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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene

tps-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.

Catalytic activityi

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 2
UDP-glucose-glucosephosphate glucosyltransferase 2
Gene namesi
Name:tps-2
Synonyms:tps2
ORF Names:F19H8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF19H8.1a ; CE37507 ; WBGene00006603 ; tps-2

Subcellular locationi

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003851771 – 1229Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2Add BLAST1229

Proteomic databases

EPDiO45380
PaxDbiO45380
PeptideAtlasiO45380
PRIDEiO45380

Expressioni

Developmental stagei

Expressed in all development stages.1 Publication

Gene expression databases

BgeeiWBGene00006603
ExpressionAtlasiO45380 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.F19H8.1

Structurei

3D structure databases

ProteinModelPortaliO45380
SMRiO45380
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG1050 Eukaryota
COG0380 LUCA
GeneTreeiENSGT00550000075394
HOGENOMiHOG000016516
InParanoidiO45380
OMAiYQDECID
OrthoDBiEOG091G00R4

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit

Sequencei

Sequence statusi: Complete.

O45380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEPPPSEK KVREPFSRAM KDVQISDEQR LKELWHLLDL LEIEYKKTAD
60 70 80 90 100
LHTLISSVSE SLTMVWKRRD PKSELALKGL LLILEYCLSH VFDGHAVFEI
110 120 130 140 150
FVSSLGFNTV IFWKHCAGYI FDSDLGRGTK FRDALLFSLT LYDVNTGKNR
160 170 180 190 200
LRELYAAVPG IRKSLLGVNA KQFGERYHHL QKRLARYGSH TSLCSVSSDS
210 220 230 240 250
EGEEAIHNVR SGTHTESESE EDPKAPRSGL ATSHFQQRVI NVSNAPPVSL
260 270 280 290 300
KREKTGDWEI KQGSGGLVAC VDPVMSKDHE NLWLANLGMN INDKKQKRPG
310 320 330 340 350
SVASIPESFP STNTLGLPLI KQTIAEVFFH VLADDDMDAP KNEKQKKARE
360 370 380 390 400
EMSLLGVLNN YNRGNYKLNP VVVQEDDYNV YYGGISNGLL WPALHNLPEY
410 420 430 440 450
IVSEYDDEKI LRAHWCAYVR VNYQFAIDAV RNSRPQDFIW IHDYHLMLVG
460 470 480 490 500
MIMQSLDQHL EVGFFLHIPF QPPGEFFSKY STVGFAVLRG LLRFTKVGFQ
510 520 530 540 550
THRDRTKYIE LVQHYFGTAK IVYDNKMDIY SITNEGWTCS LGVFPVSIKN
560 570 580 590 600
DDFLKFVDLP ETIKLKNDLR KRVMGDTPAP DGRFFFSVER FDYTKGIMEK
610 620 630 640 650
LQAYKRYFER HPDRIGKDVL FQIAVTNRRS VDTYRVYQDE CIDLADKINE
660 670 680 690 700
IFKDPNNPTW KPLVFQTDGL PRSELVAAYL AMDIGVVTPK KDGMNLVAKE
710 720 730 740 750
MLVCNPKAGL VLSTGAGSEI QFTTAGLYSD KEKNYHRISN VFDPDSYCDA
760 770 780 790 800
FYSAALEPED VRAEHGKRLH EFIMANDIER WSCAFLDPSW THEVIRPTQV
810 820 830 840 850
ETLDDFFSLM MKTRNVRRQI VGRVLKGIPI RSHFAISLRN AKESLEQICK
860 870 880 890 900
PGTHTAEFKS GPDSKEVAHF EIDNELQEFE RDLSFIDYVQ SDDADNVEQF
910 920 930 940 950
VDTLISSHPI SVETYKKEVE NAVELLYSAD HFHYFFTDRD GTLKSYSCSY
960 970 980 990 1000
PSSIQPAYSG VIQAQFARRC AQTCVILTTA PLMHIGVLDV STIPNGYYYF
1010 1020 1030 1040 1050
GASGGREWFI DNGHNFKDES ILKGEKADVL ASAYTRISHL LEEPEFRPFT
1060 1070 1080 1090 1100
WVGSGLQKHY GHLTIAFQDV YKTITEAQGK QLHEEIEKIV KDVDPHGTRL
1110 1120 1130 1140 1150
QLASTEFDIK VYMKTETDGH VFDKGDGLRL LCEKMHCDLT EGNVLVCGDS
1160 1170 1180 1190 1200
STDIPMLKEC LIRNPKGVYT IWVTVNDKLK EEVRALCASY SNSNVAFVSC
1210 1220
PEVLLGAMAQ ATIREITITR TRKMSRNIV
Length:1,229
Mass (Da):139,911
Last modified:November 23, 2004 - v3
Checksum:i707A48DA05E6383D
GO

Sequence cautioni

The sequence CAD54507 differs from that shown. Reason: Frameshift at positions 928, 930 and 936.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512333 mRNA Translation: CAD54507.2 Frameshift.
AJ811574 mRNA Translation: CAH18872.1
Z93378 Genomic DNA Translation: CAB07584.3
PIRiT21127
RefSeqiNP_497035.3, NM_064634.5
UniGeneiCel.34195

Genome annotation databases

EnsemblMetazoaiF19H8.1a; F19H8.1a; WBGene00006603
GeneIDi3565050
KEGGicel:CELE_F19H8.1
UCSCiF19H8.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTPS2_CAEEL
AccessioniPrimary (citable) accession number: O45380
Secondary accession number(s): Q7YZT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health