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Protein

Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4

Gene

mog-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis.Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi387 – 394ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • developmental growth Source: WormBase
  • embryonic body morphogenesis Source: WormBase
  • feminization of hermaphroditic germ-line Source: WormBase
  • germ cell development Source: WormBase
  • mRNA splicing, via spliceosome Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4 (EC:3.6.4.13)
Alternative name(s):
Masculinization of germline protein 4
Sex determination protein mog-4
Gene namesi
Name:mog-4
ORF Names:C04H5.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC04H5.6a; CE15592; WBGene00003392; mog-4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal. Defects in oocytogenesis and spermatogenesis. Approximately 80% of mutants have an abnormal somatic gonad and no vulva.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551531 – 1008Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4Add BLAST1008

Proteomic databases

EPDiO45244.
PaxDbiO45244.
PeptideAtlasiO45244.
PRIDEiO45244.

Expressioni

Developmental stagei

Expressed throughout development but most strongly in embryos and the L4 larvae stage.2 Publications

Gene expression databases

BgeeiWBGene00003392.
ExpressionAtlasiO45244. baseline and differential.

Interactioni

Subunit structurei

Interacts with mep-1 and smn-1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi40398. 11 interactors.
DIPiDIP-24771N.
IntActiO45244. 3 interactors.
MINTiMINT-1105817.
STRINGi6239.C04H5.6.

Structurei

3D structure databases

ProteinModelPortaliO45244.
SMRiO45244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini374 – 538Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST165
Domaini563 – 737Helicase C-terminalPROSITE-ProRule annotationAdd BLAST175

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi485 – 488DEAH box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00880000137867.
HOGENOMiHOG000175261.
InParanoidiO45244.
KOiK12813.
OMAiVYNQWVE.
OrthoDBiEOG091G030Q.
PhylomeDBiO45244.

Family and domain databases

InterProiView protein in InterPro
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

O45244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEQFINDQ LHSIVGISDR SICQYVHALA KKAKSAPDLV EKLRDAGDFP
60 70 80 90 100
ISPAIQSFAD QLMSRMPRQA TSARQRGPTT AELAEQELNR LNRAVGVLED
110 120 130 140 150
YSASSTKTKN VRKRKESSSE DDEAPIKASK PGKSVKPSKS DDSESDIEAM
160 170 180 190 200
EAKLDADIAE RDALAARINK KEKDKTRNVM EKKRDDNKDK EGSSMDKLRE
210 220 230 240 250
ESRRQYLKKR KVDKLEELEA IVHDDQTLFA REKLTKREKA DMEYRKKVLE
260 270 280 290 300
YTKAHGKAGD VMKMKRYHLP DASTKQIPSQ YVEDDEEDFR PGGDGAKWEE
310 320 330 340 350
EQLMASMLHL GAKDAKRKEQ EFELLLDEKV DFIQALQMPG TNEEVVETEA
360 370 380 390 400
EKKKMSIEET RKSLPVYAFR DAFIEAVKEH QVLIIEGETG SGKTTQLPQY
410 420 430 440 450
LYEAGFCEGG KRIGCTQPRR VAAMSVAARV ADEVGCKLGT QVGYSIRFED
460 470 480 490 500
CTSEKTVLKY MTDGMLLREF LNEPDLASYS VMMIDEAHER TLHTDILFGL
510 520 530 540 550
VKDIARFRKD LKLLISSATL DAEKFSSFFD DAPIFRIPGR RFPVDIYYTQ
560 570 580 590 600
APEADYVDAA IVTIMQIHLT QPLPGDILVF LTGQEEIETV QEALMERSKA
610 620 630 640 650
LGSKIKELIP LPVYANLPSD LQAKIFEPTP KDARKVVLAT NIAETSVTID
660 670 680 690 700
GINYVIDPGF SKQNSFDARS GVEHLHVVTI SKAAANQRAG RAGRTGPGKC
710 720 730 740 750
FRLYTAWAYK HELEEQPIPE IQRTNLGNVV LMLKSLGIHD LVHFDFLDPP
760 770 780 790 800
PQETLVIALE QLYALGALNH RGELTKLGRR MAEFPCDPCM SKMIIASEKY
810 820 830 840 850
ECSEEIVTIA AMLSCNAAVF YRPKAQVIHA DSARKGFWSP AGDHITLMNV
860 870 880 890 900
YNKWQESSFS QRWCVENYVQ HRTMKRARDV RDQLVGLLER VEIETKSSTD
910 920 930 940 950
TIKIRKAITA GYFYNVSKLD NTGHYKTVKH KHTTHPHPNS CLFEETPRWV
960 970 980 990 1000
VYFELVFTSK EFMREMSEIE SGWLLEVAPH YYKGRELEDA TNKKMPKNKG

KSGKDLER
Length:1,008
Mass (Da):114,290
Last modified:December 15, 1998 - v2
Checksum:iF6EB913D919FFD5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286900 mRNA. Translation: AAG01333.1.
Z81462, Z81457 Genomic DNA. Translation: CAB03845.1.
PIRiT18832.
RefSeqiNP_497027.1. NM_064626.4.
UniGeneiCel.17139.

Genome annotation databases

EnsemblMetazoaiC04H5.6a; C04H5.6a; WBGene00003392.
GeneIDi175117.
KEGGicel:CELE_C04H5.6.
UCSCiC04H5.6. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiDHX16_CAEEL
AccessioniPrimary (citable) accession number: O45244
Secondary accession number(s): O45239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: July 5, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families