ID   PROD_CAEEL              Reviewed;         616 AA.
AC   O45228;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Proline dehydrogenase, mitochondrial;
DE            EC=1.5.99.8;
DE   AltName: Full=Proline oxidase;
DE   Flags: Precursor;
GN   ORFNames=B0513.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: L-proline + acceptor = (S)-1-pyrroline-5-
CC       carboxylate + reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
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DR   EMBL; Z82256; CAB05117.2; -; Genomic_DNA.
DR   PIR; T18776; T18776.
DR   RefSeq; NP_502669.2; -.
DR   UniGene; Cel.5441; -.
DR   Ensembl; B0513.5; Caenorhabditis elegans.
DR   GeneID; 178350; -.
DR   KEGG; cel:B0513.5; -.
DR   NMPDR; fig|6239.3.peg.15837; -.
DR   WormBase; WBGene00007197; B0513.5.
DR   WormPep; B0513.5; CE37309.
DR   OMA; O45228; MESCTSA.
DR   BRENDA; 1.5.99.8; 672.
DR   NextBio; 900770; -.
DR   ArrayExpress; O45228; -.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:EC.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR   InterPro; IPR011992; EF-Hand_type.
DR   InterPro; IPR002872; Proline_DH.
DR   InterPro; IPR015659; Proline_oxidase.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   PANTHER; PTHR13914; Proline_oxidase; 1.
DR   Pfam; PF01619; Pro_dh; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase;
KW   Proline metabolism; Transit peptide.
FT   TRANSIT       1      ?       Mitochondrion (Potential).
FT   CHAIN         ?    616       Proline dehydrogenase, mitochondrial.
FT                                /FTId=PRO_0000025802.
SQ   SEQUENCE   616 AA;  69823 MW;  1A3F2B280CDF5D58 CRC64;
     MQAALIGLNF PLQRRFLSGV LTTTSSAKRC YSGDTGKPYD CTSAEHKKEL EECYNRLDLS
     FENTKEAFKS KSNTELVRAL VVLRLCGIQT LVNQNQIILN TMRRVLGKNL FKKTLKNTFF
     GHFVAGETEE EVRHVVEKLR NYGVKSILDY SVEADITSQE ATDKTVKGTS VATVKPAAMT
     PVVDAKTLET TRERYTVHEE FGDRRQGVSS ARTYFYEGEE QCDKNRDIFK DSINAVASAT
     KNEGFVAVKI TALGRPQLLL KLSEAIVQTQ NFFKALTGGM SLQEGRLTSQ EFYKRLGELG
     VKTDTESVKK FFDEVDFDSD GIVDLHGWNH ILDDHVKLGQ LFQVLNIKTG SLEPLIQNLS
     NEEEQEFRNM VRRTLDVAEY AIEKGVRIMV DAEQTYLQPA ISKITIEMMK KYNKGRGNIF
     NTYQAYLKGT LQNMEADMQV ARREGWHFGA KLVRGAYMEQ ERARAKAIGY EDPINDNFEA
     TSKMYESCLT RIADEVHRRG KTNVSVMVAS HNEDTVRFAL NLMKEKCISP SERVMCMAQL
     YGMCDQVSFS LGQAGFSVYK YLPYGPVEEV LPYLSRRALE NGSVLKKANK ERDLLWKELK
     RRISSGEFKA RSSSSS
//