVMSKDHE NLWLANLGMN INDKKQKRPG 300
SVASIPESFP STNTLGLPLI KQTIAEVFFH VLADDDMDAP KNEKQKKARE 350
EMSLLGVLNN YNRGNYKLNP VVVQEDDYNV YYGGISNGLL WPALHNLPEY 400
IVSEYDDEKI LRAHWCAYVR VNYQFAIDAV RNSRPQDFIW IHDYHLMLVG 450
MIMQSLDQHL EVGFFLHIPF QPPGEFFSKY STVGFAVLRG LLRFTKVGFQ 500
THRDRTKYIE LVQHYFGTAK IVYDNKMDIY SITNEGWTCS LGVFPVSIKN 550
DDFLKFVDLP ETIKLKNDLR KRVMGDTPAP DGRFFFSVER FDYTKGIMEK 600
LQAYKRYFER HPDRIGKDVL FQIAVTNRRS VDTYRVYQDE CIDLADKINE 650
IFKDPNNPTW KPLVFQTDGL PRSELVAAYL AMDIGVVTPK KDGMNLVAKE 700
MLVCNPKAGL VLSTGAGSEI QFTTAGLYSD KEKNYHRISN VFDPDSYCDA 750
FYSAALEPED VRAEHGKRLH EFIMANDIER WSCAFLDPSW THEVIRPTQV 800
ETLDDFFSLM MKTRNVRRQI VGRVLKGIPI RSHFAISLRN AKESLEQICK 850
PGTHTAEFKS GPDSKEVAHF EIDNELQEFE RDLSFIDYVQ SDDADNVEQF 900
VDTLISSHPI SVETYKKEVE NAVELLYSAD HFHYFFTDRD GTLKSYSCSY 950
PSSIQPAYSG VIQAQFARRC AQTCVILTTA PLMHIGVLDV STIPNGYYYF 1000
GASGGREWFI DNGHNFKDES ILKGEKADVL ASAYTRISHL LEEPEFRPFT 1050
WVGSGLQKHY GHLTIAFQDV YKTITEAQGK QLHEEIEKIV KDVDPHGTRL 1100
QLASTEFDIK VYMKTETDGH VFDKGDGLRL LCEKMHCDLT EGNVLVCGDS 1150
STDIPMLKEC LIRNPKGVYT IWVTVNDKLK EEVRALCASY SNSNVAFVSC 1200
PEVLLGAMAQ ATIREITITR TRKMSRNIV 1229
Length:1,229
Mass (Da):139,911
Last modified:November 23, 2004 - v3
Checksum:i707A48DA05E6383D
GO

Sequence cautioni

The sequence CAD54507.2 differs from that shown. Reason: Frameshift at positions 928, 930 and 936.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ512333 mRNA. Translation: CAD54507.2. Frameshift.
AJ811574 mRNA. Translation: CAH18872.1.
Z93378 Genomic DNA. Translation: CAB07584.3.
PIRiT21127.
RefSeqiNP_497035.3. NM_064634.5.
UniGeneiCel.34195.

Genome annotation databases

EnsemblMetazoaiF19H8.1a; F19H8.1a; WBGene00006603.
GeneIDi3565050.
KEGGicel:CELE_F19H8.1.
UCSCiF19H8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ512333 mRNA. Translation: CAD54507.2 . Frameshift.
AJ811574 mRNA. Translation: CAH18872.1 .
Z93378 Genomic DNA. Translation: CAB07584.3 .
PIRi T21127.
RefSeqi NP_497035.3. NM_064634.5.
UniGenei Cel.34195.

3D structure databases

ProteinModelPortali O45380.
SMRi O45380. Positions 358-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F19H8.1.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbi O45380.
PRIDEi O45380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F19H8.1a ; F19H8.1a ; WBGene00006603 .
GeneIDi 3565050.
KEGGi cel:CELE_F19H8.1.
UCSCi F19H8.1. c. elegans.

Organism-specific databases

CTDi 3565050.
WormBasei F19H8.1a ; CE37507 ; WBGene00006603 ; tps-2.

Phylogenomic databases

eggNOGi COG0380.
GeneTreei ENSGT00550000075394.
HOGENOMi HOG000016516.
InParanoidi O45380.
OMAi AGSEIQF.
OrthoDBi EOG7P2XRB.

Miscellaneous databases

NextBioi 954989.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
    Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
    Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: Bristol N2.
  2. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
    Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
    Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTPS2_CAEEL
AccessioniPrimary (citable) accession number: O45380
Secondary accession number(s): Q7YZT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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