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Protein

ADP-ribosylation factor-like protein 3

Gene

arl-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi68 – 725GTPBy similarity
Nucleotide bindingi127 – 1304GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5624138. Trafficking of myristoylated proteins to the cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 3
Gene namesi
Name:arl-3
ORF Names:F19H8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF19H8.3; CE15872; WBGene00000188; arl-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 184183ADP-ribosylation factor-like protein 3PRO_0000207407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiO45379.
PaxDbiO45379.
PRIDEiO45379.

Expressioni

Gene expression databases

BgeeiWBGene00000188.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
pdl-1Q182684EBI-325438,EBI-316181
unc-119Q106585EBI-325438,EBI-325431

Protein-protein interaction databases

BioGridi40402. 1 interaction.
DIPiDIP-24793N.
IntActiO45379. 3 interactions.
MINTiMINT-1046501.
STRINGi6239.F19H8.3.

Structurei

3D structure databases

ProteinModelPortaliO45379.
SMRiO45379. Positions 17-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0074. Eukaryota.
ENOG410Y825. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
InParanoidiO45379.
KOiK07944.
OMAiIQEGMNW.
OrthoDBiEOG091G0O6V.
PhylomeDBiO45379.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLIDVLKSF KSPSGREIRI LLLGLDNAGK TTILKQLSSE DVQHVTPTKG
60 70 80 90 100
FNVKTVAAMG DIRLNVWDIG GQRSIRPYWS NYYENIDTLI FVIDSNDKKR
110 120 130 140 150
FDEMNIELGE LLDEEKLRKV PVLIFANKQD LVTAASSEEI TRKLNLDLLR
160 170 180
DRTWHIQACS ALKNEGINDG ITWVASNLKP ASKK
Length:184
Mass (Da):20,771
Last modified:June 1, 1998 - v1
Checksum:i796818879C2F3004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93378 Genomic DNA. Translation: CAB07583.1.
PIRiT21126.
RefSeqiNP_497037.1. NM_064636.1.
UniGeneiCel.17800.

Genome annotation databases

EnsemblMetazoaiF19H8.3; F19H8.3; WBGene00000188.
GeneIDi175121.
KEGGicel:CELE_F19H8.3.
UCSCiF19H8.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93378 Genomic DNA. Translation: CAB07583.1.
PIRiT21126.
RefSeqiNP_497037.1. NM_064636.1.
UniGeneiCel.17800.

3D structure databases

ProteinModelPortaliO45379.
SMRiO45379. Positions 17-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40402. 1 interaction.
DIPiDIP-24793N.
IntActiO45379. 3 interactions.
MINTiMINT-1046501.
STRINGi6239.F19H8.3.

Proteomic databases

EPDiO45379.
PaxDbiO45379.
PRIDEiO45379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF19H8.3; F19H8.3; WBGene00000188.
GeneIDi175121.
KEGGicel:CELE_F19H8.3.
UCSCiF19H8.3. c. elegans.

Organism-specific databases

CTDi175121.
WormBaseiF19H8.3; CE15872; WBGene00000188; arl-3.

Phylogenomic databases

eggNOGiKOG0074. Eukaryota.
ENOG410Y825. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
InParanoidiO45379.
KOiK07944.
OMAiIQEGMNW.
OrthoDBiEOG091G0O6V.
PhylomeDBiO45379.

Enzyme and pathway databases

ReactomeiR-CEL-5624138. Trafficking of myristoylated proteins to the cilium.

Miscellaneous databases

PROiO45379.

Gene expression databases

BgeeiWBGene00000188.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL3_CAEEL
AccessioniPrimary (citable) accession number: O45379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.