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Protein

ADP-ribosylation factor-like protein 3

Gene

arl-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5624138 Trafficking of myristoylated proteins to the cilium

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 3
Gene namesi
Name:arl-3
ORF Names:F19H8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF19H8.3 ; CE15872 ; WBGene00000188 ; arl-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074072 – 184ADP-ribosylation factor-like protein 3Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiO45379
PaxDbiO45379
PeptideAtlasiO45379
PRIDEiO45379

Expressioni

Gene expression databases

BgeeiWBGene00000188

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi40402, 1 interactor
DIPiDIP-24793N
IntActiO45379, 3 interactors
STRINGi6239.F19H8.3

Structurei

3D structure databases

ProteinModelPortaliO45379
SMRiO45379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0074 Eukaryota
ENOG410Y825 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
InParanoidiO45379
KOiK07944
OMAiASEDITQ
OrthoDBiEOG091G0O6V
PhylomeDBiO45379

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O45379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLIDVLKSF KSPSGREIRI LLLGLDNAGK TTILKQLSSE DVQHVTPTKG
60 70 80 90 100
FNVKTVAAMG DIRLNVWDIG GQRSIRPYWS NYYENIDTLI FVIDSNDKKR
110 120 130 140 150
FDEMNIELGE LLDEEKLRKV PVLIFANKQD LVTAASSEEI TRKLNLDLLR
160 170 180
DRTWHIQACS ALKNEGINDG ITWVASNLKP ASKK
Length:184
Mass (Da):20,771
Last modified:June 1, 1998 - v1
Checksum:i796818879C2F3004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93378 Genomic DNA Translation: CAB07583.1
PIRiT21126
RefSeqiNP_497037.1, NM_064636.1
UniGeneiCel.17800

Genome annotation databases

EnsemblMetazoaiF19H8.3; F19H8.3; WBGene00000188
GeneIDi175121
KEGGicel:CELE_F19H8.3
UCSCiF19H8.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiARL3_CAEEL
AccessioniPrimary (citable) accession number: O45379
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health