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O45380 (TPS2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2

EC=2.4.1.15
Alternative name(s):
Trehalose-6-phosphate synthase 2
UDP-glucose-glucosephosphate glucosyltransferase 2
Gene names
Name:tps-2
Synonyms:tps2
ORF Names:F19H8.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1229 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a 2 step process.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Developmental stage

Expressed in all development stages. Ref.1

Disruption phenotype

No visible phenotype. Ref.1

Sequence similarities

In the N-terminal section; belongs to the glycosyltransferase 20 family.

In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.

Sequence caution

The sequence CAD54507.2 differs from that shown. Reason: Frameshift at positions 928, 930 and 936.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12291229Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2
PRO_0000385177

Sequences

Sequence LengthMass (Da)Tools
O45380 [UniParc].

Last modified November 23, 2004. Version 3.
Checksum: 707A48DA05E6383D

FASTA1,229139,911
        10         20         30         40         50         60 
MGSEPPPSEK KVREPFSRAM KDVQISDEQR LKELWHLLDL LEIEYKKTAD LHTLISSVSE 

        70         80         90        100        110        120 
SLTMVWKRRD PKSELALKGL LLILEYCLSH VFDGHAVFEI FVSSLGFNTV IFWKHCAGYI 

       130        140        150        160        170        180 
FDSDLGRGTK FRDALLFSLT LYDVNTGKNR LRELYAAVPG IRKSLLGVNA KQFGERYHHL 

       190        200        210        220        230        240 
QKRLARYGSH TSLCSVSSDS EGEEAIHNVR SGTHTESESE EDPKAPRSGL ATSHFQQRVI 

       250        260        270        280        290        300 
NVSNAPPVSL KREKTGDWEI KQGSGGLVAC VDPVMSKDHE NLWLANLGMN INDKKQKRPG 

       310        320        330        340        350        360 
SVASIPESFP STNTLGLPLI KQTIAEVFFH VLADDDMDAP KNEKQKKARE EMSLLGVLNN 

       370        380        390        400        410        420 
YNRGNYKLNP VVVQEDDYNV YYGGISNGLL WPALHNLPEY IVSEYDDEKI LRAHWCAYVR 

       430        440        450        460        470        480 
VNYQFAIDAV RNSRPQDFIW IHDYHLMLVG MIMQSLDQHL EVGFFLHIPF QPPGEFFSKY 

       490        500        510        520        530        540 
STVGFAVLRG LLRFTKVGFQ THRDRTKYIE LVQHYFGTAK IVYDNKMDIY SITNEGWTCS 

       550        560        570        580        590        600 
LGVFPVSIKN DDFLKFVDLP ETIKLKNDLR KRVMGDTPAP DGRFFFSVER FDYTKGIMEK 

       610        620        630        640        650        660 
LQAYKRYFER HPDRIGKDVL FQIAVTNRRS VDTYRVYQDE CIDLADKINE IFKDPNNPTW 

       670        680        690        700        710        720 
KPLVFQTDGL PRSELVAAYL AMDIGVVTPK KDGMNLVAKE MLVCNPKAGL VLSTGAGSEI 

       730        740        750        760        770        780 
QFTTAGLYSD KEKNYHRISN VFDPDSYCDA FYSAALEPED VRAEHGKRLH EFIMANDIER 

       790        800        810        820        830        840 
WSCAFLDPSW THEVIRPTQV ETLDDFFSLM MKTRNVRRQI VGRVLKGIPI RSHFAISLRN 

       850        860        870        880        890        900 
AKESLEQICK PGTHTAEFKS GPDSKEVAHF EIDNELQEFE RDLSFIDYVQ SDDADNVEQF 

       910        920        930        940        950        960 
VDTLISSHPI SVETYKKEVE NAVELLYSAD HFHYFFTDRD GTLKSYSCSY PSSIQPAYSG 

       970        980        990       1000       1010       1020 
VIQAQFARRC AQTCVILTTA PLMHIGVLDV STIPNGYYYF GASGGREWFI DNGHNFKDES 

      1030       1040       1050       1060       1070       1080 
ILKGEKADVL ASAYTRISHL LEEPEFRPFT WVGSGLQKHY GHLTIAFQDV YKTITEAQGK 

      1090       1100       1110       1120       1130       1140 
QLHEEIEKIV KDVDPHGTRL QLASTEFDIK VYMKTETDGH VFDKGDGLRL LCEKMHCDLT 

      1150       1160       1170       1180       1190       1200 
EGNVLVCGDS STDIPMLKEC LIRNPKGVYT IWVTVNDKLK EEVRALCASY SNSNVAFVSC 

      1210       1220 
PEVLLGAMAQ ATIREITITR TRKMSRNIV 

« Hide

References

« Hide 'large scale' references
[1]"Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes."
Pellerone F.I., Archer S.K., Behm C.A., Grant W.N., Lacey M.J., Somerville A.C.
Int. J. Parasitol. 33:1195-1206(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
Strain: Bristol N2.
[2]"Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins."
Goyal K., Browne J.A., Burnell A.M., Tunnacliffe A.
Biochimie 87:565-574(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ512333 mRNA. Translation: CAD54507.2. Frameshift.
AJ811574 mRNA. Translation: CAH18872.1.
Z93378 Genomic DNA. Translation: CAB07584.3.
PIRT21127.
RefSeqNP_497035.3. NM_064634.5.
UniGeneCel.34195.

3D structure databases

ProteinModelPortalO45380.
SMRO45380. Positions 358-786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F19H8.1.

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Proteomic databases

PaxDbO45380.
PRIDEO45380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF19H8.1a; F19H8.1a; WBGene00006603.
GeneID3565050.
KEGGcel:CELE_F19H8.1.
UCSCF19H8.1. c. elegans.

Organism-specific databases

CTD3565050.
WormBaseF19H8.1a; CE37507; WBGene00006603; tps-2.

Phylogenomic databases

eggNOGCOG0380.
GeneTreeENSGT00550000075394.
HOGENOMHOG000016516.
InParanoidO45380.
OMAAGSEIQF.
OrthoDBEOG7P2XRB.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
ProtoNetSearch...

Other

NextBio954989.

Entry information

Entry nameTPS2_CAEEL
AccessionPrimary (citable) accession number: O45380
Secondary accession number(s): Q7YZT5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase