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O45380

- TPS2_CAEEL

UniProt

O45380 - TPS2_CAEEL

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

Gene

tps-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 (EC:2.4.1.15)
    Alternative name(s):
    Trehalose-6-phosphate synthase 2
    UDP-glucose-glucosephosphate glucosyltransferase 2
    Gene namesi
    Name:tps-2
    Synonyms:tps2
    ORF Names:F19H8.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF19H8.1a; CE37507; WBGene00006603; tps-2.

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12291229Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2PRO_0000385177Add
    BLAST

    Proteomic databases

    PaxDbiO45380.
    PRIDEiO45380.

    Expressioni

    Developmental stagei

    Expressed in all development stages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F19H8.1.

    Structurei

    3D structure databases

    ProteinModelPortaliO45380.
    SMRiO45380. Positions 358-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
    In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    GeneTreeiENSGT00550000075394.
    HOGENOMiHOG000016516.
    InParanoidiO45380.
    OMAiAGSEIQF.
    OrthoDBiEOG7P2XRB.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O45380-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSEPPPSEK KVREPFSRAM KDVQISDEQR LKELWHLLDL LEIEYKKTAD     50
    LHTLISSVSE SLTMVWKRRD PKSELALKGL LLILEYCLSH VFDGHAVFEI 100
    FVSSLGFNTV IFWKHCAGYI FDSDLGRGTK FRDALLFSLT LYDVNTGKNR 150
    LRELYAAVPG IRKSLLGVNA KQFGERYHHL QKRLARYGSH TSLCSVSSDS 200
    EGEEAIHNVR SGTHTESESE EDPKAPRSGL ATSHFQQRVI NVSNAPPVSL 250
    KREKTGDWEI KQGSGGLVAC VDPVMSKDHE NLWLANLGMN INDKKQKRPG 300
    SVASIPESFP STNTLGLPLI KQTIAEVFFH VLADDDMDAP KNEKQKKARE 350
    EMSLLGVLNN YNRGNYKLNP VVVQEDDYNV YYGGISNGLL WPALHNLPEY 400
    IVSEYDDEKI LRAHWCAYVR VNYQFAIDAV RNSRPQDFIW IHDYHLMLVG 450
    MIMQSLDQHL EVGFFLHIPF QPPGEFFSKY STVGFAVLRG LLRFTKVGFQ 500
    THRDRTKYIE LVQHYFGTAK IVYDNKMDIY SITNEGWTCS LGVFPVSIKN 550
    DDFLKFVDLP ETIKLKNDLR KRVMGDTPAP DGRFFFSVER FDYTKGIMEK 600
    LQAYKRYFER HPDRIGKDVL FQIAVTNRRS VDTYRVYQDE CIDLADKINE 650
    IFKDPNNPTW KPLVFQTDGL PRSELVAAYL AMDIGVVTPK KDGMNLVAKE 700
    MLVCNPKAGL VLSTGAGSEI QFTTAGLYSD KEKNYHRISN VFDPDSYCDA 750
    FYSAALEPED VRAEHGKRLH EFIMANDIER WSCAFLDPSW THEVIRPTQV 800
    ETLDDFFSLM MKTRNVRRQI VGRVLKGIPI RSHFAISLRN AKESLEQICK 850
    PGTHTAEFKS GPDSKEVAHF EIDNELQEFE RDLSFIDYVQ SDDADNVEQF 900
    VDTLISSHPI SVETYKKEVE NAVELLYSAD HFHYFFTDRD GTLKSYSCSY 950
    PSSIQPAYSG VIQAQFARRC AQTCVILTTA PLMHIGVLDV STIPNGYYYF 1000
    GASGGREWFI DNGHNFKDES ILKGEKADVL ASAYTRISHL LEEPEFRPFT 1050
    WVGSGLQKHY GHLTIAFQDV YKTITEAQGK QLHEEIEKIV KDVDPHGTRL 1100
    QLASTEFDIK VYMKTETDGH VFDKGDGLRL LCEKMHCDLT EGNVLVCGDS 1150
    STDIPMLKEC LIRNPKGVYT IWVTVNDKLK EEVRALCASY SNSNVAFVSC 1200
    PEVLLGAMAQ ATIREITITR TRKMSRNIV 1229
    Length:1,229
    Mass (Da):139,911
    Last modified:November 23, 2004 - v3
    Checksum:i707A48DA05E6383D
    GO

    Sequence cautioni

    The sequence CAD54507.2 differs from that shown. Reason: Frameshift at positions 928, 930 and 936.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ512333 mRNA. Translation: CAD54507.2. Frameshift.
    AJ811574 mRNA. Translation: CAH18872.1.
    Z93378 Genomic DNA. Translation: CAB07584.3.
    PIRiT21127.
    RefSeqiNP_497035.3. NM_064634.5.
    UniGeneiCel.34195.

    Genome annotation databases

    EnsemblMetazoaiF19H8.1a; F19H8.1a; WBGene00006603.
    GeneIDi3565050.
    KEGGicel:CELE_F19H8.1.
    UCSCiF19H8.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ512333 mRNA. Translation: CAD54507.2 . Frameshift.
    AJ811574 mRNA. Translation: CAH18872.1 .
    Z93378 Genomic DNA. Translation: CAB07584.3 .
    PIRi T21127.
    RefSeqi NP_497035.3. NM_064634.5.
    UniGenei Cel.34195.

    3D structure databases

    ProteinModelPortali O45380.
    SMRi O45380. Positions 358-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F19H8.1.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Proteomic databases

    PaxDbi O45380.
    PRIDEi O45380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F19H8.1a ; F19H8.1a ; WBGene00006603 .
    GeneIDi 3565050.
    KEGGi cel:CELE_F19H8.1.
    UCSCi F19H8.1. c. elegans.

    Organism-specific databases

    CTDi 3565050.
    WormBasei F19H8.1a ; CE37507 ; WBGene00006603 ; tps-2.

    Phylogenomic databases

    eggNOGi COG0380.
    GeneTreei ENSGT00550000075394.
    HOGENOMi HOG000016516.
    InParanoidi O45380.
    OMAi AGSEIQF.
    OrthoDBi EOG7P2XRB.

    Miscellaneous databases

    NextBioi 954989.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR001830. Glyco_trans_20.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
      Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
      Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
      Strain: Bristol N2.
    2. "Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
      Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
      Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiTPS2_CAEEL
    AccessioniPrimary (citable) accession number: O45380
    Secondary accession number(s): Q7YZT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3